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Protein

Membrane protein

Gene

M

Organism
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.By similarity

Miscellaneous

Bat coronavirus 512/2005 is highly similar to porcine epidemic diarrhea virus (PEDV).

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein
Short name:
M protein
Alternative name(s):
E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Gene namesi
Name:M
ORF Names:5
OrganismiBat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005)
Taxonomic identifieri693999 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeAlphacoronavirus
Virus hostiScotophilus kuhlii (Lesser asiatic yellow bat) [TaxID: 153297]
Proteomesi
  • UP000113079 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18Virion surfaceSequence analysisAdd BLAST18
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 49IntravirionSequence analysis10
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 76Virion surfaceSequence analysis6
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 227IntravirionSequence analysisAdd BLAST130

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Viral matrix protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899351 – 227Membrane proteinAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the coronaviruses M protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR002574. Corona_M.
PfamiView protein in Pfam
PF01635. Corona_M. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0Q463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNQSVPVE EVIKHLRNWN FSWNIILTIL LVVLQYGHYK YSRVLYGLKM
60 70 80 90 100
AILWLLWPLV LALSIFDAWA SFNVNWVFFA FSILMACVTA VLWIMYFVNS
110 120 130 140 150
IRLWRRTHSW WSYNPETDSI LSVSVLGRHV CLPILGAPTG VTLTLLNGTL
160 170 180 190 200
LVEGYQVATG VQVNNLPGYV TVAKASTTIV YQRVGRSMNA NSSTGWAFFV
210 220
KSKHGDYYAA ANPTEVVTDS EKILHLV
Length:227
Mass (Da):25,666
Last modified:September 5, 2006 - v1
Checksum:i41CFA6EFC2BB303D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ648858 Genomic RNA. Translation: ABG47081.1.
RefSeqiYP_001351687.1. NC_009657.1.

Genome annotation databases

GeneIDi11266521.
KEGGivg:11266521.

Similar proteinsi

Entry informationi

Entry nameiVME1_BC512
AccessioniPrimary (citable) accession number: Q0Q463
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: May 10, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome