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Q0PCR6 (Q0PCR6_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Cacna1c MGI 103013
Synonyms:CaV1.2-a EMBL BAF03165.1
OrganismMus musculus (Mouse) EMBL BAF03165.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2169 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Ontologies

Keywords
   Biological processCalcium transport
Ion transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS027359
   LigandCalcium
   Molecular functionCalcium channel RuleBase RU003808
Ion channel
Voltage-gated channel RuleBase RU003808 SAAS SAAS027359
Gene Ontology (GO)
   Biological_processadult walking behavior

Inferred from genetic interaction PubMed 9882694. Source: MGI

calcium ion import

Inferred from Biological aspect of Ancestor. Source: RefGenome

calcium ion transport

Inferred from direct assay PubMed 7635187. Source: MGI

calcium ion-dependent exocytosis

Inferred from mutant phenotype PubMed 12881419. Source: MGI

cellular calcium ion homeostasis

Inferred from mutant phenotype PubMed 15132976. Source: MGI

glucose homeostasis

Inferred from mutant phenotype PubMed 12881419. Source: MGI

growth hormone secretion

Inferred from direct assay PubMed 1385406. Source: MGI

insulin secretion

Inferred from mutant phenotype PubMed 12881419. Source: MGI

membrane depolarization during action potential

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of blood pressure

Inferred from mutant phenotype PubMed 14609949. Source: MGI

regulation of organ growth

Inferred from mutant phenotype PubMed 15132976. Source: MGI

regulation of vasoconstriction

Inferred from mutant phenotype PubMed 14609949. Source: MGI

smooth muscle contraction

Inferred from mutant phenotype PubMed 16636102. Source: MGI

smooth muscle contraction involved in micturition

Inferred from mutant phenotype PubMed 15132976. Source: MGI

synaptic transmission

Inferred from mutant phenotype PubMed 16251435. Source: MGI

visual learning

Inferred from mutant phenotype PubMed 16251435. Source: MGI

   Cellular_componentT-tubule

Traceable author statement PubMed 11784029. Source: MGI

Z disc

Inferred from direct assay PubMed 19383796. Source: MGI

caveolar macromolecular signaling complex

Inferred from direct assay PubMed 16648270. Source: MGI

dendritic shaft

Inferred from direct assay PubMed 15090038. Source: MGI

membrane

Inferred from direct assay PubMed 15132976. Source: MGI

neuronal cell body

Inferred from direct assay PubMed 15090038. Source: MGI

plasma membrane

Inferred from direct assay PubMed 15090038PubMed 7598723. Source: MGI

voltage-gated calcium channel complex

Traceable author statement PubMed 11296258. Source: MGI

   Molecular_functionhigh voltage-gated calcium channel activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein binding

Inferred from physical interaction Ref.1. Source: MGI

voltage-gated calcium channel activity

Inferred from direct assay PubMed 1385406PubMed 16267232PubMed 7635187PubMed 7814415. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q0PCR6 [UniParc].

Last modified September 19, 2006. Version 1.
Checksum: 39764022409F63E2

FASTA2,169243,370
        10         20         30         40         50         60 
MIRAFVQPST PPYQPLSSHS SEETERKFKG KVVHEAQLNC FYISPGGSNY GSPRPAHANM 

        70         80         90        100        110        120 
NANAAAGLAP EHIPTPGAAL SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK 

       130        140        150        160        170        180 
KQGGTTATRP PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED 

       190        200        210        220        230        240 
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF IIVVVGLFSA 

       250        260        270        280        290        300 
ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG VPSLQVVLNS IIKAMVPLLH 

       310        320        330        340        350        360 
IALLVLFVII IYAIIGLELF MGKMHKTCYN QEGIIDVPAE EDPSPCALET GHGRQCQNGT 

       370        380        390        400        410        420 
VCKPGWDGPK HGITNFDNFA FAMLTVFQCI TMEGWTDVLY WMQDAMGYEL PWVYFVSLVI 

       430        440        450        460        470        480 
FGSFFVLNLV LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE 

       490        500        510        520        530        540 
NEDEGMDEDK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS KFSRYWRRWN 

       550        560        570        580        590        600 
RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPH WLTEVQDTAN KALLALFTAE 

       610        620        630        640        650        660 
MLLKMYSLGL QAYFVSLFNR FDCFIVCGGI LETILVETKI MSPLGISVLR CVRLLRIFKI 

       670        680        690        700        710        720 
TRYWNSLSNL VASLLNSVRS IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD 

       730        740        750        760        770        780 
NFPQSLLTVF QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA 

       790        800        810        820        830        840 
IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEV MEKPAVEESK EEKIELKSIT 

