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Q0PNE2

- ELP6_HUMAN

UniProt

Q0PNE2 - ELP6_HUMAN

Protein

Elongator complex protein 6

Gene

ELP6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration.

    GO - Biological processi

    1. chromatin organization Source: Reactome
    2. positive regulation of cell migration Source: UniProtKB
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_172610. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongator complex protein 6
    Alternative name(s):
    Angiotonin-transactivated protein 1
    Protein TMEM103
    Gene namesi
    Name:ELP6
    Synonyms:ATP1, C3orf75, TMEM103
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:25976. ELP6.

    Subcellular locationi

    GO - Cellular componenti

    1. Elongator holoenzyme complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164717260.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Elongator complex protein 6PRO_0000274360Add
    BLAST

    Proteomic databases

    MaxQBiQ0PNE2.
    PaxDbiQ0PNE2.
    PRIDEiQ0PNE2.

    PTM databases

    PhosphoSiteiQ0PNE2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ0PNE2.
    BgeeiQ0PNE2.
    GenevestigatoriQ0PNE2.

    Organism-specific databases

    HPAiHPA046358.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6.1 Publication

    Protein-protein interaction databases

    BioGridi120209. 5 interactions.
    IntActiQ0PNE2. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0PNE2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ELP6 family.Curated

    Phylogenomic databases

    eggNOGiNOG258199.
    HOGENOMiHOG000068138.
    HOVERGENiHBG103008.
    OMAiSFFAKGM.
    OrthoDBiEOG7327Q1.
    PhylomeDBiQ0PNE2.
    TreeFamiTF331346.

    Family and domain databases

    InterProiIPR018627. UPF0405.
    [Graphical view]
    PfamiPF09807. DUF2348. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q0PNE2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFVELNNLLN TTPDRAEQGK LTLLCDAKTD GSFLVHHFLS FYLKANCKVC    50
    FVALIQSFSH YSIVGQKLGV SLTMARERGQ LVFLEGLKSA VDVVFQAQKE 100
    PHPLQFLREA NAGNLKPLFE FVREALKPVD SGEARWTYPV LLVDDLSVLL 150
    SLGMGAVAVL DFIHYCRATV CWELKGNMVV LVHDSGDAED EENDILLNGL 200
    SHQSHLILRA EGLATGFCRD VHGQLRILWR RPSQPAVHRD QSFTYQYKIQ 250
    DKSVSFFAKG MSPAVL 266
    Length:266
    Mass (Da):29,793
    Last modified:October 31, 2006 - v1
    Checksum:i49D96C1484446FB0
    GO
    Isoform 2 (identifier: Q0PNE2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         225-250: LRILWRRPSQPAVHRDQSFTYQYKIQ → VCRGLLGNGLLARVPVILDYIGESQA
         251-266: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:250
    Mass (Da):27,567
    Checksum:i8F498821A14458CE
    GO

    Sequence cautioni

    The sequence AAH00623.1 differs from that shown. Reason: Frameshift at position 256.
    The sequence AAH14204.1 differs from that shown. Reason: Frameshift at position 256.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei225 – 25026LRILW…QYKIQ → VCRGLLGNGLLARVPVILDY IGESQA in isoform 2. 1 PublicationVSP_022721Add
    BLAST
    Alternative sequencei251 – 26616Missing in isoform 2. 1 PublicationVSP_022722Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ787088 mRNA. Translation: ABG79574.1.
    AK000218 mRNA. Translation: BAA91017.1.
    BC000623 mRNA. Translation: AAH00623.1. Frameshift.
    BC014204 mRNA. Translation: AAH14204.1. Frameshift.
    CCDSiCCDS43082.1. [Q0PNE2-1]
    RefSeqiNP_001026873.2. NM_001031703.2. [Q0PNE2-1]
    UniGeneiHs.311100.

    Genome annotation databases

    EnsembliENST00000296149; ENSP00000296149; ENSG00000163832. [Q0PNE2-1]
    GeneIDi54859.
    KEGGihsa:54859.
    UCSCiuc003crk.3. human. [Q0PNE2-1]
    uc003crl.1. human. [Q0PNE2-2]

    Polymorphism databases

    DMDMi121940398.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ787088 mRNA. Translation: ABG79574.1 .
    AK000218 mRNA. Translation: BAA91017.1 .
    BC000623 mRNA. Translation: AAH00623.1 . Frameshift.
    BC014204 mRNA. Translation: AAH14204.1 . Frameshift.
    CCDSi CCDS43082.1. [Q0PNE2-1 ]
    RefSeqi NP_001026873.2. NM_001031703.2. [Q0PNE2-1 ]
    UniGenei Hs.311100.

    3D structure databases

    ProteinModelPortali Q0PNE2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120209. 5 interactions.
    IntActi Q0PNE2. 3 interactions.

    PTM databases

    PhosphoSitei Q0PNE2.

    Polymorphism databases

    DMDMi 121940398.

    Proteomic databases

    MaxQBi Q0PNE2.
    PaxDbi Q0PNE2.
    PRIDEi Q0PNE2.

    Protocols and materials databases

    DNASUi 54859.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296149 ; ENSP00000296149 ; ENSG00000163832 . [Q0PNE2-1 ]
    GeneIDi 54859.
    KEGGi hsa:54859.
    UCSCi uc003crk.3. human. [Q0PNE2-1 ]
    uc003crl.1. human. [Q0PNE2-2 ]

    Organism-specific databases

    CTDi 54859.
    GeneCardsi GC03M047537.
    HGNCi HGNC:25976. ELP6.
    HPAi HPA046358.
    MIMi 615020. gene.
    neXtProti NX_Q0PNE2.
    PharmGKBi PA164717260.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258199.
    HOGENOMi HOG000068138.
    HOVERGENi HBG103008.
    OMAi SFFAKGM.
    OrthoDBi EOG7327Q1.
    PhylomeDBi Q0PNE2.
    TreeFami TF331346.

    Enzyme and pathway databases

    Reactomei REACT_172610. HATs acetylate histones.

    Miscellaneous databases

    ChiTaRSi C3orf75. human.
    GenomeRNAii 54859.
    NextBioi 57736.
    PROi Q0PNE2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q0PNE2.
    Bgeei Q0PNE2.
    Genevestigatori Q0PNE2.

    Family and domain databases

    InterProi IPR018627. UPF0405.
    [Graphical view ]
    Pfami PF09807. DUF2348. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Screening the cirrhosis related genes by microarray."
      Liu X., Wei H., Chen J.
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Colon mucosa.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    4. "DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator."
      Close P., Gillard M., Ladang A., Jiang Z., Papuga J., Hawkes N., Nguyen L., Chapelle J.P., Bouillenne F., Svejstrup J., Fillet M., Chariot A.
      J. Biol. Chem. 287:32535-32545(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RNA POLYMERASE II ELONGATOR COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiELP6_HUMAN
    AccessioniPrimary (citable) accession number: Q0PNE2
    Secondary accession number(s): Q9BW57, Q9NXJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3