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Protein

Genome polyprotein

Gene
N/A
Organism
Foot-and-mouth disease virus - type C
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NTP + H2O = NDP + phosphate.SAAS annotation
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotation, Hydrolase, Ion channel, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Thiol proteaseSAAS annotation, Transferase, Viral ion channelSAAS annotation

Keywords - Biological processi

Host-virus interaction, Ion transport, Transport, Viral attachment to host cellSAAS annotation, Viral RNA replicationSAAS annotation, Virus entry into host cell

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
OrganismiFoot-and-mouth disease virus - type CImported
Taxonomic identifieri12116 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeAphthovirus

Subcellular locationi

  • Host cytoplasmic vesicle membrane SAAS annotation; Peripheral membrane protein SAAS annotation; Cytoplasmic side SAAS annotation
  • Virion SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Host cytoplasmSAAS annotation, Host cytoplasmic vesicleSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

Structurei

Miscellaneous databases

EvolutionaryTraceiQ0QEE1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1045 – 1209165SF3 helicaseInterPro annotationAdd
BLAST
Domaini1952 – 2070119RdRp catalyticInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the picornaviruses polyprotein family.SAAS annotation
Contains RdRp catalytic domain.SAAS annotation
Contains SF3 helicase domain.SAAS annotation

Family and domain databases

Gene3Di2.60.120.20. 3 hits.
4.10.90.10. 1 hit.
InterProiIPR015031. Capsid_VP4_Picornavir.
IPR004080. FMDV_VP1_coat.
IPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR008739. Peptidase_C28.
IPR000199. Peptidase_C3A/C3B_picornavir.
IPR009003. Peptidase_S1_PA.
IPR001676. Picornavirus_capsid.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF05408. Peptidase_C28. 1 hit.
PF00548. Peptidase_C3. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00073. Rhv. 3 hits.
PF00910. RNA_helicase. 1 hit.
PF08935. VP4_2. 1 hit.
[Graphical view]
PRINTSiPR00918. CALICVIRUSNS.
PR01542. FMDVP1COAT.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0QEE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTDCFIAV VNAIKEVRAL FLPRTAGKME FTLHDGEKMV FVPYDQEPLN
60 70 80 90 100
EGWKASVQRK LKGAGQSSPA TGSQNQSGNT GSIINNYYMQ QYQNSMDTQL
110 120 130 140 150
GDNAISGGSN EGSTDTTSAH TTNTQNNDWF SKLASSAFSG LFGALLADKK
160 170 180 190 200
TEETTLLEDR ILTTRNGHTT STTQSSVGVT FGYATAEDST SGPNTSGLET
210 220 230 240 250
RVHQAERFFK MALFDWVPSQ NFGHMHKVVL PHEPKGVYGG LVKSYAYMRN
260 270 280 290 300
GWDVEVTAVG NQFNGGCLLV ALVPEMGDIS DREKYQLTLY PHQFINPRTN
310 320 330 340 350
MTAHITVPYV GVNRYDQYKQ HRPWTLVVMV VAPLTTNTAG AQQIKVYANI
360 370 380 390 400
APTNVHVAGE LPSKEGIFPV ACSDGYGNMV TTDPKTADPV YGKVYNPPRT
410 420 430 440 450
ALPGRFTNYL DVAEACPTFL MFENVPYVST RTDGQRLLAK FDVSLAAKHM
460 470 480 490 500
SNTYLAGLAQ YYTQYTGTIN LHFMFTGPTD AKARYMVAYV PPGMDAPDNP
510 520 530 540 550
EEAAHCIHAE WDTGLNSKFT FSIPYISAAD YAYTASDKAE TTCVQGWVCV
560 570 580 590 600
YQITHGKADA DALVVSASAG KDFELRLPVD ARKQTTTTGE SADPVTTTVE
610 620 630 640 650
NYGGETQVQR RHHTDVAFVL DRFVEVTVSG NQHTLDVMQA HKDNIVGALL
660 670 680 690 700
RAATYYFSDL EIAVTHTGKL TWVPNGAPVS ALNNTTNPTA YHKGPVTRLA
710 720 730 740 750
LPYTAPHRVL ATAYTGTTTY TASARGDLAH LTTTHARHLP TSFNFGAVKA
760 770 780 790 800
ETITELLVRM KRAELYCPRP ILPIQPTGDR RKQPLVAPAK QLLNFDLLKL
810 820 830 840 850
AGDVESNPGP FFFSDVRSNF SKLVETINQM QEDMSTKHGP DFNRLVSAFE
860 870 880 890 900
