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Q0QEE1

- Q0QEE1_9PICO

UniProt

Q0QEE1 - Q0QEE1_9PICO

Protein
Submitted name:

Polyprotein

Gene
N/A
Organism
Foot-and-mouth disease virus - type C
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    NTP + H2O = NDP + phosphate.SAAS annotation
    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation
    Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.SAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1886 – 18861Diphosphate 2
    Binding sitei1961 – 19611Diphosphate 2; via amide nitrogen

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cysteine-type endopeptidase activity Source: InterPro
    3. ion channel activity Source: UniProtKB-KW
    4. RNA binding Source: UniProtKB-KW
    5. RNA-directed RNA polymerase activity Source: UniProtKB-KW
    6. RNA helicase activity Source: InterPro
    7. structural molecule activity Source: InterPro

    GO - Biological processi

    1. pore formation by virus in membrane of host cell Source: UniProtKB-KW
    2. protein oligomerization Source: UniProtKB-KW
    3. transcription, DNA-templated Source: InterPro
    4. viral entry into host cell Source: UniProtKB-KW
    5. viral RNA genome replication Source: InterPro
    6. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    HelicaseSAAS annotation, Hydrolase, Ion channel, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Thiol proteaseSAAS annotation, Transferase, Viral ion channelSAAS annotation

    Keywords - Biological processi

    Host-virus interaction, Ion transport, Transport, Viral attachment to host cellSAAS annotation, Viral RNA replicationSAAS annotation, Virus entry into host cell

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-bindingSAAS annotation

    Protein family/group databases

    MEROPSiC03.008.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    PolyproteinImported
    OrganismiFoot-and-mouth disease virus - type CImported
    Taxonomic identifieri12116 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeAphthovirus

    Subcellular locationi

    Host cytoplasmic vesicle membrane SAAS annotation; Peripheral membrane protein SAAS annotation; Cytoplasmic side SAAS annotation

    GO - Cellular componenti

    1. host cell cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    2. icosahedral viral capsid Source: InterPro
    3. integral to membrane of host cell Source: UniProtKB-KW
    4. membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid proteinSAAS annotation, Host cytoplasmSAAS annotation, Host cytoplasmic vesicleSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6262truncated leader proteaseImportedPRO_5000141359Add
    BLAST
    Chaini63 – 14785VP4 proteinImportedPRO_5000141360Add
    BLAST
    Chaini148 – 365218VP2 proteinImportedPRO_5000141361Add
    BLAST
    Chaini366 – 584219VP3 proteinImportedPRO_5000141362Add
    BLAST
    Chaini585 – 793209VP1 proteinImportedPRO_5000141363Add
    BLAST
    Chaini794 – 809162A proteaseImportedPRO_5000141364Add
    BLAST
    Chaini810 – 9961872B proteinImportedPRO_5000141365Add
    BLAST
    Chaini997 – 12812852C proteinImportedPRO_5000141366Add
    BLAST
    Chaini1282 – 14341533A proteinImportedPRO_5000141367Add
    BLAST
    Chaini1435 – 145723VPg1 proteinImportedPRO_5000141368Add
    BLAST
    Chaini1458 – 148124VPg2 proteinImportedPRO_5000141369Add
    BLAST
    Chaini1482 – 150524VPg3 proteinImportedPRO_5000141370Add
    BLAST
    Chaini1506 – 17182133C proteaseImportedPRO_5000141371Add
    BLAST
    Chaini1719 – 21884703D polymeraseImportedPRO_5000141372Add
    BLAST

    Keywords - PTMi

    PhosphoproteinSAAS annotation

    Structurei

    Miscellaneous databases

    EvolutionaryTraceiQ0QEE1.

    Family & Domainsi

    Sequence similaritiesi

    Contains RdRp catalytic domain.SAAS annotation
    Contains SF3 helicase domain.SAAS annotation
    Contains SFhelicase domain.SAAS annotation

    Family and domain databases

    Gene3Di2.60.120.20. 3 hits.
    4.10.90.10. 1 hit.
    InterProiIPR015031. Capsid_VP4_Picornavir.
    IPR004080. FMDV_VP1_coat.
    IPR004004. Helic/Pol/Pept_Calicivir-typ.
    IPR000605. Helicase_SF3_ssDNA/RNA_vir.
    IPR014759. Helicase_SF3_ssRNA_vir.
    IPR027417. P-loop_NTPase.
    IPR000199. Peptidase_C3A/C3B_picornavir.
    IPR001676. Picornavirus_capsid.
    IPR001205. RNA-dir_pol_C.
    IPR007094. RNA-dir_pol_PSvirus.
    IPR009003. Trypsin-like_Pept_dom.
    IPR029053. Viral_coat.
    [Graphical view]
    PfamiPF00548. Peptidase_C3. 1 hit.
    PF00680. RdRP_1. 1 hit.
    PF00073. Rhv. 3 hits.
    PF00910. RNA_helicase. 1 hit.
    PF08935. VP4_2. 1 hit.
    [Graphical view]
    PRINTSiPR00918. CALICVIRUSNS.
    PR01542. FMDVP1COAT.
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    PS51218. SF3_HELICASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0QEE1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTTDCFIAV VNAIKEVRAL FLPRTAGKME FTLHDGEKMV FVPYDQEPLN     50
    EGWKASVQRK LKGAGQSSPA TGSQNQSGNT GSIINNYYMQ QYQNSMDTQL 100
    GDNAISGGSN EGSTDTTSAH TTNTQNNDWF SKLASSAFSG LFGALLADKK 150
    TEETTLLEDR ILTTRNGHTT STTQSSVGVT FGYATAEDST SGPNTSGLET 200
    RVHQAERFFK MALFDWVPSQ NFGHMHKVVL PHEPKGVYGG LVKSYAYMRN 250
    GWDVEVTAVG NQFNGGCLLV ALVPEMGDIS DREKYQLTLY PHQFINPRTN 300
    MTAHITVPYV GVNRYDQYKQ HRPWTLVVMV VAPLTTNTAG AQQIKVYANI 350
    APTNVHVAGE LPSKEGIFPV ACSDGYGNMV TTDPKTADPV YGKVYNPPRT 400
    ALPGRFTNYL DVAEACPTFL MFENVPYVST RTDGQRLLAK FDVSLAAKHM 450
    SNTYLAGLAQ YYTQYTGTIN LHFMFTGPTD AKARYMVAYV PPGMDAPDNP 500
    EEAAHCIHAE WDTGLNSKFT FSIPYISAAD YAYTASDKAE TTCVQGWVCV 550
    YQITHGKADA DALVVSASAG KDFELRLPVD ARKQTTTTGE SADPVTTTVE 600
    NYGGETQVQR RHHTDVAFVL DRFVEVTVSG NQHTLDVMQA HKDNIVGALL 650
    RAATYYFSDL EIAVTHTGKL TWVPNGAPVS ALNNTTNPTA YHKGPVTRLA 700
    LPYTAPHRVL ATAYTGTTTY TASARGDLAH LTTTHARHLP TSFNFGAVKA 750
    ETITELLVRM KRAELYCPRP ILPIQPTGDR RKQPLVAPAK QLLNFDLLKL 800
    AGDVESNPGP FFFSDVRSNF SKLVETINQM QEDMSTKHGP DFNRLVSAFE 850
    ELASGVKAIR AGLDEAKPWY KLIKLLSRLS CMAAVAARSK DPVLVAIMLA 900
    DTGLEILDST FVVKKISDSL SSLFHVPAPA FSFGAPILLA GLVKVASSFF 950
    RSTPEDLERA EKQLKARDIN DIFAILKNGE WLVKLILAIR DWIKAWIASE 1000
    EKFVTMTDLV PGILEKQRDL NDPSKYKDAK EWLDNTRQVC LKNGNVHIAN 1050
    LCKVVAPAPS KSRPEPVVVC LRGKSGQGKS FLANVLAQAI STHLTGRTDS 1100
    VWYCPPDPDH FDGYNQQTVV VMDDLGQNPD GKDFKYFAQM VSTTGFIPPM 1150
    ASLEDKGKPF SSKVIIATTN LYSGFTPKTM VCPDALNRRF HFDIDVSAKD 1200
    GYKINNKLDI IKALEDTHAN PVAMFHYDCA LLNGMAVEMK RLQQDVFKPQ 1250
    PPLQNVYQLV QEVIERVELH EKVSSHPIFK QISIPSQKSV LYFLIEKGQH 1300
    EAAIEFFEGM VHDSIKEELR PLIQQTSFVK RAFKRLKENF EIVALCLTLL 1350
    ANIVIMIRET HKRQKMVDDA VNEYIEKANI TTDGQTLDEA EKNPLETSGA 1400
    STVGFRERTL PGQKARDDVD SEPAQPTEEQ PQAEGPYAGP LERQRPLKVR 1450
    AKLPRQEGPY AGPMERQKPL KVKARAPVVK EGPYEGPVKK PVALKVKAKN 1500
    LIVTESGAPP TDLQKMVMGN TKPVELILDG KTVAICCATG VFGTAYLVPR 1550
    HLFAEKYDKI MLDGRALTDS DYRVFEFEIK VKGQDMLSDA ALMVLHRGNR 1600
    VRDITKHFRD VARMKKGTPV VGVINNADVG RLIFSGEALT YKDIVVCMDG 1650
    DTMPGLFAYK AATKAGYCGG AVLAKDGADT FIVGTHSAGG NGVGYCSCVS 1700
    RSMLLKMKAH IDPEPHHEGL IVDTRDVEER VHVMRKTKLA PTVAHGVFNP 1750
    EFGPAALSNK DPRLNEGVVL DEVIFSKHKG DTKMSAEDKA LFRRCAADYA 1800
    SRLHSVLGTA NAPLSIYEAI KGVDGLDAME PDTAPGLPWA LQGKRRGALI 1850
    DFENGTVGPE VEAALKLMEK REYKFACQTF LKDEIRPMEK VRAGKTRIVD 1900
    VLPVEHILYT RMMIGRFCAQ MHSNNGPQIG SAVGCNPDVD WQRFGTHFAQ 1950
    YRNVWDVDYS AFDANHCSDA MNIMFEEVFR TEFGFHPNAE WILKTLVNTE 2000
    HAYENKRITV EGGMPSGCSA TSIINTILNN IYVLYALRRH YEGVELDTYT 2050
    MISYGDDIVV ASDYDLDFEA LKPHFKSLGQ TITPADKSDK GFVLGHSITD 2100
    VTFLKRHFHM DYGTGFYKPV MASKTLEAIL SFARRGTIQE KLISVAGLAV 2150
    HSGPDEYRRL FEPFQGLFEI PSYRSLYLRW VNAVCGDA 2188
    Length:2,188
    Mass (Da):242,089
    Last modified:September 5, 2006 - v1
    Checksum:i05F14D7F81022C7E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ409183 Genomic RNA. Translation: ABD67453.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ409183 Genomic RNA. Translation: ABD67453.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C03.008.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q0QEE1.

