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Q0QER2 (Q0QER2_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108
EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Name:IDH1 EMBL ABD77215.1
OrganismHomo sapiens (Human) EMBL ABD77215.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length371 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding46 – 483NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding281 – 2866NADP By similarity PIRSR PIRSR000108-4
Region65 – 717Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2231Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2461Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site481Substrate By similarity PIRSR PIRSR000108-2
Binding site531NADP By similarity PIRSR PIRSR000108-4
Binding site801Substrate By similarity PIRSR PIRSR000108-2
Binding site1031Substrate By similarity PIRSR PIRSR000108-2
Binding site2311NADP By similarity PIRSR PIRSR000108-4
Binding site2991NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1101Critical for catalysis By similarity PIRSR PIRSR000108-1
Site1831Critical for catalysis By similarity PIRSR PIRSR000108-1

Experimental info

Non-terminal residue11 EMBL ABD77215.1
Non-terminal residue3711 EMBL ABD77215.1

Sequences

Sequence LengthMass (Da)Tools
Q0QER2 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: C78E782D02D297C5

FASTA37141,833
        10         20         30         40         50         60 
LIFPYVELDL HSYDLGIENR DATNDQVTKD AAEAIKKHNV GVKCATITPD EKRVEEFKLK 

        70         80         90        100        110        120 
QMWKSPNGTI RNILGGTVFR EAIICKNIPR LVSGWVKPII IGRHAYGDQY RATDFVVPGP 

       130        140        150        160        170        180 
GKVEITYTPS DGTQKVTYLV HNFEEGGGVA MGMYNQDKSI EDFAHSSFQM ALSKGWPLYL 

       190        200        210        220        230        240 
STKNTILKKY DGRFKDIFQE IYDKQYKSQF EAQKIWYEHR LIDDMVAQAM KSEGGFIWAC 

       250        260        270        280        290        300 
KNYDGDVQSD SVAQGYGSLG MMTSVLVCPD GKTVEAEAAH GTVTRHYRMY QKGQETSTNP 

       310        320        330        340        350        360 
IASIFAWTRG LAHRAKLDNN KELAFFANAL EEVSIETIEA GFMTKDLAAC IKGLPNVQRS 

       370 
DYLNTFEFMD K

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References

[1]"Housekeeping genes for phylogenetic analysis of eutherian relationships."
Kullberg M., Nilsson M.A., Arnason U., Harley E.H., Janke A.
Mol. Biol. Evol. 23:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ403082 mRNA. Translation: ABD77215.1.
IPIIPI00027223.
UniGeneHs.593422.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ0QER2.

Proteomic databases

PRIDEQ0QER2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG006119.

Gene expression databases

ArrayExpressQ0QER2.
BgeeQ0QER2.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIDH1. human.

Entry information

Entry nameQ0QER2_HUMAN
AccessionPrimary (citable) accession number: Q0QER2
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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