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Protein

Nucleoprotein

Gene

N

Organism
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid. Interaction with the M protein leads to the formation of virus particles. Binds to cellular membranes and phospholipids. Elicits cell-mediated immunity. May play roles in viral transcription and translation, and/or replication.

Miscellaneous

Bat coronavirus 512/2005 is highly similar to porcine epidemic diarrhea virus (PEDV).

GO - Molecular functioni

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
NC
Short name:
Protein N
Gene namesi
Name:N
ORF Names:6
OrganismiBat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005)
Taxonomic identifieri693999 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeAlphacoronavirus
Virus hostiScotophilus kuhlii (Lesser asiatic yellow bat) [TaxID: 153297]
Proteomesi
  • UP000113079 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host Golgi apparatus, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002898841 – 394NucleoproteinAdd BLAST394

Post-translational modificationi

Phosphorylated on serine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ0Q462.

Interactioni

Subunit structurei

Monomer and oligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with the M protein.

Structurei

3D structure databases

ProteinModelPortaliQ0Q462.
SMRiQ0Q462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 159RNA-bindingBy similarityAdd BLAST145
Regioni231 – 340DimerizationBy similarityAdd BLAST110

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR001218. Corona_nucleocap.
IPR037179. Nucleocapsid_C.
IPR037195. Nucleocapsid_N.
PfamiView protein in Pfam
PF00937. Corona_nucleoca. 1 hit.
PIRSFiPIRSF003888. Corona_nucleocap. 1 hit.
SUPFAMiSSF103068. SSF103068. 1 hit.
SSF110304. SSF110304. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0Q462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVKFQPRG RSKGRVPLSL FAPLRVTDEK PLYKVLPNNA VPQGMGGKDQ
60 70 80 90 100
QIGYWVEQQR WRMRRGDRVD LPSNWHFYFL GTGPHSDLPF RKRTDGVFWV
110 120 130 140 150
AIDGAKTQPT GLGVRKSSEK PLVPKFKNKL PNNVEIVEPT TPNNSRANSR
160 170 180 190 200
SRSRGGQSNS RGNSQNRGDK SRNQSRNRSQ SNDRGSDSRD DLVAAVKKAL
210 220 230 240 250
EDLGVGAAKP KGKTQSGKNT PKNKSRSGSV QRAEAKDKPE WRRTPSGDES
260 270 280 290 300
VEVCFGPRGG TRNFGSSEFV AKGVNAPGYA QAASLVPGAA ALLFGGNVAT
310 320 330 340 350
KEMADGVEIT YTYKMLVPKD DKNLEIFLAQ VDAYKLGDPK PQRKVKRSRT
360 370 380 390
PTPKPATEPV YDDVAADPTY ANLEWDTTVE DGVEMINEVF DTQN
Length:394
Mass (Da):43,377
Last modified:September 5, 2006 - v1
Checksum:i1BE30F42AC2411EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ648858 Genomic RNA. Translation: ABG47082.1.
RefSeqiYP_001351688.1. NC_009657.1.

Genome annotation databases

GeneIDi11266522.
KEGGivg:11266522.

Similar proteinsi

Entry informationi

Entry nameiNCAP_BC512
AccessioniPrimary (citable) accession number: Q0Q462
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: October 25, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome