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Q0QEE1 (Q0QEE1_9PICO) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Protein attributes

Sequence length2188 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

NTP + H2O = NDP + phosphate. SAAS SAAS000605

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). SAAS SAAS000605

Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. SAAS SAAS000605

Subcellular location

Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity SAAS SAAS000605.

Sequence similarities

Contains RdRp catalytic domain. SAAS SAAS000605

Contains SF3 helicase domain. SAAS SAAS000605

Contains SFhelicase domain. SAAS SAAS000605

Ontologies

Keywords
   Biological processHost-virus interaction
Ion transport
Transport
Viral attachment to host cell SAAS SAAS000605
Viral RNA replication SAAS SAAS000605
Virus entry into host cell
   Cellular componentCapsid protein SAAS SAAS000605
Host cytoplasm SAAS SAAS000605
Host cytoplasmic vesicle SAAS SAAS000605
Host membrane SAAS SAAS000605
Membrane
Virion
   LigandATP-binding
Nucleotide-binding
RNA-binding SAAS SAAS000605
   Molecular functionHelicase SAAS SAAS000605
Hydrolase
Ion channel
Nucleotidyltransferase
Protease
RNA-directed RNA polymerase SAAS SAAS000605
Thiol protease SAAS SAAS000605
Transferase
Viral ion channel SAAS SAAS000605
   PTMPhosphoprotein SAAS SAAS000605
Gene Ontology (GO)
   Biological_processpore formation by virus in membrane of host cell

Inferred from electronic annotation. Source: UniProtKB-KW

protein oligomerization

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: InterPro

viral RNA genome replication

Inferred from electronic annotation. Source: InterPro

viral entry into host cell

Inferred from electronic annotation. Source: UniProtKB-KW

virion attachment to host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell cytoplasmic vesicle membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

icosahedral viral capsid

Inferred from electronic annotation. Source: InterPro

integral to membrane of host cell

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA helicase activity

Inferred from electronic annotation. Source: InterPro

RNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

cysteine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

ion channel activity

Inferred from electronic annotation. Source: UniProtKB-KW

structural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6262truncated leader protease EMBL ABD67453.1
PRO_5000141359
Chain63 – 14785VP4 protein EMBL ABD67453.1
PRO_5000141360
Chain148 – 365218VP2 protein EMBL ABD67453.1
PRO_5000141361
Chain366 – 584219VP3 protein EMBL ABD67453.1
PRO_5000141362
Chain585 – 793209VP1 protein EMBL ABD67453.1
PRO_5000141363
Chain794 – 809162A protease EMBL ABD67453.1
PRO_5000141364
Chain810 – 9961872B protein EMBL ABD67453.1
PRO_5000141365
Chain997 – 12812852C protein EMBL ABD67453.1
PRO_5000141366
Chain1282 – 14341533A protein EMBL ABD67453.1
PRO_5000141367
Chain1435 – 145723VPg1 protein EMBL ABD67453.1
PRO_5000141368
Chain1458 – 148124VPg2 protein EMBL ABD67453.1
PRO_5000141369
Chain1482 – 150524VPg3 protein EMBL ABD67453.1
PRO_5000141370
Chain1506 – 17182133C protease EMBL ABD67453.1
PRO_5000141371
Chain1719 – 21884703D polymerase EMBL ABD67453.1
PRO_5000141372

Sites

Binding site18861Diphosphate 2
Binding site19611Diphosphate 2; via amide nitrogen

Sequences

Sequence LengthMass (Da)Tools
Q0QEE1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 05F14D7F81022C7E

FASTA2,188242,089
        10         20         30         40         50         60 
MNTTDCFIAV VNAIKEVRAL FLPRTAGKME FTLHDGEKMV FVPYDQEPLN EGWKASVQRK 

        70         80         90        100        110        120 
LKGAGQSSPA TGSQNQSGNT GSIINNYYMQ QYQNSMDTQL GDNAISGGSN EGSTDTTSAH 

