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Protein
Submitted name:

Isocitrate dehydrogenase 1

Gene

IDH1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei48SubstrateUniRule annotation1
Binding sitei53NADPUniRule annotation1
Binding sitei80SubstrateUniRule annotation1
Binding sitei103SubstrateUniRule annotation1
Sitei110Critical for catalysisUniRule annotation1
Sitei183Critical for catalysisUniRule annotation1
Metal bindingi223Magnesium or manganeseUniRule annotation1
Binding sitei231NADPUniRule annotation1
Metal bindingi246Magnesium or manganeseUniRule annotation1
Binding sitei299NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 48NADPUniRule annotation3
Nucleotide bindingi281 – 286NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase 1Imported
Gene namesi
Name:IDH1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiQ0QER2.
PeptideAtlasiQ0QER2.
PRIDEiQ0QER2.

Expressioni

Gene expression databases

BgeeiENSG00000138413.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000260985.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 371Iso_dhInterPro annotationAdd BLAST371

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 71Substrate bindingUniRule annotation7

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.
HOVERGENiHBG006119.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q0QER2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LIFPYVELDL HSYDLGIENR DATNDQVTKD AAEAIKKHNV GVKCATITPD
60 70 80 90 100
EKRVEEFKLK QMWKSPNGTI RNILGGTVFR EAIICKNIPR LVSGWVKPII
110 120 130 140 150
IGRHAYGDQY RATDFVVPGP GKVEITYTPS DGTQKVTYLV HNFEEGGGVA
160 170 180 190 200
MGMYNQDKSI EDFAHSSFQM ALSKGWPLYL STKNTILKKY DGRFKDIFQE
210 220 230 240 250
IYDKQYKSQF EAQKIWYEHR LIDDMVAQAM KSEGGFIWAC KNYDGDVQSD
260 270 280 290 300
SVAQGYGSLG MMTSVLVCPD GKTVEAEAAH GTVTRHYRMY QKGQETSTNP
310 320 330 340 350
IASIFAWTRG LAHRAKLDNN KELAFFANAL EEVSIETIEA GFMTKDLAAC
360 370
IKGLPNVQRS DYLNTFEFMD K
Length:371
Mass (Da):41,833
Last modified:September 5, 2006 - v1
Checksum:iC78E782D02D297C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei371Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ403082 mRNA. Translation: ABD77215.1.
UniGeneiHs.593422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ403082 mRNA. Translation: ABD77215.1.
UniGeneiHs.593422.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000260985.

Proteomic databases

PaxDbiQ0QER2.
PeptideAtlasiQ0QER2.
PRIDEiQ0QER2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.
HOVERGENiHBG006119.

Miscellaneous databases

ChiTaRSiIDH1. human.

Gene expression databases

BgeeiENSG00000138413.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ0QER2_HUMAN
AccessioniPrimary (citable) accession number: Q0QER2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.