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Q0PHY0

- ACDH_SPIAU

UniProt

Q0PHY0 - ACDH_SPIAU

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Protein
Acetaldehyde dehydrogenase
Gene
N/A
Organism
Spirochaeta aurantia
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331Acyl-thioester intermediate By similarity
Binding sitei275 – 2751NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 214NAD By similarity
Nucleotide bindingi165 – 1739NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
OrganismiSpirochaeta aurantia
Taxonomic identifieri147 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Acetaldehyde dehydrogenaseUniRule annotation
PRO_0000387746Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ0PHY0.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0PHY0-1 [UniParc]FASTAAdd to Basket

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MGRFPLAAKP LQVAILGTGN IGTDLLLKIQ RSQLLKCVAF VGRSSQSSGM    50
VKARSLGVPC SDLSIEYFRQ NGEKIDLVFD ATSAKDHLVH APILRELGIR 100
VIDLTPAKVG KMCIPAVHRS SLLNEWNLNM VTCGGQASSP LAWAIGQTQG 150
SIEYLEVVSS IASKSAGPAT RLNLDEYIHT TEKALAELSG AKNTKAILVL 200
NPAEPCIDMQ TTVFAKVDSP DLLKLQKLLS EVIPRTQAYV PGYQVALGPI 250
VDNGRISIMV RVRGVGDYLP EYAGNLDIIN CAAIAMAEEY AKAAHEQ 297
Length:297
Mass (Da):31,923
Last modified:November 3, 2009 - v2
Checksum:i25B17B8F551167E2
GO

Sequence cautioni

The sequence ABH03011.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ832182 Genomic DNA. Translation: ABH03011.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ832182 Genomic DNA. Translation: ABH03011.1 . Different initiation.

3D structure databases

ProteinModelPortali Q0PHY0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "LGLA, the large glycolipid of Spirochaeta aurantia."
    Paul C.J., Vinogradov E., Tapping R.I., Perry M.B., Moyles D., Kropinski A.M.
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiACDH_SPIAU
AccessioniPrimary (citable) accession number: Q0PHY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: February 19, 2014
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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