    Family and domain databases

    Gene3Di 2.60.120.20. 3 hits.
    4.10.90.10. 1 hit.
    InterProi IPR015031. Capsid_VP4_Picornavir.
    IPR004080. FMDV_VP1_coat.
    IPR004004. Helic/Pol/Pept_Calicivir-typ.
    IPR000605. Helicase_SF3_ssDNA/RNA_vir.
    IPR014759. Helicase_SF3_ssRNA_vir.
    IPR027417. P-loop_NTPase.
    IPR000199. Peptidase_C3A/C3B_picornavir.
    IPR001676. Picornavirus_capsid.
    IPR001205. RNA-dir_pol_C.
    IPR007094. RNA-dir_pol_PSvirus.
    IPR009003. Trypsin-like_Pept_dom.
    IPR029053. Viral_coat.
    [Graphical view ]
    Pfami PF00548. Peptidase_C3. 1 hit.
    PF00680. RdRP_1. 1 hit.
    PF00073. Rhv. 3 hits.
    PF00910. RNA_helicase. 1 hit.
    PF08935. VP4_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00918. CALICVIRUSNS.
    PR01542. FMDVP1COAT.
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    PS51218. SF3_HELICASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dynamics of mutation and recombination in a replicating population of complementing, defective viral genomes."
      Garcia-Arriaza J., Ojosnegros S., Davila M., Domingo E., Escarmis C.
      J. Mol. Biol. 360:558-572(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C-S8p260d417Imported.

    Entry informationi

    Entry nameiQ0QEE1_9PICO
    AccessioniPrimary (citable) accession number: Q0QEE1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)