ELASGVKAIR AGLDEAKPWY KLIKLLSRLS CMAAVAARSK DPVLVAIMLA
910 920 930 940 950
DTGLEILDST FVVKKISDSL SSLFHVPAPA FSFGAPILLA GLVKVASSFF
960 970 980 990 1000
RSTPEDLERA EKQLKARDIN DIFAILKNGE WLVKLILAIR DWIKAWIASE
1010 1020 1030 1040 1050
EKFVTMTDLV PGILEKQRDL NDPSKYKDAK EWLDNTRQVC LKNGNVHIAN
1060 1070 1080 1090 1100
LCKVVAPAPS KSRPEPVVVC LRGKSGQGKS FLANVLAQAI STHLTGRTDS
1110 1120 1130 1140 1150
VWYCPPDPDH FDGYNQQTVV VMDDLGQNPD GKDFKYFAQM VSTTGFIPPM
1160 1170 1180 1190 1200
ASLEDKGKPF SSKVIIATTN LYSGFTPKTM VCPDALNRRF HFDIDVSAKD
1210 1220 1230 1240 1250
GYKINNKLDI IKALEDTHAN PVAMFHYDCA LLNGMAVEMK RLQQDVFKPQ
1260 1270 1280 1290 1300
PPLQNVYQLV QEVIERVELH EKVSSHPIFK QISIPSQKSV LYFLIEKGQH
1310 1320 1330 1340 1350
EAAIEFFEGM VHDSIKEELR PLIQQTSFVK RAFKRLKENF EIVALCLTLL
1360 1370 1380 1390 1400
ANIVIMIRET HKRQKMVDDA VNEYIEKANI TTDGQTLDEA EKNPLETSGA
1410 1420 1430 1440 1450
STVGFRERTL PGQKARDDVD SEPAQPTEEQ PQAEGPYAGP LERQRPLKVR
1460 1470 1480 1490 1500
AKLPRQEGPY AGPMERQKPL KVKARAPVVK EGPYEGPVKK PVALKVKAKN
1510 1520 1530 1540 1550
LIVTESGAPP TDLQKMVMGN TKPVELILDG KTVAICCATG VFGTAYLVPR
1560 1570 1580 1590 1600
HLFAEKYDKI MLDGRALTDS DYRVFEFEIK VKGQDMLSDA ALMVLHRGNR
1610 1620 1630 1640 1650
VRDITKHFRD VARMKKGTPV VGVINNADVG RLIFSGEALT YKDIVVCMDG
1660 1670 1680 1690 1700
DTMPGLFAYK AATKAGYCGG AVLAKDGADT FIVGTHSAGG NGVGYCSCVS
1710 1720 1730 1740 1750
RSMLLKMKAH IDPEPHHEGL IVDTRDVEER VHVMRKTKLA PTVAHGVFNP
1760 1770 1780 1790 1800
EFGPAALSNK DPRLNEGVVL DEVIFSKHKG DTKMSAEDKA LFRRCAADYA
1810 1820 1830 1840 1850
SRLHSVLGTA NAPLSIYEAI KGVDGLDAME PDTAPGLPWA LQGKRRGALI
1860 1870 1880 1890 1900
DFENGTVGPE VEAALKLMEK REYKFACQTF LKDEIRPMEK VRAGKTRIVD
1910 1920 1930 1940 1950
VLPVEHILYT RMMIGRFCAQ MHSNNGPQIG SAVGCNPDVD WQRFGTHFAQ
1960 1970 1980 1990 2000
YRNVWDVDYS AFDANHCSDA MNIMFEEVFR TEFGFHPNAE WILKTLVNTE
2010 2020 2030 2040 2050
HAYENKRITV EGGMPSGCSA TSIINTILNN IYVLYALRRH YEGVELDTYT
2060 2070 2080 2090 2100
MISYGDDIVV ASDYDLDFEA LKPHFKSLGQ TITPADKSDK GFVLGHSITD
2110 2120 2130 2140 2150
VTFLKRHFHM DYGTGFYKPV MASKTLEAIL SFARRGTIQE KLISVAGLAV
2160 2170 2180
HSGPDEYRRL FEPFQGLFEI PSYRSLYLRW VNAVCGDA
Length:2,188
Mass (Da):242,089
Last modified:September 5, 2006 - v1
Checksum:i05F14D7F81022C7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ409183 Genomic RNA. Translation: ABD67453.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ409183 Genomic RNA. Translation: ABD67453.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ0QEE1.

Family and domain databases

Gene3Di2.60.120.20. 3 hits.
4.10.90.10. 1 hit.
InterProiIPR015031. Capsid_VP4_Picornavir.
IPR004080. FMDV_VP1_coat.
IPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR008739. Peptidase_C28.
IPR000199. Peptidase_C3A/C3B_picornavir.
IPR009003. Peptidase_S1_PA.
IPR001676. Picornavirus_capsid.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF05408. Peptidase_C28. 1 hit.
PF00548. Peptidase_C3. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00073. Rhv. 3 hits.
PF00910. RNA_helicase. 1 hit.
PF08935. VP4_2. 1 hit.
[Graphical view]
PRINTSiPR00918. CALICVIRUSNS.
PR01542. FMDVP1COAT.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Dynamics of mutation and recombination in a replicating population of complementing, defective viral genomes."
    Garcia-Arriaza J., Ojosnegros S., Davila M., Domingo E., Escarmis C.
    J. Mol. Biol. 360:558-572(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C-S8p260d417Imported.

Entry informationi

Entry nameiQ0QEE1_9PICO
AccessioniPrimary (citable) accession number: Q0QEE1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: July 6, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.