       850        860        870        880        890        900 
ADGESPPTTK INMDDLQPSE NEDKSPHSNP DTAGEEDEEE PEMPVGPRPR PLSELHLKEK 

       910        920        930        940        950        960 
AVPMPEASAF FIFSPNNRFR LQCHRIVNDT IFTNLILFFI LLSSISLAAE DPVQHTSFRN 

       970        980        990       1000       1010       1020 
HILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA 

      1030       1040       1050       1060       1070       1080 
INVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL 

      1090       1100       1110       1120       1130       1140 
FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN VLAAMMALFT 

      1150       1160       1170       1180       1190       1200 
VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ 

      1210       1220       1230       1240       1250       1260 
EQGEQEYKNC ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL 

      1270       1280       1290       1300       1310       1320 
LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL IAFKPKGYFS DPWNVFDFLI 

      1330       1340       1350       1360       1370       1380 
VIGSIIDVIL SETNPAEHTQ CSPSMSAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL 

      1390       1400       1410       1420       1430       1440 
WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ TFPQAVLLLF 

      1450       1460       1470       1480       1490       1500 
RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS FAVFYFISFY MLCAFLIINL 

      1510       1520       1530       1540       1550       1560 
FVAVIMDNFD YLTRDWSILG PHHLDEFKRI WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF 

      1570       1580       1590       1600       1610       1620 
GKLCPHRVAC KRLVSMNMPL NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK 

      1630       1640       1650       1660       1670       1680 
KIWKRTSMKL LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV GKPSQRNALS 

      1690       1700       1710       1720       1730       1740 
LQAGLRTLHD IGPEIRRAIS GDLTAEEELD KAMKEAVSAA SEDDIFRRAG GLFGNHVTYY 

      1750       1760       1770       1780       1790       1800 
QSDSRGNFPQ TFATQRPLHI NKTGNNQADT ESPSHEKLVD STFTPSSYSS TGSNANINNA 

      1810       1820       1830       1840       1850       1860 
NNTALGRFPH PAGYSSTVST VEGHGPPLSP AVRVQEAAWK LSSKRCHSRE SQGATVNQEI 

      1870       1880       1890       1900       1910       1920 
FPDETRSVRM SEEAEYCSEP SLLSTDMFSY QEDEHRQLTC PEEDKREIQP SPKRSFLRSA 

      1930       1940       1950       1960       1970       1980 
SLGRRASFHL ECLKRQKDQG GDISQKTALP LHLVHHQALA VAGLSPLLQR SHSPTTFPRP 

      1990       2000       2010       2020       2030       2040 
CPTPPVTPGS RGRPLRPIPT LRLEGAESSE KLNSSFPSIH CSSWSEETTA CSGSSSMARR 

      2050       2060       2070       2080       2090       2100 
ARPVSLTVPS QAGAPGRQFH GSASSLVEAV LISEGLGQFA QDPKFIEVTT QELADACDMT 

      2110       2120       2130       2140       2150       2160 
IEEMENAADN ILSGGAQQSP NGTLLPFVNC RDPGQDRAVA PEDESCAYAL GRGRSEEALA 


DSRSYVSNL 

« Hide

References

[1]"Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit."
Murakami M., Ohba T., Takahashi Y., Watanabe H., Miyoshi I., Nakayama S., Ono K., Ito H., Iijima T.
J. Mol. Cell. Cardiol. 41:115-125(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Heart EMBL BAF03165.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB259049 mRNA. Translation: BAF03165.1.
RefSeqNP_001153005.1. NM_001159533.2.
NP_001153006.1. NM_001159534.2.
NP_001153007.1. NM_001159535.2.
NP_033911.2. NM_009781.4.
UniGeneMm.41628.
Mm.436656.

3D structure databases

ProteinModelPortalQ0PCR6.
SMRQ0PCR6. Positions 1642-1670.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ0PCR6.

Proteomic databases

PRIDEQ0PCR6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID12288.
KEGGmmu:12288.
UCSCuc009dlu.2. mouse.

Organism-specific databases

CTD775.
MGIMGI:103013. Cacna1c.

Phylogenomic databases

HOVERGENHBG050763.
InParanoidQ0PCR6.
KOK04850.

Gene expression databases

ArrayExpressQ0PCR6.
BgeeQ0PCR6.
GenevestigatorQ0PCR6.

Family and domain databases

Gene3D1.20.120.350. 4 hits.
InterProIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCACNA1C. mouse.
NextBio280766.
SOURCESearch...

Entry information

Entry nameQ0PCR6_MOUSE
AccessionPrimary (citable) accession number: Q0PCR6
Entry history
Integrated into UniProtKB/TrEMBL: September 19, 2006
Last sequence update: September 19, 2006
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)