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Q0QEE1

- Q0QEE1_9PICO

UniProt

Q0QEE1 - Q0QEE1_9PICO

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Protein

Genome polyprotein

Gene
N/A
Organism
Foot-and-mouth disease virus - type C
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

Catalytic activityi

NTP + H2O = NDP + phosphate.SAAS annotation
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1886 – 18861Diphosphate 2
Binding sitei1961 – 19611Diphosphate 2; via amide nitrogen

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cysteine-type endopeptidase activity Source: InterPro
  3. ion channel activity Source: UniProtKB-KW
  4. RNA binding Source: UniProtKB-KW
  5. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  6. RNA helicase activity Source: InterPro
  7. structural molecule activity Source: InterPro

GO - Biological processi

  1. pore formation by virus in membrane of host cell Source: UniProtKB-KW
  2. protein oligomerization Source: UniProtKB-KW
  3. transcription, DNA-templated Source: InterPro
  4. viral entry into host cell Source: UniProtKB-KW
  5. viral RNA genome replication Source: InterPro
  6. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotation, Hydrolase, Ion channel, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Thiol proteaseSAAS annotation, Transferase, Viral ion channelSAAS annotation

Keywords - Biological processi

Host-virus interaction, Ion transport, Transport, Viral attachment to host cellSAAS annotation, Viral RNA replicationSAAS annotation, Virus entry into host cell

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-bindingSAAS annotation

Protein family/group databases

MEROPSiC28.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
OrganismiFoot-and-mouth disease virus - type CImported
Taxonomic identifieri12116 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeAphthovirus

Subcellular locationi

Host cytoplasmic vesicle membrane SAAS annotation; Peripheral membrane protein SAAS annotation; Cytoplasmic side SAAS annotation

GO - Cellular componenti

  1. host cell cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  2. icosahedral viral capsid Source: InterPro
  3. integral to membrane of host cell Source: UniProtKB-KW
  4. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Host cytoplasmSAAS annotation, Host cytoplasmic vesicleSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6262truncated leader proteaseImportedPRO_5000141359Add
BLAST
Chaini63 – 14785VP4 proteinImportedPRO_5000141360Add
BLAST
Chaini148 – 365218VP2 proteinImportedPRO_5000141361Add
BLAST
Chaini366 – 584219VP3 proteinImportedPRO_5000141362Add
BLAST
Chaini585 – 793209VP1 proteinImportedPRO_5000141363Add
BLAST
Chaini794 – 809162A proteaseImportedPRO_5000141364Add
BLAST
Chaini810 – 9961872B proteinImportedPRO_5000141365Add
BLAST
Chaini997 – 12812852C proteinImportedPRO_5000141366Add
BLAST
Chaini1282 – 14341533A proteinImportedPRO_5000141367Add
BLAST
Chaini1435 – 145723VPg1 proteinImportedPRO_5000141368Add
BLAST
Chaini1458 – 148124VPg2 proteinImportedPRO_5000141369Add
BLAST
Chaini1482 – 150524VPg3 proteinImportedPRO_5000141370Add
BLAST
Chaini1506 – 17182133C proteaseImportedPRO_5000141371Add
BLAST
Chaini1719 – 21884703D polymeraseImportedPRO_5000141372Add
BLAST

Keywords - PTMi

PhosphoproteinSAAS annotation

Structurei

Miscellaneous databases

EvolutionaryTraceiQ0QEE1.

Family & Domainsi

Sequence similaritiesi

Contains RdRp catalytic domain.SAAS annotation
Contains SF3 helicase domain.SAAS annotation
Contains SFhelicase domain.SAAS annotation

