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Protein

Elongator complex protein 6

Gene

ELP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_264245. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 6
Alternative name(s):
Angiotonin-transactivated protein 1
Protein TMEM103
Gene namesi
Name:ELP6
Synonyms:ATP1, C3orf75, TMEM103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25976. ELP6.

Subcellular locationi

GO - Cellular componenti

  • Elongator holoenzyme complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717260.

Polymorphism and mutation databases

BioMutaiELP6.
DMDMi121940398.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Elongator complex protein 6PRO_0000274360Add
BLAST

Proteomic databases

MaxQBiQ0PNE2.
PaxDbiQ0PNE2.
PRIDEiQ0PNE2.

PTM databases

PhosphoSiteiQ0PNE2.

Expressioni

Gene expression databases

BgeeiQ0PNE2.
ExpressionAtlasiQ0PNE2. baseline and differential.
GenevisibleiQ0PNE2. HS.

Organism-specific databases

HPAiHPA046358.

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6.1 Publication

Protein-protein interaction databases

BioGridi120209. 12 interactions.
IntActiQ0PNE2. 3 interactions.
STRINGi9606.ENSP00000296149.

Structurei

3D structure databases

ProteinModelPortaliQ0PNE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELP6 family.Curated

Phylogenomic databases

eggNOGiNOG258199.
GeneTreeiENSGT00390000011734.
HOGENOMiHOG000068138.
HOVERGENiHBG103008.
InParanoidiQ0PNE2.
OMAiSFFAKGM.
OrthoDBiEOG7327Q1.
PhylomeDBiQ0PNE2.
TreeFamiTF331346.

Family and domain databases

InterProiIPR018627. UPF0405.
[Graphical view]
PfamiPF09807. DUF2348. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0PNE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFVELNNLLN TTPDRAEQGK LTLLCDAKTD GSFLVHHFLS FYLKANCKVC
60 70 80 90 100
FVALIQSFSH YSIVGQKLGV SLTMARERGQ LVFLEGLKSA VDVVFQAQKE
110 120 130 140 150
PHPLQFLREA NAGNLKPLFE FVREALKPVD SGEARWTYPV LLVDDLSVLL
160 170 180 190 200
SLGMGAVAVL DFIHYCRATV CWELKGNMVV LVHDSGDAED EENDILLNGL
210 220 230 240 250
SHQSHLILRA EGLATGFCRD VHGQLRILWR RPSQPAVHRD QSFTYQYKIQ
260
DKSVSFFAKG MSPAVL
Length:266
Mass (Da):29,793
Last modified:October 31, 2006 - v1
Checksum:i49D96C1484446FB0
GO
Isoform 2 (identifier: Q0PNE2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-250: LRILWRRPSQPAVHRDQSFTYQYKIQ → VCRGLLGNGLLARVPVILDYIGESQA
     251-266: Missing.

Note: No experimental confirmation available.
Show »
Length:250
Mass (Da):27,567
Checksum:i8F498821A14458CE
GO

Sequence cautioni

The sequence AAH00623.1 differs from that shown. Reason: Frameshift at position 256. Curated
The sequence AAH14204.1 differs from that shown. Reason: Frameshift at position 256. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei225 – 25026LRILW…QYKIQ → VCRGLLGNGLLARVPVILDY IGESQA in isoform 2. 1 PublicationVSP_022721Add
BLAST
Alternative sequencei251 – 26616Missing in isoform 2. 1 PublicationVSP_022722Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ787088 mRNA. Translation: ABG79574.1.
AK000218 mRNA. Translation: BAA91017.1.
BC000623 mRNA. Translation: AAH00623.1. Frameshift.
BC014204 mRNA. Translation: AAH14204.1. Frameshift.
CCDSiCCDS43082.1. [Q0PNE2-1]
RefSeqiNP_001026873.2. NM_001031703.2. [Q0PNE2-1]
UniGeneiHs.311100.

Genome annotation databases

EnsembliENST00000296149; ENSP00000296149; ENSG00000163832.
GeneIDi54859.
KEGGihsa:54859.
UCSCiuc003crk.3. human. [Q0PNE2-1]
uc003crl.1. human. [Q0PNE2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ787088 mRNA. Translation: ABG79574.1.
AK000218 mRNA. Translation: BAA91017.1.
BC000623 mRNA. Translation: AAH00623.1. Frameshift.
BC014204 mRNA. Translation: AAH14204.1. Frameshift.
CCDSiCCDS43082.1. [Q0PNE2-1]
RefSeqiNP_001026873.2. NM_001031703.2. [Q0PNE2-1]
UniGeneiHs.311100.

3D structure databases

ProteinModelPortaliQ0PNE2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120209. 12 interactions.
IntActiQ0PNE2. 3 interactions.
STRINGi9606.ENSP00000296149.

PTM databases

PhosphoSiteiQ0PNE2.

Polymorphism and mutation databases

BioMutaiELP6.
DMDMi121940398.

Proteomic databases

MaxQBiQ0PNE2.
PaxDbiQ0PNE2.
PRIDEiQ0PNE2.

Protocols and materials databases

DNASUi54859.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296149; ENSP00000296149; ENSG00000163832.
GeneIDi54859.
KEGGihsa:54859.
UCSCiuc003crk.3. human. [Q0PNE2-1]
uc003crl.1. human. [Q0PNE2-2]

Organism-specific databases

CTDi54859.
GeneCardsiGC03M047537.
HGNCiHGNC:25976. ELP6.
HPAiHPA046358.
MIMi615020. gene.
neXtProtiNX_Q0PNE2.
PharmGKBiPA164717260.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG258199.
GeneTreeiENSGT00390000011734.
HOGENOMiHOG000068138.
HOVERGENiHBG103008.
InParanoidiQ0PNE2.
OMAiSFFAKGM.
OrthoDBiEOG7327Q1.
PhylomeDBiQ0PNE2.
TreeFamiTF331346.

Enzyme and pathway databases

ReactomeiREACT_264245. HATs acetylate histones.

Miscellaneous databases

GenomeRNAii54859.
NextBioi57736.
PROiQ0PNE2.
SOURCEiSearch...

Gene expression databases

BgeeiQ0PNE2.
ExpressionAtlasiQ0PNE2. baseline and differential.
GenevisibleiQ0PNE2. HS.

Family and domain databases

InterProiIPR018627. UPF0405.
[Graphical view]
PfamiPF09807. DUF2348. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Screening the cirrhosis related genes by microarray."
    Liu X., Wei H., Chen J.
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon mucosa.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  4. "DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator."
    Close P., Gillard M., Ladang A., Jiang Z., Papuga J., Hawkes N., Nguyen L., Chapelle J.P., Bouillenne F., Svejstrup J., Fillet M., Chariot A.
    J. Biol. Chem. 287:32535-32545(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RNA POLYMERASE II ELONGATOR COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiELP6_HUMAN
AccessioniPrimary (citable) accession number: Q0PNE2
Secondary accession number(s): Q9BW57, Q9NXJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 31, 2006
Last modified: July 22, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.