       130        140        150        160        170        180 
TTNTQNNDWF SKLASSAFSG LFGALLADKK TEETTLLEDR ILTTRNGHTT STTQSSVGVT 

       190        200        210        220        230        240 
FGYATAEDST SGPNTSGLET RVHQAERFFK MALFDWVPSQ NFGHMHKVVL PHEPKGVYGG 

       250        260        270        280        290        300 
LVKSYAYMRN GWDVEVTAVG NQFNGGCLLV ALVPEMGDIS DREKYQLTLY PHQFINPRTN 

       310        320        330        340        350        360 
MTAHITVPYV GVNRYDQYKQ HRPWTLVVMV VAPLTTNTAG AQQIKVYANI APTNVHVAGE 

       370        380        390        400        410        420 
LPSKEGIFPV ACSDGYGNMV TTDPKTADPV YGKVYNPPRT ALPGRFTNYL DVAEACPTFL 

       430        440        450        460        470        480 
MFENVPYVST RTDGQRLLAK FDVSLAAKHM SNTYLAGLAQ YYTQYTGTIN LHFMFTGPTD 

       490        500        510        520        530        540 
AKARYMVAYV PPGMDAPDNP EEAAHCIHAE WDTGLNSKFT FSIPYISAAD YAYTASDKAE 

       550        560        570        580        590        600 
TTCVQGWVCV YQITHGKADA DALVVSASAG KDFELRLPVD ARKQTTTTGE SADPVTTTVE 

       610        620        630        640        650        660 
NYGGETQVQR RHHTDVAFVL DRFVEVTVSG NQHTLDVMQA HKDNIVGALL RAATYYFSDL 

       670        680        690        700        710        720 
EIAVTHTGKL TWVPNGAPVS ALNNTTNPTA YHKGPVTRLA LPYTAPHRVL ATAYTGTTTY 

       730        740        750        760        770        780 
TASARGDLAH LTTTHARHLP TSFNFGAVKA ETITELLVRM KRAELYCPRP ILPIQPTGDR 

       790        800        810        820        830        840 
RKQPLVAPAK QLLNFDLLKL AGDVESNPGP FFFSDVRSNF SKLVETINQM QEDMSTKHGP 

       850        860        870        880        890        900 
DFNRLVSAFE ELASGVKAIR AGLDEAKPWY KLIKLLSRLS CMAAVAARSK DPVLVAIMLA 

       910        920        930        940        950        960 
DTGLEILDST FVVKKISDSL SSLFHVPAPA FSFGAPILLA GLVKVASSFF RSTPEDLERA 

       970        980        990       1000       1010       1020 
EKQLKARDIN DIFAILKNGE WLVKLILAIR DWIKAWIASE EKFVTMTDLV PGILEKQRDL 

      1030       1040       1050       1060       1070       1080 
NDPSKYKDAK EWLDNTRQVC LKNGNVHIAN LCKVVAPAPS KSRPEPVVVC LRGKSGQGKS 

      1090       1100       1110       1120       1130       1140 
FLANVLAQAI STHLTGRTDS VWYCPPDPDH FDGYNQQTVV VMDDLGQNPD GKDFKYFAQM 

      1150       1160       1170       1180       1190       1200 
VSTTGFIPPM ASLEDKGKPF SSKVIIATTN LYSGFTPKTM VCPDALNRRF HFDIDVSAKD 

      1210       1220       1230       1240       1250       1260 
GYKINNKLDI IKALEDTHAN PVAMFHYDCA LLNGMAVEMK RLQQDVFKPQ PPLQNVYQLV 

      1270       1280       1290       1300       1310       1320 
QEVIERVELH EKVSSHPIFK QISIPSQKSV LYFLIEKGQH EAAIEFFEGM VHDSIKEELR 

      1330       1340       1350       1360       1370       1380 
PLIQQTSFVK RAFKRLKENF EIVALCLTLL ANIVIMIRET HKRQKMVDDA VNEYIEKANI 

      1390       1400       1410       1420       1430       1440 
TTDGQTLDEA EKNPLETSGA STVGFRERTL PGQKARDDVD SEPAQPTEEQ PQAEGPYAGP 

      1450       1460       1470       1480       1490       1500 
LERQRPLKVR AKLPRQEGPY AGPMERQKPL KVKARAPVVK EGPYEGPVKK PVALKVKAKN 

      1510       1520       1530       1540       1550       1560 
LIVTESGAPP TDLQKMVMGN TKPVELILDG KTVAICCATG VFGTAYLVPR HLFAEKYDKI 

      1570       1580       1590       1600       1610       1620 
MLDGRALTDS DYRVFEFEIK VKGQDMLSDA ALMVLHRGNR VRDITKHFRD VARMKKGTPV 

      1630       1640       1650       1660       1670       1680 
VGVINNADVG RLIFSGEALT YKDIVVCMDG DTMPGLFAYK AATKAGYCGG AVLAKDGADT 

      1690       1700       1710       1720       1730       1740 
FIVGTHSAGG NGVGYCSCVS RSMLLKMKAH IDPEPHHEGL IVDTRDVEER VHVMRKTKLA 

      1750       1760       1770       1780       1790       1800 
PTVAHGVFNP EFGPAALSNK DPRLNEGVVL DEVIFSKHKG DTKMSAEDKA LFRRCAADYA 

      1810       1820       1830       1840       1850       1860 
SRLHSVLGTA NAPLSIYEAI KGVDGLDAME PDTAPGLPWA LQGKRRGALI DFENGTVGPE 

      1870       1880       1890       1900       1910       1920 
VEAALKLMEK REYKFACQTF LKDEIRPMEK VRAGKTRIVD VLPVEHILYT RMMIGRFCAQ 

      1930       1940       1950       1960       1970       1980 
MHSNNGPQIG SAVGCNPDVD WQRFGTHFAQ YRNVWDVDYS AFDANHCSDA MNIMFEEVFR 

      1990       2000       2010       2020       2030       2040 
TEFGFHPNAE WILKTLVNTE HAYENKRITV EGGMPSGCSA TSIINTILNN IYVLYALRRH 

      2050       2060       2070       2080       2090       2100 
YEGVELDTYT MISYGDDIVV ASDYDLDFEA LKPHFKSLGQ TITPADKSDK GFVLGHSITD 

      2110       2120       2130       2140       2150       2160 
VTFLKRHFHM DYGTGFYKPV MASKTLEAIL SFARRGTIQE KLISVAGLAV HSGPDEYRRL 

      2170       2180 
FEPFQGLFEI PSYRSLYLRW VNAVCGDA 

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References

[1]"Dynamics of mutation and recombination in a replicating population of complementing, defective viral genomes."
Garcia-Arriaza J., Ojosnegros S., Davila M., Domingo E., Escarmis C.
J. Mol. Biol. 360:558-572(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C-S8p260d417 EMBL ABD67453.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ409183 Genomic RNA. Translation: ABD67453.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC03.008.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.120.20. 3 hits.
4.10.90.10. 1 hit.
InterProIPR015031. Capsid_VP4_Picornavir.
IPR004080. FMDV_VP1_coat.
IPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR000199. Peptidase_C3A/C3B_picornavir.
IPR001676. Picornavirus_capsid.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009003. Trypsin-like_Pept_dom.
IPR029053. Viral_coat.
[Graphical view]
PfamPF00548. Peptidase_C3. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00073. Rhv. 3 hits.
PF00910. RNA_helicase. 1 hit.
PF08935. VP4_2. 1 hit.
[Graphical view]
PRINTSPR00918. CALICVIRUSNS.
PR01542. FMDVP1COAT.
SUPFAMSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEPS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ0QEE1.

Entry information

Entry nameQ0QEE1_9PICO
AccessionPrimary (citable) accession number: Q0QEE1
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)