Family and domain databases

Gene3Di2.60.120.20. 3 hits.
4.10.90.10. 1 hit.
InterProiIPR015031. Capsid_VP4_Picornavir.
IPR004080. FMDV_VP1_coat.
IPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR000199. Peptidase_C3A/C3B_picornavir.
IPR001676. Picornavirus_capsid.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009003. Trypsin-like_Pept_dom.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00548. Peptidase_C3. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00073. Rhv. 3 hits.
PF00910. RNA_helicase. 1 hit.
PF08935. VP4_2. 1 hit.
[Graphical view]
PRINTSiPR00918. CALICVIRUSNS.
PR01542. FMDVP1COAT.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0QEE1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTTDCFIAV VNAIKEVRAL FLPRTAGKME FTLHDGEKMV FVPYDQEPLN
60 70 80 90 100
EGWKASVQRK LKGAGQSSPA TGSQNQSGNT GSIINNYYMQ QYQNSMDTQL
110 120 130 140 150
GDNAISGGSN EGSTDTTSAH TTNTQNNDWF SKLASSAFSG LFGALLADKK
160 170 180 190 200
TEETTLLEDR ILTTRNGHTT STTQSSVGVT FGYATAEDST SGPNTSGLET
210 220 230 240 250
RVHQAERFFK MALFDWVPSQ NFGHMHKVVL PHEPKGVYGG LVKSYAYMRN
260 270 280 290 300
GWDVEVTAVG NQFNGGCLLV ALVPEMGDIS DREKYQLTLY PHQFINPRTN
310 320 330 340 350
MTAHITVPYV GVNRYDQYKQ HRPWTLVVMV VAPLTTNTAG AQQIKVYANI
360 370 380 390 400
APTNVHVAGE LPSKEGIFPV ACSDGYGNMV TTDPKTADPV YGKVYNPPRT
410 420 430 440 450
ALPGRFTNYL DVAEACPTFL MFENVPYVST RTDGQRLLAK FDVSLAAKHM
460 470 480 490 500
SNTYLAGLAQ YYTQYTGTIN LHFMFTGPTD AKARYMVAYV PPGMDAPDNP
510 520 530 540 550
EEAAHCIHAE WDTGLNSKFT FSIPYISAAD YAYTASDKAE TTCVQGWVCV
560 570 580 590 600
YQITHGKADA DALVVSASAG KDFELRLPVD ARKQTTTTGE SADPVTTTVE
610 620 630 640 650
NYGGETQVQR RHHTDVAFVL DRFVEVTVSG NQHTLDVMQA HKDNIVGALL
660 670 680 690 700
RAATYYFSDL EIAVTHTGKL TWVPNGAPVS ALNNTTNPTA YHKGPVTRLA
710 720 730 740 750
LPYTAPHRVL ATAYTGTTTY TASARGDLAH LTTTHARHLP TSFNFGAVKA
760 770 780 790 800
ETITELLVRM KRAELYCPRP ILPIQPTGDR RKQPLVAPAK QLLNFDLLKL
810 820 830 840 850
AGDVESNPGP FFFSDVRSNF SKLVETINQM QEDMSTKHGP DFNRLVSAFE
860 870 880 890 900
ELASGVKAIR AGLDEAKPWY KLIKLLSRLS CMAAVAARSK DPVLVAIMLA
910 920 930 940 950
DTGLEILDST FVVKKISDSL SSLFHVPAPA FSFGAPILLA GLVKVASSFF
960 970 980 990 1000
RSTPEDLERA EKQLKARDIN DIFAILKNGE WLVKLILAIR DWIKAWIASE
1010 1020 1030 1040 1050
EKFVTMTDLV PGILEKQRDL NDPSKYKDAK EWLDNTRQVC LKNGNVHIAN
1060 1070 1080 1090 1100
LCKVVAPAPS KSRPEPVVVC LRGKSGQGKS FLANVLAQAI STHLTGRTDS
1110 1120 1130 1140 1150
VWYCPPDPDH FDGYNQQTVV VMDDLGQNPD GKDFKYFAQM VSTTGFIPPM
1160 1170 1180 1190 1200
ASLEDKGKPF SSKVIIATTN LYSGFTPKTM VCPDALNRRF HFDIDVSAKD
1210 1220 1230 1240 1250
GYKINNKLDI IKALEDTHAN PVAMFHYDCA LLNGMAVEMK RLQQDVFKPQ
1260 1270 1280 1290 1300
PPLQNVYQLV QEVIERVELH EKVSSHPIFK QISIPSQKSV LYFLIEKGQH
1310 1320 1330 1340 1350
EAAIEFFEGM VHDSIKEELR PLIQQTSFVK RAFKRLKENF EIVALCLTLL
1360 1370 1380 1390 1400
