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Protein

Envelope small membrane protein

Gene

E

Organism
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the viral envelope that plays a central role in virus morphogenesis and assembly. It is sufficient to form virus-like particles. Seems to be important for creating the membrane curvature needed to acquire the rounded, stable and infectious particle phenotype. Acts as a viroporin, inducing the formation of hydrophilic pores in cellular membranes. Also induces apoptosis (By similarity).By similarity

Miscellaneous

Bat coronavirus 279/2005 is highly similar to SARS-CoV (SARS-like).

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope small membrane protein
Short name:
E protein
Short name:
sM protein
Gene namesi
Name:E
Synonyms:sM
ORF Names:4
OrganismiBat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
Taxonomic identifieri389167 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiRhinolophus macrotis (Big-eared horseshoe bat) [TaxID: 196889]
Proteomesi
  • UP000006573 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16Virion surfaceSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 76IntravirionSequence analysisAdd BLAST39

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899311 – 76Envelope small membrane proteinAdd BLAST76

Interactioni

Subunit structurei

Homooligomer. Interacts with the M membrane protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex (By similarity).By similarity

Structurei

3D structure databases

SMRiQ0Q473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the coronaviruses E protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG0900022Z.

Family and domain databases

InterProiView protein in InterPro
IPR003873. NS3/E.
PfamiView protein in Pfam
PF02723. NS3_envE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0Q473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSFVSEETG TLIVNSVLLF FAFVVFLLVT LAILTALRLC AYCCNIVNVS
60 70
LVKPTVYVYS RVKNLNSSEG VPDLLV
Length:76
Mass (Da):8,395
Last modified:September 5, 2006 - v1
Checksum:i5CD9A91C52DDA199
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ648857 Genomic RNA. Translation: ABG47071.1.

Similar proteinsi

Entry informationi

Entry nameiVEMP_BC279
AccessioniPrimary (citable) accession number: Q0Q473
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: July 5, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome