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Q0QEP3

- Q0QEP3_RAT

UniProt

Q0QEP3 - Q0QEP3_RAT

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Protein

ATP synthase subunit beta

Gene

Atp5b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. proton-transporting ATPase activity, rotational mechanism Source: Ensembl
  3. proton-transporting ATP synthase activity, rotational mechanism Source: InterPro

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. ATP hydrolysis coupled proton transport Source: InterPro
  3. ATP synthesis coupled proton transport Source: InterPro
  4. lipid metabolic process Source: Ensembl
  5. negative regulation of cell adhesion involved in substrate-bound cell migration Source: Ensembl
  6. osteoblast differentiation Source: Ensembl
  7. regulation of intracellular pH Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_216049. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit betaUniRule annotation (EC:3.6.3.14UniRule annotation)
Gene namesi
Name:Atp5bImported
Synonyms:ATP5BImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621368. Atp5b.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. mitochondrial nucleoid Source: Ensembl
  4. mitochondrial proton-transporting ATP synthase complex Source: Ensembl
  5. nucleus Source: Ensembl
  6. plasma membrane Source: Ensembl
  7. proton-transporting ATP synthase complex, catalytic core F(1) Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

CF(1)UniRule annotation

Expressioni

Gene expression databases

ExpressionAtlasiQ0QEP3. baseline.
GenevestigatoriQ0QEP3.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003965.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG004307.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR005722. ATPase_F1-cplx_bsu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01039. atpD. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q0QEP3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
HAEAPEFIEM SVEQEILVTG IKVVDLLAPY AKGGKIGLFG GAGVGKTVLI
60 70 80 90 100
MELINNVAKA HGGYSVFAGV GERTREGNDL YHEMIESGVI NLKDATSKVA
110 120 130 140 150
LVYGQMNEPP GARARVALTG LTVAEYFRDQ EGQDVLLFID NIFRFTQAGS
160 170 180 190 200
EVSALLGRIP SAVGYQPTLA TDMGTMQERI TTTKKGSITS VQAIYVPADD
210 220 230 240 250
LTDPAPATTF AHLDATTVLS RAIAELGIYP AVDPLDSTSR IMDPNIVGSE
260 270 280 290 300
HYDVARGVQK ILQDYKSLQD IIAILGMDEL SEEDKLTVSR ARKIQRFLSQ
310 320 330 340
PFQVAEVFTG HMGKLVPLKE TIKGFQQILA GDYDHLPEQA FYM
Length:343
Mass (Da):37,252
Last modified:September 5, 2006 - v1
Checksum:i9E27C3A20F0859D4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei343 – 3431Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ403101 mRNA. Translation: ABD77234.1.
UniGeneiRn.92965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ403101 mRNA. Translation: ABD77234.1 .
UniGenei Rn.92965.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000003965.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 621368. Atp5b.

Phylogenomic databases

HOVERGENi HBG004307.

Enzyme and pathway databases

Reactomei REACT_216049. Transcriptional activation of mitochondrial biogenesis.

Gene expression databases

ExpressionAtlasi Q0QEP3. baseline.
Genevestigatori Q0QEP3.

Family and domain databases

Gene3Di 1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR005722. ATPase_F1-cplx_bsu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF47917. SSF47917. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01039. atpD. 1 hit.
PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Housekeeping genes for phylogenetic analysis of eutherian relationships."
    Kullberg M., Nilsson M.A., Arnason U., Harley E.H., Janke A.
    Mol. Biol. Evol. 23:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.

Entry informationi

Entry nameiQ0QEP3_RAT
AccessioniPrimary (citable) accession number: Q0QEP3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)