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Protein

Anthrax toxin receptor 1

Gene

Antxr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50Divalent metal cationBy similarity1
Metal bindingi52Divalent metal cationBy similarity1
Metal bindingi116Divalent metal cationBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anthrax toxin receptor 1
Gene namesi
Name:Antxr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1307144. Antxr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 319ExtracellularSequence analysisAdd BLAST294
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 562CytoplasmicSequence analysisAdd BLAST222

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000037988026 – 562Anthrax toxin receptor 1Add BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 218By similarity
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1
Glycosylationi260N-linked (GlcNAc...)Sequence analysis1
Modified residuei360PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ0PMD2.
PRIDEiQ0PMD2.

PTM databases

iPTMnetiQ0PMD2.
PhosphoSitePlusiQ0PMD2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008678.

Interactioni

Subunit structurei

Interacts with gelatin and type 1 collagen. Interacts with the actin cytoskeleton. Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011675.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 213VWFAPROSITE-ProRule annotationAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 158Interaction with PABy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi358 – 366Asp/Glu-rich (highly acidic)9
Compositional biasi501 – 562Pro-richAdd BLAST62

Domaini

Binding to PA occurs through the VWA domain.By similarity

Sequence similaritiesi

Belongs to the ATR family.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK1W. Eukaryota.
ENOG410YC57. LUCA.
HOGENOMiHOG000264249.
InParanoidiQ0PMD2.
PhylomeDBiQ0PMD2.
TreeFamiTF328943.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR017360. Anthrax_toxin_rcpt.
IPR008399. Anthrax_toxin_rcpt_C.
IPR008400. Anthrax_toxin_rcpt_extracel.
IPR002035. VWF_A.
[Graphical view]
PfamiPF05586. Ant_C. 1 hit.
PF05587. Anth_Ig. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PIRSFiPIRSF038023. Anthrax_toxin_receptor_2. 1 hit.
ProDomiPD377005. Anthrax_toxin_rcpt_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0PMD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRAGRLGTG LRGLCVAALV LVCAGQGGRR EDGGPACYGG FDLYFILDKS
60 70 80 90 100
GSVLHHWNEI YYFVEQLAHR FISPQLRMSF IVFSTRGTTL MKLTEDREQI
110 120 130 140 150
RQGLEELQKV LPGGDTYMHE GFERASEQIY YENSQGYRTA SVIIALTDGE
160 170 180 190 200
LHEDLFFYSE REANRSRDLG AIVYCVGVKD FNETQLARIA DSKDHVFPVN
210 220 230 240 250
DGFQALQGII HSILKKSCIE ILAAEPSTIC AGESFQVVVR GNGFRHARNV
260 270 280 290 300
DRVLCSFKIN DSVTLNEKPF AVEDTYLLCP APILKEVGMK AALQVSMNDG
310 320 330 340 350
LSFISSSVII TTTHCSDGSI LAIALLILFL LLALALLWWF WPLCCTVIIK
360 370 380 390 400
EVPPPPVEES EEEDDDGLPK KKWPTVDASY YGGRGVGGIK RMEVRWGEKG
410 420 430 440 450
STEEGAKLEK AKNARVKMPE QEYEFPEPRN LNNNMRRPSS PRKWYSPIKG
460 470 480 490 500
KLDALWVLLR KGYDRVSVMR PQPGDTGRCI NFTRVKNSQP AKYPLNNSYH
510 520 530 540 550
SSSPPPAPIY TPPPPAPHCP PPAPSAPTPP IPSPPSTLPP PPQAPPPNRA
560
PPPSRPPPRP SV
Length:562
Mass (Da):62,319
Last modified:July 28, 2009 - v2
Checksum:i35E9ADB6C92D49F5
GO

Sequence cautioni

The sequence AAI31854 differs from that shown. Reason: Erroneous initiation.Curated
The sequence ABH03702 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ789143 mRNA. Translation: ABH03702.1. Different initiation.
BC131853 mRNA. Translation: AAI31854.1. Different initiation.
RefSeqiNP_001037714.1. NM_001044249.2.
UniGeneiRn.41192.

Genome annotation databases

GeneIDi362393.
KEGGirno:362393.
UCSCiRGD:1307144. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ789143 mRNA. Translation: ABH03702.1. Different initiation.
BC131853 mRNA. Translation: AAI31854.1. Different initiation.
RefSeqiNP_001037714.1. NM_001044249.2.
UniGeneiRn.41192.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011675.

PTM databases

iPTMnetiQ0PMD2.
PhosphoSitePlusiQ0PMD2.

Proteomic databases

PaxDbiQ0PMD2.
PRIDEiQ0PMD2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi362393.
KEGGirno:362393.
UCSCiRGD:1307144. rat.

Organism-specific databases

CTDi84168.
RGDi1307144. Antxr1.

Phylogenomic databases

eggNOGiENOG410IK1W. Eukaryota.
ENOG410YC57. LUCA.
HOGENOMiHOG000264249.
InParanoidiQ0PMD2.
PhylomeDBiQ0PMD2.
TreeFamiTF328943.

Miscellaneous databases

PROiQ0PMD2.

Gene expression databases

BgeeiENSRNOG00000008678.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR017360. Anthrax_toxin_rcpt.
IPR008399. Anthrax_toxin_rcpt_C.
IPR008400. Anthrax_toxin_rcpt_extracel.
IPR002035. VWF_A.
[Graphical view]
PfamiPF05586. Ant_C. 1 hit.
PF05587. Anth_Ig. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PIRSFiPIRSF038023. Anthrax_toxin_receptor_2. 1 hit.
ProDomiPD377005. Anthrax_toxin_rcpt_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANTR1_RAT
AccessioniPrimary (citable) accession number: Q0PMD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 28, 2009
Last modified: November 2, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.