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Protein
Submitted name:

Mutant TLR6

Gene

Tlr6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorSAAS annotation
Biological processImmunity, Innate immunitySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Mutant TLR6Imported
Gene namesi
Name:Tlr6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1341296. Tlr6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 39HelicalSequence analysisAdd BLAST20
Transmembranei596 – 620HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ0PM14.

Structurei

3D structure databases

ProteinModelPortaliQ0PM14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini651 – 795TIRInterPro annotationAdd BLAST145

Sequence similaritiesi

Belongs to the Toll-like receptor family.SAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000008676.
HOVERGENiHBG023180.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 3 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032675. LRR_dom_sf.
IPR000157. TIR_dom.
IPR027187. TLR6.
IPR035897. Toll_tir_struct_dom_sf.
PANTHERiPTHR24365:SF422. PTHR24365:SF422. 1 hit.
PfamiView protein in Pfam
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0PM14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKSLWDSLC NMSQDRKPIV GSFHFVCALA LIVGSMTPFS NELESMVDYS
60 70 80 90 100
NRNLTHVPKD LPPRTKALSL SQNSISELRM PDISFLSELR VLRLSHNRIR
110 120 130 140 150
SLDFHVFLFN QDLEYLDVSH NRLQNISCCP MASLRHLDLS FNDFDVLPVC
160 170 180 190 200
KEFGNLTKLT FLGLSAAKFR QLDLLPVAHL HLSCILLDLV SYHIKGGETE
210 220 230 240 250
SLQIPNTTVL HLVFHPNSLF SVQVNMSVNA LGHLQLSNIK LNDENCQRLM
260 270 280 290 300
TFLSELTRGP TLLNVTLQHI ETTWKCSVKL FQFFWPRPVE YLNIYNLTIT
310 320 330 340 350
ERIDREEFTY SETALKSLMI EHVKNQAFLF SKEALYSVFA EMNIKMLSIS
360 370 380 390 400
DTPFIHMVCP PSPSSFTFLN FTQNVFTDSV FQGCSTLKRL QTLILQRNGL
410 420 430 440 450
KNFFKVALMT KNMSSLETLD VSLNSLNSHA YDRTCAWAES ILVLNLSSNM
460 470 480 490 500
LTGSVFRCLP PKVKVLDLHN NRIMSIPKDV THLQALQELN VASNSLTDLP
510 520 530 540 550
GCGAFSSLSV LVIDHNSVSH PSEDFFQSCQ NIRSLTAGNN PFQCTCELRD
560 570 580 590 600
FVKNIGWVAR EVVEGWPDSY RCDYPESSKG TALRDFHMSP LSCDTVLLTI
610 620 630 640 650
TIGATMLVLA VTGAFLCLYF DLPWYVRMLC QWTQTRHRAR HIPLEELQRN
660 670 680 690 700
LQFHAFVSYS EHDSAWVKNE LLPNLEKDDI RVCLHERNFV PGKSIVENII
710 720 730 740 750
NFIEKSYKAI FVLSPHFIQS EWCHYELYFA HHNLFHEGSD NLILILLEPI
760 770 780 790 800
LQNNIPSRYH KLRALMAQRT YLEWPTEKGK RGLFWANLRA SFIMKLALVN

EDDVKT
Length:806
Mass (Da):92,380
Last modified:September 5, 2006 - v1
Checksum:i03748BAF1CBCB2B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ790887 mRNA. Translation: ABG78745.1.
UniGeneiMm.42146.

Similar proteinsi

Entry informationi

Entry nameiQ0PM14_MOUSE
AccessioniPrimary (citable) accession number: Q0PM14
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: November 22, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)