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Q0QEE1

- Q0QEE1_9PICO

UniProt

Q0QEE1 - Q0QEE1_9PICO

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Protein
Submitted name: Polyprotein
Gene
N/A
Organism
Foot-and-mouth disease virus - type C
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

NTP + H2O = NDP + phosphate.SAAS annotations
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotations
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.SAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1886 – 18861Diphosphate 2
Binding sitei1961 – 19611Diphosphate 2; via amide nitrogen

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW
  3. RNA helicase activity Source: InterPro
  4. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  5. cysteine-type endopeptidase activity Source: InterPro
  6. ion channel activity Source: UniProtKB-KW
  7. structural molecule activity Source: InterPro

GO - Biological processi

  1. pore formation by virus in membrane of host cell Source: UniProtKB-KW
  2. protein oligomerization Source: UniProtKB-KW
  3. transcription, DNA-templated Source: InterPro
  4. viral RNA genome replication Source: InterPro
  5. viral entry into host cell Source: UniProtKB-KW
  6. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotations, Hydrolase, Ion channel, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotations, Thiol proteaseSAAS annotations, Transferase, Viral ion channelSAAS annotations

Keywords - Biological processi

Host-virus interaction, Ion transport, Transport, Viral attachment to host cellSAAS annotations, Viral RNA replicationSAAS annotations, Virus entry into host cell

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-bindingSAAS annotations

Protein family/group databases

MEROPSiC03.008.

Names & Taxonomyi

Protein namesi
Submitted name:
PolyproteinImported
OrganismiFoot-and-mouth disease virus - type CImported
Taxonomic identifieri12116 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeAphthovirus

Subcellular locationi

GO - Cellular componenti

  1. host cell cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  2. icosahedral viral capsid Source: InterPro
  3. integral to membrane of host cell Source: UniProtKB-KW
  4. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotations, Host cytoplasmSAAS annotations, Host cytoplasmic vesicleSAAS annotations, Host membraneSAAS annotations, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6262truncated leader proteaseImported
PRO_5000141359Add
BLAST
Chaini63 – 14785VP4 proteinImported
PRO_5000141360Add
BLAST
Chaini148 – 365218VP2 proteinImported
PRO_5000141361Add
BLAST
Chaini366 – 584219VP3 proteinImported
PRO_5000141362Add
BLAST
Chaini585 – 793209VP1 proteinImported
PRO_5000141363Add
BLAST
Chaini794 – 809162A proteaseImported
PRO_5000141364Add
BLAST
Chaini810 – 9961872B proteinImported
PRO_5000141365Add
BLAST
Chaini997 – 12812852C proteinImported
PRO_5000141366Add
BLAST
Chaini1282 – 14341533A proteinImported
PRO_5000141367Add
BLAST
Chaini1435 – 145723VPg1 proteinImported
PRO_5000141368Add
BLAST
Chaini1458 – 148124VPg2 proteinImported
PRO_5000141369Add
BLAST
Chaini1482 – 150524VPg3 proteinImported
PRO_5000141370Add
BLAST
Chaini1506 – 17182133C proteaseImported
PRO_5000141371Add
BLAST
Chaini1719 – 21884703D polymeraseImported
PRO_5000141372Add
BLAST

Keywords - PTMi

PhosphoproteinSAAS annotations

Structurei

Miscellaneous databases

EvolutionaryTraceiQ0QEE1.

Family & Domainsi

Sequence similaritiesi

Contains RdRp catalytic domain.SAAS annotations
Contains SF3 helicase domain.SAAS annotations
Contains SFhelicase domain.SAAS annotations

Family and domain databases

Gene3Di2.60.120.20. 3 hits.
4.10.90.10. 1 hit.
InterProiIPR015031. Capsid_VP4_Picornavir.
IPR004080. FMDV_VP1_coat.
IPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR000199. Peptidase_C3A/C3B_picornavir.
IPR001676. Picornavirus_capsid.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009003. Trypsin-like_Pept_dom.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00548. Peptidase_C3. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00073. Rhv. 3 hits.
PF00910. RNA_helicase. 1 hit.
PF08935. VP4_2. 1 hit.
[Graphical view]
PRINTSiPR00918. CALICVIRUSNS.
PR01542. FMDVP1COAT.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0QEE1-1 [UniParc]FASTAAdd to Basket

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MNTTDCFIAV VNAIKEVRAL FLPRTAGKME FTLHDGEKMV FVPYDQEPLN     50
EGWKASVQRK LKGAGQSSPA TGSQNQSGNT GSIINNYYMQ QYQNSMDTQL 100
GDNAISGGSN EGSTDTTSAH TTNTQNNDWF SKLASSAFSG LFGALLADKK 150
TEETTLLEDR ILTTRNGHTT STTQSSVGVT FGYATAEDST SGPNTSGLET 200
RVHQAERFFK MALFDWVPSQ NFGHMHKVVL PHEPKGVYGG LVKSYAYMRN 250
GWDVEVTAVG NQFNGGCLLV ALVPEMGDIS DREKYQLTLY PHQFINPRTN 300
MTAHITVPYV GVNRYDQYKQ HRPWTLVVMV VAPLTTNTAG AQQIKVYANI 350
APTNVHVAGE LPSKEGIFPV ACSDGYGNMV TTDPKTADPV YGKVYNPPRT 400
ALPGRFTNYL DVAEACPTFL MFENVPYVST RTDGQRLLAK FDVSLAAKHM 450
SNTYLAGLAQ YYTQYTGTIN LHFMFTGPTD AKARYMVAYV PPGMDAPDNP 500
EEAAHCIHAE WDTGLNSKFT FSIPYISAAD YAYTASDKAE TTCVQGWVCV 550
YQITHGKADA DALVVSASAG KDFELRLPVD ARKQTTTTGE SADPVTTTVE 600
NYGGETQVQR RHHTDVAFVL DRFVEVTVSG NQHTLDVMQA HKDNIVGALL 650
RAATYYFSDL EIAVTHTGKL TWVPNGAPVS ALNNTTNPTA YHKGPVTRLA 700
LPYTAPHRVL ATAYTGTTTY TASARGDLAH LTTTHARHLP TSFNFGAVKA 750
ETITELLVRM KRAELYCPRP ILPIQPTGDR RKQPLVAPAK QLLNFDLLKL 800
AGDVESNPGP FFFSDVRSNF SKLVETINQM QEDMSTKHGP DFNRLVSAFE 850
ELASGVKAIR AGLDEAKPWY KLIKLLSRLS CMAAVAARSK DPVLVAIMLA 900
DTGLEILDST FVVKKISDSL SSLFHVPAPA FSFGAPILLA GLVKVASSFF 950
RSTPEDLERA EKQLKARDIN DIFAILKNGE WLVKLILAIR DWIKAWIASE 1000
EKFVTMTDLV PGILEKQRDL NDPSKYKDAK EWLDNTRQVC LKNGNVHIAN 1050
LCKVVAPAPS KSRPEPVVVC LRGKSGQGKS FLANVLAQAI STHLTGRTDS 1100
VWYCPPDPDH FDGYNQQTVV VMDDLGQNPD GKDFKYFAQM VSTTGFIPPM 1150
ASLEDKGKPF SSKVIIATTN LYSGFTPKTM VCPDALNRRF HFDIDVSAKD 1200
GYKINNKLDI IKALEDTHAN PVAMFHYDCA LLNGMAVEMK RLQQDVFKPQ 1250
PPLQNVYQLV QEVIERVELH EKVSSHPIFK QISIPSQKSV LYFLIEKGQH 1300
EAAIEFFEGM VHDSIKEELR PLIQQTSFVK RAFKRLKENF EIVALCLTLL 1350
ANIVIMIRET HKRQKMVDDA VNEYIEKANI TTDGQTLDEA EKNPLETSGA 1400
STVGFRERTL PGQKARDDVD SEPAQPTEEQ PQAEGPYAGP LERQRPLKVR 1450
AKLPRQEGPY AGPMERQKPL KVKARAPVVK EGPYEGPVKK PVALKVKAKN 1500
LIVTESGAPP TDLQKMVMGN TKPVELILDG KTVAICCATG VFGTAYLVPR 1550
HLFAEKYDKI MLDGRALTDS DYRVFEFEIK VKGQDMLSDA ALMVLHRGNR 1600
VRDITKHFRD VARMKKGTPV VGVINNADVG RLIFSGEALT YKDIVVCMDG 1650
DTMPGLFAYK AATKAGYCGG AVLAKDGADT FIVGTHSAGG NGVGYCSCVS 1700
RSMLLKMKAH IDPEPHHEGL IVDTRDVEER VHVMRKTKLA PTVAHGVFNP 1750
EFGPAALSNK DPRLNEGVVL DEVIFSKHKG DTKMSAEDKA LFRRCAADYA 1800
SRLHSVLGTA NAPLSIYEAI KGVDGLDAME PDTAPGLPWA LQGKRRGALI 1850
DFENGTVGPE VEAALKLMEK REYKFACQTF LKDEIRPMEK VRAGKTRIVD 1900
VLPVEHILYT RMMIGRFCAQ MHSNNGPQIG SAVGCNPDVD WQRFGTHFAQ 1950
YRNVWDVDYS AFDANHCSDA MNIMFEEVFR TEFGFHPNAE WILKTLVNTE 2000
HAYENKRITV EGGMPSGCSA TSIINTILNN IYVLYALRRH YEGVELDTYT 2050
MISYGDDIVV ASDYDLDFEA LKPHFKSLGQ TITPADKSDK GFVLGHSITD 2100
VTFLKRHFHM DYGTGFYKPV MASKTLEAIL SFARRGTIQE KLISVAGLAV 2150
HSGPDEYRRL FEPFQGLFEI PSYRSLYLRW VNAVCGDA 2188
Length:2,188
Mass (Da):242,089
Last modified:September 5, 2006 - v1
Checksum:i05F14D7F81022C7E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ409183 Genomic RNA. Translation: ABD67453.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ409183 Genomic RNA. Translation: ABD67453.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C03.008.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q0QEE1.

Family and domain databases

Gene3Di 2.60.120.20. 3 hits.
4.10.90.10. 1 hit.
InterProi IPR015031. Capsid_VP4_Picornavir.
IPR004080. FMDV_VP1_coat.
IPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR000199. Peptidase_C3A/C3B_picornavir.
IPR001676. Picornavirus_capsid.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009003. Trypsin-like_Pept_dom.
IPR029053. Viral_coat.
[Graphical view ]
Pfami PF00548. Peptidase_C3. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00073. Rhv. 3 hits.
PF00910. RNA_helicase. 1 hit.
PF08935. VP4_2. 1 hit.
[Graphical view ]
PRINTSi PR00918. CALICVIRUSNS.
PR01542. FMDVP1COAT.
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Dynamics of mutation and recombination in a replicating population of complementing, defective viral genomes."
    Garcia-Arriaza J., Ojosnegros S., Davila M., Domingo E., Escarmis C.
    J. Mol. Biol. 360:558-572(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C-S8p260d417Imported.

Entry informationi

Entry nameiQ0QEE1_9PICO
AccessioniPrimary (citable) accession number: Q0QEE1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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