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Q0PHY0

- ACDH_SPIAU

UniProt

Q0PHY0 - ACDH_SPIAU

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Protein

Acetaldehyde dehydrogenase

Gene
N/A
Organism
Spirochaeta aurantia
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331Acyl-thioester intermediateUniRule annotation
Binding sitei275 – 2751NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 214NADUniRule annotation
Nucleotide bindingi165 – 1739NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
OrganismiSpirochaeta aurantia
Taxonomic identifieri147 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Acetaldehyde dehydrogenasePRO_0000387746Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ0PHY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0PHY0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRFPLAAKP LQVAILGTGN IGTDLLLKIQ RSQLLKCVAF VGRSSQSSGM
60 70 80 90 100
VKARSLGVPC SDLSIEYFRQ NGEKIDLVFD ATSAKDHLVH APILRELGIR
110 120 130 140 150
VIDLTPAKVG KMCIPAVHRS SLLNEWNLNM VTCGGQASSP LAWAIGQTQG
160 170 180 190 200
SIEYLEVVSS IASKSAGPAT RLNLDEYIHT TEKALAELSG AKNTKAILVL
210 220 230 240 250
NPAEPCIDMQ TTVFAKVDSP DLLKLQKLLS EVIPRTQAYV PGYQVALGPI
260 270 280 290
VDNGRISIMV RVRGVGDYLP EYAGNLDIIN CAAIAMAEEY AKAAHEQ
Length:297
Mass (Da):31,923
Last modified:November 3, 2009 - v2
Checksum:i25B17B8F551167E2
GO

Sequence cautioni

The sequence ABH03011.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ832182 Genomic DNA. Translation: ABH03011.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ832182 Genomic DNA. Translation: ABH03011.1 . Different initiation.

3D structure databases

ProteinModelPortali Q0PHY0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "LGLA, the large glycolipid of Spirochaeta aurantia."
    Paul C.J., Vinogradov E., Tapping R.I., Perry M.B., Moyles D., Kropinski A.M.
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiACDH_SPIAU
AccessioniPrimary (citable) accession number: Q0PHY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: October 1, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3