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Q0QEP3

- Q0QEP3_RAT

UniProt

Q0QEP3 - Q0QEP3_RAT

Protein

ATP synthase subunit beta

Gene

Atp5b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Produces ATP from ADP in the presence of a proton gradient across the membrane.UniRule annotation

    Catalytic activityi

    ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. proton-transporting ATPase activity, rotational mechanism Source: Ensembl
    3. proton-transporting ATP synthase activity, rotational mechanism Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. ATP hydrolysis coupled proton transport Source: InterPro
    3. ATP synthesis coupled proton transport Source: InterPro
    4. lipid metabolic process Source: Ensembl
    5. negative regulation of cell adhesion involved in substrate-bound cell migration Source: Ensembl
    6. regulation of intracellular pH Source: Ensembl

    Keywords - Biological processi

    ATP synthesis, Hydrogen ion transportUniRule annotation, Ion transport, Transport

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_216049. Transcriptional activation of mitochondrial biogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP synthase subunit betaUniRule annotation (EC:3.6.3.14UniRule annotation)
    Gene namesi
    Name:Atp5bImported
    Synonyms:ATP5BImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi621368. Atp5b.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. mitochondrial nucleoid Source: Ensembl
    3. mitochondrial proton-transporting ATP synthase complex Source: Ensembl
    4. plasma membrane Source: Ensembl
    5. proton-transporting ATP synthase complex, catalytic core F(1) Source: UniProtKB-KW

    Keywords - Cellular componenti

    CF(1)UniRule annotation

    Expressioni

    Gene expression databases

    ArrayExpressiQ0QEP3.
    GenevestigatoriQ0QEP3.

    Interactioni

    Subunit structurei

    F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.UniRule annotation

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000003965.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATPase alpha/beta chains family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG004307.
    InParanoidiQ0QEP3.

    Family and domain databases

    Gene3Di1.10.1140.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR020003. ATPase_a/bsu_AS.
    IPR005722. ATPase_F1-cplx_bsu.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR024034. ATPase_F1_bsu/V1_C.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00006. ATP-synt_ab. 1 hit.
    PF00306. ATP-synt_ab_C. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF47917. SSF47917. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01039. atpD. 1 hit.
    PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q0QEP3-1 [UniParc]FASTAAdd to Basket

    « Hide

    HAEAPEFIEM SVEQEILVTG IKVVDLLAPY AKGGKIGLFG GAGVGKTVLI    50
    MELINNVAKA HGGYSVFAGV GERTREGNDL YHEMIESGVI NLKDATSKVA 100
    LVYGQMNEPP GARARVALTG LTVAEYFRDQ EGQDVLLFID NIFRFTQAGS 150
    EVSALLGRIP SAVGYQPTLA TDMGTMQERI TTTKKGSITS VQAIYVPADD 200
    LTDPAPATTF AHLDATTVLS RAIAELGIYP AVDPLDSTSR IMDPNIVGSE 250
    HYDVARGVQK ILQDYKSLQD IIAILGMDEL SEEDKLTVSR ARKIQRFLSQ 300
    PFQVAEVFTG HMGKLVPLKE TIKGFQQILA GDYDHLPEQA FYM 343
    Length:343
    Mass (Da):37,252
    Last modified:September 5, 2006 - v1
    Checksum:i9E27C3A20F0859D4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei343 – 3431Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ403101 mRNA. Translation: ABD77234.1.
    UniGeneiRn.92965.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ403101 mRNA. Translation: ABD77234.1 .
    UniGenei Rn.92965.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000003965.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 621368. Atp5b.

    Phylogenomic databases

    HOVERGENi HBG004307.
    InParanoidi Q0QEP3.

    Enzyme and pathway databases

    Reactomei REACT_216049. Transcriptional activation of mitochondrial biogenesis.

    Gene expression databases

    ArrayExpressi Q0QEP3.
    Genevestigatori Q0QEP3.

    Family and domain databases

    Gene3Di 1.10.1140.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR020003. ATPase_a/bsu_AS.
    IPR005722. ATPase_F1-cplx_bsu.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR024034. ATPase_F1_bsu/V1_C.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00006. ATP-synt_ab. 1 hit.
    PF00306. ATP-synt_ab_C. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47917. SSF47917. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01039. atpD. 1 hit.
    PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Housekeeping genes for phylogenetic analysis of eutherian relationships."
      Kullberg M., Nilsson M.A., Arnason U., Harley E.H., Janke A.
      Mol. Biol. Evol. 23:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: LiverImported.

    Entry informationi

    Entry nameiQ0QEP3_RAT
    AccessioniPrimary (citable) accession number: Q0QEP3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)