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Q0PNE2

- ELP6_HUMAN

UniProt

Q0PNE2 - ELP6_HUMAN

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Protein

Elongator complex protein 6

Gene

ELP6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration.

GO - Biological processi

  1. chromatin organization Source: Reactome
  2. positive regulation of cell migration Source: UniProtKB
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_172610. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 6
Alternative name(s):
Angiotonin-transactivated protein 1
Protein TMEM103
Gene namesi
Name:ELP6
Synonyms:ATP1, C3orf75, TMEM103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:25976. ELP6.

Subcellular locationi

GO - Cellular componenti

  1. Elongator holoenzyme complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717260.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Elongator complex protein 6PRO_0000274360Add
BLAST

Proteomic databases

MaxQBiQ0PNE2.
PaxDbiQ0PNE2.
PRIDEiQ0PNE2.

PTM databases

PhosphoSiteiQ0PNE2.

Expressioni

Gene expression databases

BgeeiQ0PNE2.
ExpressionAtlasiQ0PNE2. baseline and differential.
GenevestigatoriQ0PNE2.

Organism-specific databases

HPAiHPA046358.

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6.1 Publication

Protein-protein interaction databases

BioGridi120209. 13 interactions.
IntActiQ0PNE2. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ0PNE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELP6 family.Curated

Phylogenomic databases

eggNOGiNOG258199.
GeneTreeiENSGT00390000011734.
HOGENOMiHOG000068138.
HOVERGENiHBG103008.
InParanoidiQ0PNE2.
OMAiSFFAKGM.
OrthoDBiEOG7327Q1.
PhylomeDBiQ0PNE2.
TreeFamiTF331346.

Family and domain databases

InterProiIPR018627. UPF0405.
[Graphical view]
PfamiPF09807. DUF2348. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q0PNE2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFVELNNLLN TTPDRAEQGK LTLLCDAKTD GSFLVHHFLS FYLKANCKVC
60 70 80 90 100
FVALIQSFSH YSIVGQKLGV SLTMARERGQ LVFLEGLKSA VDVVFQAQKE
110 120 130 140 150
PHPLQFLREA NAGNLKPLFE FVREALKPVD SGEARWTYPV LLVDDLSVLL
160 170 180 190 200
SLGMGAVAVL DFIHYCRATV CWELKGNMVV LVHDSGDAED EENDILLNGL
210 220 230 240 250
SHQSHLILRA EGLATGFCRD VHGQLRILWR RPSQPAVHRD QSFTYQYKIQ
260
DKSVSFFAKG MSPAVL
Length:266
Mass (Da):29,793
Last modified:October 31, 2006 - v1
Checksum:i49D96C1484446FB0
GO
Isoform 2 (identifier: Q0PNE2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-250: LRILWRRPSQPAVHRDQSFTYQYKIQ → VCRGLLGNGLLARVPVILDYIGESQA
     251-266: Missing.

Note: No experimental confirmation available.

Show »
Length:250
Mass (Da):27,567
Checksum:i8F498821A14458CE
GO

Sequence cautioni

The sequence AAH00623.1 differs from that shown. Reason: Frameshift at position 256.
The sequence AAH14204.1 differs from that shown. Reason: Frameshift at position 256.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei225 – 25026LRILW…QYKIQ → VCRGLLGNGLLARVPVILDY IGESQA in isoform 2. 1 PublicationVSP_022721Add
BLAST
Alternative sequencei251 – 26616Missing in isoform 2. 1 PublicationVSP_022722Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ787088 mRNA. Translation: ABG79574.1.
AK000218 mRNA. Translation: BAA91017.1.
BC000623 mRNA. Translation: AAH00623.1. Frameshift.
BC014204 mRNA. Translation: AAH14204.1. Frameshift.
CCDSiCCDS43082.1. [Q0PNE2-1]
RefSeqiNP_001026873.2. NM_001031703.2. [Q0PNE2-1]
UniGeneiHs.311100.

Genome annotation databases

EnsembliENST00000296149; ENSP00000296149; ENSG00000163832. [Q0PNE2-1]
GeneIDi54859.
KEGGihsa:54859.
UCSCiuc003crk.3. human. [Q0PNE2-1]
uc003crl.1. human. [Q0PNE2-2]

Polymorphism databases

DMDMi121940398.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ787088 mRNA. Translation: ABG79574.1 .
AK000218 mRNA. Translation: BAA91017.1 .
BC000623 mRNA. Translation: AAH00623.1 . Frameshift.
BC014204 mRNA. Translation: AAH14204.1 . Frameshift.
CCDSi CCDS43082.1. [Q0PNE2-1 ]
RefSeqi NP_001026873.2. NM_001031703.2. [Q0PNE2-1 ]
UniGenei Hs.311100.

3D structure databases

ProteinModelPortali Q0PNE2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120209. 13 interactions.
IntActi Q0PNE2. 3 interactions.

PTM databases

PhosphoSitei Q0PNE2.

Polymorphism databases

DMDMi 121940398.

Proteomic databases

MaxQBi Q0PNE2.
PaxDbi Q0PNE2.
PRIDEi Q0PNE2.

Protocols and materials databases

DNASUi 54859.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296149 ; ENSP00000296149 ; ENSG00000163832 . [Q0PNE2-1 ]
GeneIDi 54859.
KEGGi hsa:54859.
UCSCi uc003crk.3. human. [Q0PNE2-1 ]
uc003crl.1. human. [Q0PNE2-2 ]

Organism-specific databases

CTDi 54859.
GeneCardsi GC03M047537.
HGNCi HGNC:25976. ELP6.
HPAi HPA046358.
MIMi 615020. gene.
neXtProti NX_Q0PNE2.
PharmGKBi PA164717260.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG258199.
GeneTreei ENSGT00390000011734.
HOGENOMi HOG000068138.
HOVERGENi HBG103008.
InParanoidi Q0PNE2.
OMAi SFFAKGM.
OrthoDBi EOG7327Q1.
PhylomeDBi Q0PNE2.
TreeFami TF331346.

Enzyme and pathway databases

Reactomei REACT_172610. HATs acetylate histones.

Miscellaneous databases

ChiTaRSi C3orf75. human.
GenomeRNAii 54859.
NextBioi 57736.
PROi Q0PNE2.
SOURCEi Search...

Gene expression databases

Bgeei Q0PNE2.
ExpressionAtlasi Q0PNE2. baseline and differential.
Genevestigatori Q0PNE2.

Family and domain databases

InterProi IPR018627. UPF0405.
[Graphical view ]
Pfami PF09807. DUF2348. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Screening the cirrhosis related genes by microarray."
    Liu X., Wei H., Chen J.
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon mucosa.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  4. "DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator."
    Close P., Gillard M., Ladang A., Jiang Z., Papuga J., Hawkes N., Nguyen L., Chapelle J.P., Bouillenne F., Svejstrup J., Fillet M., Chariot A.
    J. Biol. Chem. 287:32535-32545(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RNA POLYMERASE II ELONGATOR COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiELP6_HUMAN
AccessioniPrimary (citable) accession number: Q0PNE2
Secondary accession number(s): Q9BW57, Q9NXJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 31, 2006
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3