Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Forkhead box P2 variant 3

Gene

FOXP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

TranscriptionSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Forkhead box P2 variant 3Imported
Submitted name:
Forkhead box protein P2Imported
Gene namesi
Name:FOXP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:13875. FOXP2.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128573.

PTM / Processingi

Proteomic databases

MaxQBiQ0PRL4.
PeptideAtlasiQ0PRL4.
PRIDEiQ0PRL4.

Expressioni

Gene expression databases

BgeeiENSG00000128573.
ExpressionAtlasiQ0PRL4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386200.

Structurei

3D structure databases

ProteinModelPortaliQ0PRL4.
SMRiQ0PRL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini331 – 392Fork-head DNA-bindingInterPro annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili49 – 99Sequence analysisAdd BLAST51

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4385. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032354. FOXP-CC.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16159. FOXP-CC. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0PRL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTPQVITPQ QMQQILQQQV LSPQQLQALL QQQQAVMLQQ QQLQEFYKKQ
60 70 80 90 100
QEQLHLQLLQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQH
110 120 130 140 150
PGKQAKEQQQ QQQQQQQLAA QQLVFQQQLL QMQQLQQQQH LLSLQRQGLI
160 170 180 190 200
SIPPGQAALP VQSLPQAGLS PAEIQQLWKE VTGVHSMEDN GIKHGGLDLT
210 220 230 240 250
TNNSSSTTSS NTSKASPPIT HHSIVNGQSS VLSARRDSSS HEETGASHTL
260 270 280 290 300
YGHGVCKWPG CESICEDFGQ FLKHLNNEHA LDDRSTAQCR VQMQVVQQLE
310 320 330 340 350
IQLSKERERL QAMMTHLHMR PSEPKPSPKP AIMESSDRQL TLNEIYSWFT
360 370 380 390 400
RTFAYFRRNA ATWKNAVRHN LSLHKCFVRV ENVKGAVWTV DEVEYQKRRS
410 420 430 440 450
QKITGSPTLV KNIPTSLGYG AALNASLQAA LAESSLPLLS NPGLINNASS
460 470 480 490 500
GLLQAVHEDL NGSLDHIDSN GNSSPGCSPQ PHIHSIHVKE EPVIAEDEDC
510 520 530
PMSLVTTANH SPELEDDREI EEEPLSEDLE
Length:530
Mass (Da):59,922
Last modified:September 5, 2006 - v1
Checksum:i667D6EFD3F3312F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073626 Genomic DNA. No translation available.
AC074000 Genomic DNA. No translation available.
AC092148 Genomic DNA. No translation available.
AC092606 Genomic DNA. No translation available.
KF458557 Genomic DNA. No translation available.
KF458560 Genomic DNA. No translation available.
KF458565 Genomic DNA. No translation available.
DQ778626 mRNA. Translation: ABG77460.1.
UniGeneiHs.282787.

Genome annotation databases

EnsembliENST00000393491; ENSP00000377130; ENSG00000128573.
UCSCiuc064hfd.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073626 Genomic DNA. No translation available.
AC074000 Genomic DNA. No translation available.
AC092148 Genomic DNA. No translation available.
AC092606 Genomic DNA. No translation available.
KF458557 Genomic DNA. No translation available.
KF458560 Genomic DNA. No translation available.
KF458565 Genomic DNA. No translation available.
DQ778626 mRNA. Translation: ABG77460.1.
UniGeneiHs.282787.

3D structure databases

ProteinModelPortaliQ0PRL4.
SMRiQ0PRL4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386200.

Proteomic databases

MaxQBiQ0PRL4.
PeptideAtlasiQ0PRL4.
PRIDEiQ0PRL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393491; ENSP00000377130; ENSG00000128573.
UCSCiuc064hfd.1. human.

Organism-specific databases

HGNCiHGNC:13875. FOXP2.
OpenTargetsiENSG00000128573.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4385. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.

Miscellaneous databases

ChiTaRSiFOXP2. human.

Gene expression databases

BgeeiENSG00000128573.
ExpressionAtlasiQ0PRL4. baseline and differential.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032354. FOXP-CC.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16159. FOXP-CC. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ0PRL4_HUMAN
AccessioniPrimary (citable) accession number: Q0PRL4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.