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Protein

Caspase

Gene

casp2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei245UniRule annotation1
Active sitei288UniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • intrinsic apoptotic signaling pathway in response to DNA damage Source: ZFIN
  • positive regulation of apoptotic process Source: ZFIN
  • regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-6803207. TP53 Regulates Transcription of Caspase Activators and Caspases.

Protein family/group databases

MEROPSiC14.006.

Names & Taxonomyi

Protein namesi
Recommended name:
CaspaseUniRule annotation
Gene namesi
Name:casp2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-030825-3. casp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiE7F2V8.

Expressioni

Gene expression databases

BgeeiENSDARG00000062052.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000105801.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 97CARDInterPro annotationAdd BLAST91
Domaini165 – 292CASPASE_P20InterPro annotationAdd BLAST128
Domaini336 – 429CASPASE_P10InterPro annotationAdd BLAST94

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.
HOGENOMiHOG000290714.
HOVERGENiHBG103962.
InParanoidiE7F2V8.
KOiK02186.
OMAiPNLQNKP.
OrthoDBiEOG091G05YD.

Family and domain databases

CDDicd00032. CASc. 1 hit.
Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
IPR017350. Pept_C14A_CASP1-typ.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0PKX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGECGMTKW ERLALRRNSV KMLQDLVVDD LLIQCLQQDG ILTDSMAESI
60 70 80 90 100
MAKPTSQGRS HQLLFLLPKR GPRAFSTFCS ALKETEQHHL CKLLMDFTEK
110 120 130 140 150
DKCFSEPSLS LPTQECVTPA KRPRTHESME MCLDADSPVT TAVLPCTPEF
160 170 180 190 200
YQSHRPQAYP MRSCPRGLAL VLSNVRFDSA NTDLDIRRGG EVDEETLRRL
210 220 230 240 250
FTELDFKVSL HRDLTAEAMR RCLEQFAQQQ EHAAYDCAVV CLLSHGVEGS
260 270 280 290 300
VYGTDGQLLE LDWVFEVFDN ARCPLLQNKP KMFFIQACRG EEMDNGVDQL
310 320 330 340 350
DGQERTQSPG CEQRDAGREG ERDNREKKEE KERERLRVKL PQRSDMICGF
360 370 380 390 400
ATLKGTAAMR NTKKGSWFIQ ELNTAIRQRA NNTHLSDILV QVNGQIKSRE
410 420 430
GYAPGSAHHR CKEMSEFTSS LCKDLYLFPK YYPSN
Length:435
Mass (Da):49,577
Last modified:September 5, 2006 - v1
Checksum:i49C94030D66C17CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR855317 Genomic DNA. No translation available.
FP015958 Genomic DNA. No translation available.
BC163115 mRNA. Translation: AAI63115.1.
BC163139 mRNA. Translation: AAI63139.1.
DQ812119 mRNA. Translation: ABG91569.1.
RefSeqiNP_001036160.1. NM_001042695.1.
XP_009290451.1. XM_009292176.2.
UniGeneiDr.162020.

Genome annotation databases

EnsembliENSDART00000122212; ENSDARP00000105801; ENSDARG00000062052.
GeneIDi373118.
KEGGidre:373118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR855317 Genomic DNA. No translation available.
FP015958 Genomic DNA. No translation available.
BC163115 mRNA. Translation: AAI63115.1.
BC163139 mRNA. Translation: AAI63139.1.
DQ812119 mRNA. Translation: ABG91569.1.
RefSeqiNP_001036160.1. NM_001042695.1.
XP_009290451.1. XM_009292176.2.
UniGeneiDr.162020.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000105801.

Protein family/group databases

MEROPSiC14.006.

Proteomic databases

PaxDbiE7F2V8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000122212; ENSDARP00000105801; ENSDARG00000062052.
GeneIDi373118.
KEGGidre:373118.

Organism-specific databases

CTDi835.
ZFINiZDB-GENE-030825-3. casp2.

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.
HOGENOMiHOG000290714.
HOVERGENiHBG103962.
InParanoidiE7F2V8.
KOiK02186.
OMAiPNLQNKP.
OrthoDBiEOG091G05YD.

Enzyme and pathway databases

ReactomeiR-DRE-6803207. TP53 Regulates Transcription of Caspase Activators and Caspases.

Gene expression databases

BgeeiENSDARG00000062052.

Family and domain databases

CDDicd00032. CASc. 1 hit.
Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
IPR017350. Pept_C14A_CASP1-typ.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ0PKX3_DANRE
AccessioniPrimary (citable) accession number: Q0PKX3
Secondary accession number(s): E7F2V8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.