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Protein

ATP synthase subunit beta

Gene

ATP5B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ATP synthesis

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit betaUniRule annotation (EC:3.6.3.14UniRule annotation)
Gene namesi
Name:ATP5BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CF(1)UniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ0QEN7.
PeptideAtlasiQ0QEN7.
PRIDEiQ0QEN7.

Expressioni

Gene expression databases

BgeeiENSG00000110955.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000262030.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 318185AAAInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1350. Eukaryota.
COG0055. LUCA.
HOVERGENiHBG004307.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01347. ATP_synth_beta_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR005722. ATPase_F1-cplx_bsu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01039. atpD. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q0QEN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AVIGAVVDVQ FDEGLPPILN ALEVQGRETR LVLEVAQHLG ESTVRTIAMD
60 70 80 90 100
GTEGLVRGQK VLDSGAPIKI PVGPETLGRI MNVIGEPIDE RGPIKTKQFA
110 120 130 140 150
PIHAEAPEFM EMSVEQEILV TGIKVVDLLA PYAKGGKIGL FGGAGVGKTV
160 170 180 190 200
LIMELINNVA KAHGGYSVFA GVGERTREGN DLYHEMIESG VINLKDATSK
210 220 230 240 250
VALVYGQMNE PPGARARVAL TGLTVAEYFR DQEGQDVLLF IDNIFRFTQA
260 270 280 290 300
GSEVSALLGR IPSAVGYQPT LATDMGTMQE RITTTKKGSI TSVQAIYVPA
310 320 330 340 350
DDLTDPAPAT TFAHLDATTV LSRAIAELGI YPAVDPLDST SRIMDPNIVG
360 370 380 390 400
SEHYDVARGV QKILQDYKSL QDIIAILGMD ELSEEDKLTV SRARKIQRFL
410 420 430 440
SQPFQVAEVF TGHMGKLVPL KETIKGFQQI LAGEYDHLPE QAFYM
Length:445
Mass (Da):48,113
Last modified:October 31, 2006 - v1
Checksum:i3D70087BBCCB2EAB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei445 – 4451Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ403107 mRNA. Translation: ABD77240.1.
UniGeneiHs.406510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ403107 mRNA. Translation: ABD77240.1.
UniGeneiHs.406510.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000262030.

Proteomic databases

PaxDbiQ0QEN7.
PeptideAtlasiQ0QEN7.
PRIDEiQ0QEN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1350. Eukaryota.
COG0055. LUCA.
HOVERGENiHBG004307.

Miscellaneous databases

ChiTaRSiATP5B. human.

Gene expression databases

BgeeiENSG00000110955.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01347. ATP_synth_beta_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR005722. ATPase_F1-cplx_bsu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01039. atpD. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ0QEN7_HUMAN
AccessioniPrimary (citable) accession number: Q0QEN7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2006
Last sequence update: October 31, 2006
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.