Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q0Q0E4

- GATA4_CANFA

UniProt

Q0Q0E4 - GATA4_CANFA

Protein

Transcription factor GATA-4

Gene

GATA4

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri217 – 24125GATA-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri271 – 29525GATA-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
    3. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
    4. RNA polymerase II transcription factor binding transcription factor activity Source: Ensembl
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. atrial septum secundum morphogenesis Source: Ensembl
    2. atrioventricular valve morphogenesis Source: Ensembl
    3. BMP signaling pathway Source: Ensembl
    4. canonical Wnt signaling pathway Source: Ensembl
    5. cardiac muscle cell differentiation Source: Ensembl
    6. cardiac muscle hypertrophy in response to stress Source: Ensembl
    7. cell-cell signaling Source: Ensembl
    8. cellular response to follicle-stimulating hormone stimulus Source: Ensembl
    9. embryonic digestive tract morphogenesis Source: Ensembl
    10. embryonic foregut morphogenesis Source: Ensembl
    11. embryonic heart tube anterior/posterior pattern specification Source: Ensembl
    12. endocardial cushion development Source: Ensembl
    13. endoderm formation Source: Ensembl
    14. epithelial cell fate commitment Source: Ensembl
    15. gastrulation with mouth forming second Source: Ensembl
    16. intestinal epithelial cell differentiation Source: Ensembl
    17. in utero embryonic development Source: Ensembl
    18. lung lobe formation Source: Ensembl
    19. positive regulation of cardiac muscle cell proliferation Source: Ensembl
    20. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    21. response to drug Source: Ensembl
    22. response to estrogen Source: Ensembl
    23. seminiferous tubule development Source: Ensembl
    24. Sertoli cell differentiation Source: Ensembl
    25. signal transduction involved in regulation of gene expression Source: Ensembl
    26. SMAD protein signal transduction Source: Ensembl
    27. spermatogenesis Source: Ensembl
    28. tube morphogenesis Source: Ensembl
    29. ventricular cardiac muscle tissue development Source: Ensembl

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_182569. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor GATA-4
    Alternative name(s):
    GATA-binding factor 4
    Gene namesi
    Name:GATA4
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 25

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Transcription factor GATA-4PRO_0000289588Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei300 – 3001N6-methyllysine; by EZH2By similarity

    Post-translational modificationi

    Methylation at Lys-300 attenuates transcriptional activity.By similarity

    Keywords - PTMi

    Methylation

    Interactioni

    Subunit structurei

    Interacts with ZNF260 By similarity. Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4 and LMCD1. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. Interacts with NR5A1 and ZFPM2 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000011776.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0Q0E4.
    SMRiQ0Q0E4. Positions 212-256, 265-320.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi118 – 1269Poly-Ala
    Compositional biasi174 – 1818Poly-Ala
    Compositional biasi276 – 2805Poly-Thr

    Sequence similaritiesi

    Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri217 – 24125GATA-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri271 – 29525GATA-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5641.
    GeneTreeiENSGT00750000117615.
    HOGENOMiHOG000047700.
    HOVERGENiHBG051703.
    InParanoidiQ0Q0E4.
    KOiK09183.
    OMAiSPGWSQA.
    OrthoDBiEOG7CCBRF.
    TreeFamiTF315391.

    Family and domain databases

    Gene3Di3.30.50.10. 2 hits.
    InterProiIPR008013. GATA_N.
    IPR028436. TF_GATA_4.
    IPR016375. TF_GATA_4/5/6.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PANTHERiPTHR10071:SF154. PTHR10071:SF154. 1 hit.
    PfamiPF00320. GATA. 2 hits.
    PF05349. GATA-N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003028. TF_GATA_4/5/6. 1 hit.
    PRINTSiPR00619. GATAZNFINGER.
    SMARTiSM00401. ZnF_GATA. 2 hits.
    [Graphical view]
    PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
    PS50114. GATA_ZN_FINGER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0Q0E4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYQSLAMAAN HGPPPGAYEA GGPGAFMHGA GAASSPVYVP TPRVPSSVLG    50
    LSYLQGGGGA AASGASSGGG SGGAPSAAGP GAQQGSPGWS QAGADGAAYT 100
    PPPVSPRFSF PGTTGSLAAA AAAAAAREAA AYGGGGGAAG AGLAGREQYG 150
    RAGFAGSYSS PYPAYMADVG ASWAAAAAAS AGPFDSPVLH SLPGRANPAA 200
    RHPNLDMFDD FSEGRECVNC GAMSTPLWRR DGTGHYLCNA CGLYHKMNGI 250
    NRPLIKPQRR LSASRRVGLS CANCQTTTTT LWRRNAEGEP VCNACGLYMK 300
    LHGVPRPLAM RKEGIQTRKR KPKNLNKSKT PAGPSGGESL PPASSASSNS 350
    SNVATSSSEE MRPIKTEPGL SSHYGHSSSM SQTFSVSAMS GHGPSIHPVL 400
    SALKLSPQGY TSSVSQSPQA SSKQDPWNSL ALADSHGDII TA 442
    Length:442
    Mass (Da):44,487
    Last modified:September 5, 2006 - v1
    Checksum:i1CF7F807586FC991
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ666280 mRNA. Translation: ABG75570.1.
    RefSeqiNP_001041577.1. NM_001048112.1.
    XP_005635679.1. XM_005635622.1.
    UniGeneiCfa.39074.

    Genome annotation databases

    EnsembliENSCAFT00000048684; ENSCAFP00000038219; ENSCAFG00000029087.
    GeneIDi486079.
    KEGGicfa:486079.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ666280 mRNA. Translation: ABG75570.1 .
    RefSeqi NP_001041577.1. NM_001048112.1.
    XP_005635679.1. XM_005635622.1.
    UniGenei Cfa.39074.

    3D structure databases

    ProteinModelPortali Q0Q0E4.
    SMRi Q0Q0E4. Positions 212-256, 265-320.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000011776.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000048684 ; ENSCAFP00000038219 ; ENSCAFG00000029087 .
    GeneIDi 486079.
    KEGGi cfa:486079.

    Organism-specific databases

    CTDi 2626.

    Phylogenomic databases

    eggNOGi COG5641.
    GeneTreei ENSGT00750000117615.
    HOGENOMi HOG000047700.
    HOVERGENi HBG051703.
    InParanoidi Q0Q0E4.
    KOi K09183.
    OMAi SPGWSQA.
    OrthoDBi EOG7CCBRF.
    TreeFami TF315391.

    Enzyme and pathway databases

    Reactomei REACT_182569. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    NextBioi 20859925.

    Family and domain databases

    Gene3Di 3.30.50.10. 2 hits.
    InterProi IPR008013. GATA_N.
    IPR028436. TF_GATA_4.
    IPR016375. TF_GATA_4/5/6.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    PANTHERi PTHR10071:SF154. PTHR10071:SF154. 1 hit.
    Pfami PF00320. GATA. 2 hits.
    PF05349. GATA-N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003028. TF_GATA_4/5/6. 1 hit.
    PRINTSi PR00619. GATAZNFINGER.
    SMARTi SM00401. ZnF_GATA. 2 hits.
    [Graphical view ]
    PROSITEi PS00344. GATA_ZN_FINGER_1. 2 hits.
    PS50114. GATA_ZN_FINGER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular screening of GATA4 gene in canine atrial septal defects."
      Hyun C., Lee S.-A., Lee S.-G.
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGATA4_CANFA
    AccessioniPrimary (citable) accession number: Q0Q0E4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3