ANIVIMIRET HKRQKMVDDA VNEYIEKANI TTDGQTLDEA EKNPLETSGA
1410 1420 1430 1440 1450
STVGFRERTL PGQKARDDVD SEPAQPTEEQ PQAEGPYAGP LERQRPLKVR
1460 1470 1480 1490 1500
AKLPRQEGPY AGPMERQKPL KVKARAPVVK EGPYEGPVKK PVALKVKAKN
1510 1520 1530 1540 1550
LIVTESGAPP TDLQKMVMGN TKPVELILDG KTVAICCATG VFGTAYLVPR
1560 1570 1580 1590 1600
HLFAEKYDKI MLDGRALTDS DYRVFEFEIK VKGQDMLSDA ALMVLHRGNR
1610 1620 1630 1640 1650
VRDITKHFRD VARMKKGTPV VGVINNADVG RLIFSGEALT YKDIVVCMDG
1660 1670 1680 1690 1700
DTMPGLFAYK AATKAGYCGG AVLAKDGADT FIVGTHSAGG NGVGYCSCVS
1710 1720 1730 1740 1750
RSMLLKMKAH IDPEPHHEGL IVDTRDVEER VHVMRKTKLA PTVAHGVFNP
1760 1770 1780 1790 1800
EFGPAALSNK DPRLNEGVVL DEVIFSKHKG DTKMSAEDKA LFRRCAADYA
1810 1820 1830 1840 1850
SRLHSVLGTA NAPLSIYEAI KGVDGLDAME PDTAPGLPWA LQGKRRGALI
1860 1870 1880 1890 1900
DFENGTVGPE VEAALKLMEK REYKFACQTF LKDEIRPMEK VRAGKTRIVD
1910 1920 1930 1940 1950
VLPVEHILYT RMMIGRFCAQ MHSNNGPQIG SAVGCNPDVD WQRFGTHFAQ
1960 1970 1980 1990 2000
YRNVWDVDYS AFDANHCSDA MNIMFEEVFR TEFGFHPNAE WILKTLVNTE
2010 2020 2030 2040 2050
HAYENKRITV EGGMPSGCSA TSIINTILNN IYVLYALRRH YEGVELDTYT
2060 2070 2080 2090 2100
MISYGDDIVV ASDYDLDFEA LKPHFKSLGQ TITPADKSDK GFVLGHSITD
2110 2120 2130 2140 2150
VTFLKRHFHM DYGTGFYKPV MASKTLEAIL SFARRGTIQE KLISVAGLAV
2160 2170 2180
HSGPDEYRRL FEPFQGLFEI PSYRSLYLRW VNAVCGDA
Length:2,188
Mass (Da):242,089
Last modified:September 5, 2006 - v1
Checksum:i05F14D7F81022C7E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ409183 Genomic RNA. Translation: ABD67453.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ409183 Genomic RNA. Translation: ABD67453.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C28.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q0QEE1.

Family and domain databases

Gene3Di 2.60.120.20. 3 hits.
4.10.90.10. 1 hit.
InterProi IPR015031. Capsid_VP4_Picornavir.
IPR004080. FMDV_VP1_coat.
IPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR000199. Peptidase_C3A/C3B_picornavir.
IPR001676. Picornavirus_capsid.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009003. Trypsin-like_Pept_dom.
IPR029053. Viral_coat.
[Graphical view ]
Pfami PF00548. Peptidase_C3. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00073. Rhv. 3 hits.
PF00910. RNA_helicase. 1 hit.
PF08935. VP4_2. 1 hit.
[Graphical view ]
PRINTSi PR00918. CALICVIRUSNS.
PR01542. FMDVP1COAT.
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Dynamics of mutation and recombination in a replicating population of complementing, defective viral genomes."
    Garcia-Arriaza J., Ojosnegros S., Davila M., Domingo E., Escarmis C.
    J. Mol. Biol. 360:558-572(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C-S8p260d417Imported.

Entry informationi

Entry nameiQ0QEE1_9PICO
AccessioniPrimary (citable) accession number: Q0QEE1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)