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Protein

Elongator complex protein 6

Gene

ELP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration.

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 6
Alternative name(s):
Angiotonin-transactivated protein 1
Protein TMEM103
Gene namesi
Name:ELP6
Synonyms:ATP1, C3orf75, TMEM103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163832.15
HGNCiHGNC:25976 ELP6
MIMi615020 gene
neXtProtiNX_Q0PNE2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi54859
OpenTargetsiENSG00000163832
PharmGKBiPA164717260

Polymorphism and mutation databases

BioMutaiELP6
DMDMi121940398

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743601 – 266Elongator complex protein 6Add BLAST266

Proteomic databases

EPDiQ0PNE2
MaxQBiQ0PNE2
PaxDbiQ0PNE2
PeptideAtlasiQ0PNE2
PRIDEiQ0PNE2

PTM databases

iPTMnetiQ0PNE2
PhosphoSitePlusiQ0PNE2

Expressioni

Gene expression databases

BgeeiENSG00000163832
ExpressionAtlasiQ0PNE2 baseline and differential
GenevisibleiQ0PNE2 HS

Organism-specific databases

HPAiHPA046358
HPA064545

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator), which consists of ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6.1 Publication

Protein-protein interaction databases

BioGridi120209, 30 interactors
CORUMiQ0PNE2
IntActiQ0PNE2, 3 interactors
STRINGi9606.ENSP00000296149

Structurei

3D structure databases

ProteinModelPortaliQ0PNE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELP6 family.Curated

Phylogenomic databases

eggNOGiKOG4723 Eukaryota
ENOG4111K40 LUCA
GeneTreeiENSGT00390000011734
HOGENOMiHOG000068138
HOVERGENiHBG103008
InParanoidiQ0PNE2
OMAiKGMSPAV
OrthoDBiEOG091G0L48
PhylomeDBiQ0PNE2
TreeFamiTF331346

Family and domain databases

InterProiView protein in InterPro
IPR018627 ELP6
PfamiView protein in Pfam
PF09807 ELP6, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0PNE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFVELNNLLN TTPDRAEQGK LTLLCDAKTD GSFLVHHFLS FYLKANCKVC
60 70 80 90 100
FVALIQSFSH YSIVGQKLGV SLTMARERGQ LVFLEGLKSA VDVVFQAQKE
110 120 130 140 150
PHPLQFLREA NAGNLKPLFE FVREALKPVD SGEARWTYPV LLVDDLSVLL
160 170 180 190 200
SLGMGAVAVL DFIHYCRATV CWELKGNMVV LVHDSGDAED EENDILLNGL
210 220 230 240 250
SHQSHLILRA EGLATGFCRD VHGQLRILWR RPSQPAVHRD QSFTYQYKIQ
260
DKSVSFFAKG MSPAVL
Length:266
Mass (Da):29,793
Last modified:October 31, 2006 - v1
Checksum:i49D96C1484446FB0
GO
Isoform 2 (identifier: Q0PNE2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-250: LRILWRRPSQPAVHRDQSFTYQYKIQ → VCRGLLGNGLLARVPVILDYIGESQA
     251-266: Missing.

Note: No experimental confirmation available.
Show »
Length:250
Mass (Da):27,567
Checksum:i8F498821A14458CE
GO

Sequence cautioni

The sequence AAH00623 differs from that shown. Reason: Frameshift at position 256.Curated
The sequence AAH14204 differs from that shown. Reason: Frameshift at position 256.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022721225 – 250LRILW…QYKIQ → VCRGLLGNGLLARVPVILDY IGESQA in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_022722251 – 266Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ787088 mRNA Translation: ABG79574.1
AK000218 mRNA Translation: BAA91017.1
BC000623 mRNA Translation: AAH00623.1 Frameshift.
BC014204 mRNA Translation: AAH14204.1 Frameshift.
CCDSiCCDS43082.1 [Q0PNE2-1]
RefSeqiNP_001026873.2, NM_001031703.2 [Q0PNE2-1]
UniGeneiHs.311100

Genome annotation databases

EnsembliENST00000296149; ENSP00000296149; ENSG00000163832 [Q0PNE2-1]
GeneIDi54859
KEGGihsa:54859
UCSCiuc003crk.4 human [Q0PNE2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiELP6_HUMAN
AccessioniPrimary (citable) accession number: Q0PNE2
Secondary accession number(s): Q9BW57, Q9NXJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 31, 2006
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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