Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q0PHY0 (ACDH_SPIAU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
OrganismSpirochaeta aurantia
Taxonomic identifier147 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Sequence caution

The sequence ABH03011.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387746

Regions

Nucleotide binding18 – 214NAD By similarity
Nucleotide binding165 – 1739NAD By similarity

Sites

Active site1331Acyl-thioester intermediate By similarity
Binding site2751NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0PHY0 [UniParc].

Last modified November 3, 2009. Version 2.
Checksum: 25B17B8F551167E2

FASTA29731,923
        10         20         30         40         50         60 
MGRFPLAAKP LQVAILGTGN IGTDLLLKIQ RSQLLKCVAF VGRSSQSSGM VKARSLGVPC 

        70         80         90        100        110        120 
SDLSIEYFRQ NGEKIDLVFD ATSAKDHLVH APILRELGIR VIDLTPAKVG KMCIPAVHRS 

       130        140        150        160        170        180 
SLLNEWNLNM VTCGGQASSP LAWAIGQTQG SIEYLEVVSS IASKSAGPAT RLNLDEYIHT 

       190        200        210        220        230        240 
TEKALAELSG AKNTKAILVL NPAEPCIDMQ TTVFAKVDSP DLLKLQKLLS EVIPRTQAYV 

       250        260        270        280        290 
PGYQVALGPI VDNGRISIMV RVRGVGDYLP EYAGNLDIIN CAAIAMAEEY AKAAHEQ 

« Hide

References

[1]"LGLA, the large glycolipid of Spirochaeta aurantia."
Paul C.J., Vinogradov E., Tapping R.I., Perry M.B., Moyles D., Kropinski A.M.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ832182 Genomic DNA. Translation: ABH03011.1. Different initiation.

3D structure databases

ProteinModelPortalQ0PHY0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_SPIAU
AccessionPrimary (citable) accession number: Q0PHY0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: February 19, 2014
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families