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Q0PNE2 (ELP6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongator complex protein 6
Alternative name(s):
Angiotonin-transactivated protein 1
Protein TMEM103
Gene names
Name:ELP6
Synonyms:ATP1, C3orf75, TMEM103
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration.

Subunit structure

Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6. Ref.4

Sequence similarities

Belongs to the ELP6 family.

Sequence caution

The sequence AAH00623.1 differs from that shown. Reason: Frameshift at position 256.

The sequence AAH14204.1 differs from that shown. Reason: Frameshift at position 256.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q0PNE2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q0PNE2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     225-250: LRILWRRPSQPAVHRDQSFTYQYKIQ → VCRGLLGNGLLARVPVILDYIGESQA
     251-266: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Elongator complex protein 6
PRO_0000274360

Natural variations

Alternative sequence225 – 25026LRILW…QYKIQ → VCRGLLGNGLLARVPVILDY IGESQA in isoform 2.
VSP_022721
Alternative sequence251 – 26616Missing in isoform 2.
VSP_022722

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: 49D96C1484446FB0

FASTA26629,793
        10         20         30         40         50         60 
MFVELNNLLN TTPDRAEQGK LTLLCDAKTD GSFLVHHFLS FYLKANCKVC FVALIQSFSH 

        70         80         90        100        110        120 
YSIVGQKLGV SLTMARERGQ LVFLEGLKSA VDVVFQAQKE PHPLQFLREA NAGNLKPLFE 

       130        140        150        160        170        180 
FVREALKPVD SGEARWTYPV LLVDDLSVLL SLGMGAVAVL DFIHYCRATV CWELKGNMVV 

       190        200        210        220        230        240 
LVHDSGDAED EENDILLNGL SHQSHLILRA EGLATGFCRD VHGQLRILWR RPSQPAVHRD 

       250        260 
QSFTYQYKIQ DKSVSFFAKG MSPAVL 

« Hide

Isoform 2 [UniParc].

Checksum: 8F498821A14458CE
Show »

FASTA25027,567

References

« Hide 'large scale' references
[1]"Screening the cirrhosis related genes by microarray."
Liu X., Wei H., Chen J.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Liver.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Colon mucosa.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Skin.
[4]"DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator."
Close P., Gillard M., Ladang A., Jiang Z., Papuga J., Hawkes N., Nguyen L., Chapelle J.P., Bouillenne F., Svejstrup J., Fillet M., Chariot A.
J. Biol. Chem. 287:32535-32545(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE RNA POLYMERASE II ELONGATOR COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[5]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ787088 mRNA. Translation: ABG79574.1.
AK000218 mRNA. Translation: BAA91017.1.
BC000623 mRNA. Translation: AAH00623.1. Frameshift.
BC014204 mRNA. Translation: AAH14204.1. Frameshift.
CCDSCCDS43082.1. [Q0PNE2-1]
RefSeqNP_001026873.2. NM_001031703.2. [Q0PNE2-1]
UniGeneHs.311100.

3D structure databases

ProteinModelPortalQ0PNE2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120209. 5 interactions.
IntActQ0PNE2. 3 interactions.

PTM databases

PhosphoSiteQ0PNE2.

Polymorphism databases

DMDM121940398.

Proteomic databases

MaxQBQ0PNE2.
PaxDbQ0PNE2.
PRIDEQ0PNE2.

Protocols and materials databases

DNASU54859.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296149; ENSP00000296149; ENSG00000163832. [Q0PNE2-1]
GeneID54859.
KEGGhsa:54859.
UCSCuc003crk.3. human. [Q0PNE2-1]
uc003crl.1. human. [Q0PNE2-2]

Organism-specific databases

CTD54859.
GeneCardsGC03M047537.
HGNCHGNC:25976. ELP6.
HPAHPA046358.
MIM615020. gene.
neXtProtNX_Q0PNE2.
PharmGKBPA164717260.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG258199.
HOGENOMHOG000068138.
HOVERGENHBG103008.
OMASFFAKGM.
OrthoDBEOG7327Q1.
PhylomeDBQ0PNE2.
TreeFamTF331346.

Enzyme and pathway databases

ReactomeREACT_172623. Chromatin organization.

Gene expression databases

ArrayExpressQ0PNE2.
BgeeQ0PNE2.
GenevestigatorQ0PNE2.

Family and domain databases

InterProIPR018627. UPF0405.
[Graphical view]
PfamPF09807. DUF2348. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSC3orf75. human.
GenomeRNAi54859.
NextBio57736.
PROQ0PNE2.
SOURCESearch...

Entry information

Entry nameELP6_HUMAN
AccessionPrimary (citable) accession number: Q0PNE2
Secondary accession number(s): Q9BW57, Q9NXJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 31, 2006
Last modified: July 9, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM