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Q0PCR6

- Q0PCR6_MOUSE

UniProt

Q0PCR6 - Q0PCR6_MOUSE

Protein
Submitted name:

Voltage-dependent calcium channel splice variant 1.2-a

Gene

Cacna1c

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (19 Sep 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. high voltage-gated calcium channel activity Source: RefGenome
    2. protein binding Source: MGI
    3. voltage-gated calcium channel activity Source: MGI

    GO - Biological processi

    1. adult walking behavior Source: MGI
    2. calcium ion-dependent exocytosis Source: MGI
    3. calcium ion import Source: RefGenome
    4. calcium ion transport Source: MGI
    5. cellular calcium ion homeostasis Source: MGI
    6. glucose homeostasis Source: MGI
    7. growth hormone secretion Source: MGI
    8. insulin secretion Source: MGI
    9. membrane depolarization during action potential Source: RefGenome
    10. regulation of blood pressure Source: MGI
    11. regulation of organ growth Source: MGI
    12. regulation of vasoconstriction Source: MGI
    13. smooth muscle contraction Source: MGI
    14. smooth muscle contraction involved in micturition Source: MGI
    15. synaptic transmission Source: MGI
    16. visual learning Source: MGI

    Keywords - Molecular functioni

    Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Voltage-dependent calcium channel splice variant 1.2-aImported
    Gene namesi
    Name:Cacna1cImported
    Synonyms:CaV1.2-aImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:103013. Cacna1c.

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. caveolar macromolecular signaling complex Source: MGI
    2. dendritic shaft Source: MGI
    3. membrane Source: MGI
    4. neuronal cell body Source: MGI
    5. plasma membrane Source: MGI
    6. T-tubule Source: MGI
    7. voltage-gated calcium channel complex Source: MGI
    8. Z disc Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiQ0PCR6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ0PCR6.
    BgeeiQ0PCR6.
    GenevestigatoriQ0PCR6.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ0PCR6.
    SMRiQ0PCR6. Positions 1642-1670.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG050763.
    InParanoidiQ0PCR6.
    KOiK04850.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR014873. VDCC_a1su_IQ.
    IPR005451. VDCC_L_a1csu.
    IPR005446. VDCC_L_a1su.
    IPR002077. VDCCAlpha1.
    [Graphical view]
    PfamiPF08763. Ca_chan_IQ. 1 hit.
    PF00520. Ion_trans. 4 hits.
    [Graphical view]
    PRINTSiPR00167. CACHANNEL.
    PR01630. LVDCCALPHA1.
    PR01635. LVDCCALPHA1C.
    SMARTiSM01062. Ca_chan_IQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0PCR6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIRAFVQPST PPYQPLSSHS SEETERKFKG KVVHEAQLNC FYISPGGSNY     50
    GSPRPAHANM NANAAAGLAP EHIPTPGAAL SWQAAIDAAR QAKLMGSAGN 100
    ATISTVSSTQ RKRQQYGKPK KQGGTTATRP PRALLCLTLK NPIRRACISI 150
    VEWKPFEIII LLTIFANCVA LAIYIPFPED DSNATNSNLE RVEYLFLIIF 200
    TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF IIVVVGLFSA ILEQATKADG 250
    ANALGGKGAG FDVKALRAFR VLRPLRLVSG VPSLQVVLNS IIKAMVPLLH 300
    IALLVLFVII IYAIIGLELF MGKMHKTCYN QEGIIDVPAE EDPSPCALET 350
    GHGRQCQNGT VCKPGWDGPK HGITNFDNFA FAMLTVFQCI TMEGWTDVLY 400
    WMQDAMGYEL PWVYFVSLVI FGSFFVLNLV LGVLSGEFSK EREKAKARGD 450
    FQKLREKQQL EEDLKGYLDW ITQAEDIDPE NEDEGMDEDK PRNMSMPTSE 500
    TESVNTENVA GGDIEGENCG ARLAHRISKS KFSRYWRRWN RFCRRKCRAA 550
    VKSNVFYWLV IFLVFLNTLT IASEHYNQPH WLTEVQDTAN KALLALFTAE 600
    MLLKMYSLGL QAYFVSLFNR FDCFIVCGGI LETILVETKI MSPLGISVLR 650
    CVRLLRIFKI TRYWNSLSNL VASLLNSVRS IASLLLLLFL FIIIFSLLGM 700
    QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF QILTGEDWNS VMYDGIMAYG 750
    GPSFPGMLVC IYFIILFICG NYILLNVFLA IAVDNLADAE SLTSAQKEEE 800
    EEKERKKLAR TASPEKKQEV MEKPAVEESK EEKIELKSIT ADGESPPTTK 850
    INMDDLQPSE NEDKSPHSNP DTAGEEDEEE PEMPVGPRPR PLSELHLKEK 900
    AVPMPEASAF FIFSPNNRFR LQCHRIVNDT IFTNLILFFI LLSSISLAAE 950
    DPVQHTSFRN HILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN 1000
    ILDLLVVSVS LISFGIQSSA INVVKILRVL RVLRPLRAIN RAKGLKHVVQ 1050
    CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL FKGKLYTCSD SSKQTEAECK 1100
    GNYITYKDGE VDHPIIQPRS WENSKFDFDN VLAAMMALFT VSTFEGWPEL 1150
    LYRSIDSHTE DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ 1200
    EQGEQEYKNC ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY 1250
    FEYLMFVLIL LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL 1300
    IAFKPKGYFS DPWNVFDFLI VIGSIIDVIL SETNPAEHTQ CSPSMSAEEN 1350
    SRISITFFRL FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIVML 1400
    FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ TFPQAVLLLF RCATGEAWQD 1450
    IMLACMPGKK CAPESEPSNS TEGETPCGSS FAVFYFISFY MLCAFLIINL 1500
    FVAVIMDNFD YLTRDWSILG PHHLDEFKRI WAEYDPEAKG RIKHLDVVTL 1550
    LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL NSDGTVMFNA TLFALVRTAL 1600
    RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL LDQVVPPAGD DEVTVGKFYA 1650
    TFLIQEYFRK FKKRKEQGLV GKPSQRNALS LQAGLRTLHD IGPEIRRAIS 1700
    GDLTAEEELD KAMKEAVSAA SEDDIFRRAG GLFGNHVTYY QSDSRGNFPQ 1750
    TFATQRPLHI NKTGNNQADT ESPSHEKLVD STFTPSSYSS TGSNANINNA 1800
    NNTALGRFPH PAGYSSTVST VEGHGPPLSP AVRVQEAAWK LSSKRCHSRE 1850
    SQGATVNQEI FPDETRSVRM SEEAEYCSEP SLLSTDMFSY QEDEHRQLTC 1900
    PEEDKREIQP SPKRSFLRSA SLGRRASFHL ECLKRQKDQG GDISQKTALP 1950
    LHLVHHQALA VAGLSPLLQR SHSPTTFPRP CPTPPVTPGS RGRPLRPIPT 2000
    LRLEGAESSE KLNSSFPSIH CSSWSEETTA CSGSSSMARR ARPVSLTVPS 2050
    QAGAPGRQFH GSASSLVEAV LISEGLGQFA QDPKFIEVTT QELADACDMT 2100
    IEEMENAADN ILSGGAQQSP NGTLLPFVNC RDPGQDRAVA PEDESCAYAL 2150
    GRGRSEEALA DSRSYVSNL 2169
    Length:2,169
    Mass (Da):243,370
    Last modified:September 19, 2006 - v1
    Checksum:i39764022409F63E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB259049 mRNA. Translation: BAF03165.1.
    RefSeqiNP_001153005.1. NM_001159533.2.
    NP_001153006.1. NM_001159534.2.
    NP_001153007.1. NM_001159535.2.
    NP_033911.2. NM_009781.4.
    UniGeneiMm.41628.
    Mm.436656.

    Genome annotation databases

    GeneIDi12288.
    KEGGimmu:12288.
    UCSCiuc009dlu.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB259049 mRNA. Translation: BAF03165.1 .
    RefSeqi NP_001153005.1. NM_001159533.2.
    NP_001153006.1. NM_001159534.2.
    NP_001153007.1. NM_001159535.2.
    NP_033911.2. NM_009781.4.
    UniGenei Mm.41628.
    Mm.436656.

    3D structure databases

    ProteinModelPortali Q0PCR6.
    SMRi Q0PCR6. Positions 1642-1670.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q0PCR6.

    Proteomic databases

    PRIDEi Q0PCR6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 12288.
    KEGGi mmu:12288.
    UCSCi uc009dlu.2. mouse.

    Organism-specific databases

    CTDi 775.
    MGIi MGI:103013. Cacna1c.

    Phylogenomic databases

    HOVERGENi HBG050763.
    InParanoidi Q0PCR6.
    KOi K04850.

    Miscellaneous databases

    ChiTaRSi CACNA1C. mouse.
    NextBioi 280766.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q0PCR6.
    Bgeei Q0PCR6.
    Genevestigatori Q0PCR6.

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR014873. VDCC_a1su_IQ.
    IPR005451. VDCC_L_a1csu.
    IPR005446. VDCC_L_a1su.
    IPR002077. VDCCAlpha1.
    [Graphical view ]
    Pfami PF08763. Ca_chan_IQ. 1 hit.
    PF00520. Ion_trans. 4 hits.
    [Graphical view ]
    PRINTSi PR00167. CACHANNEL.
    PR01630. LVDCCALPHA1.
    PR01635. LVDCCALPHA1C.
    SMARTi SM01062. Ca_chan_IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit."
      Murakami M., Ohba T., Takahashi Y., Watanabe H., Miyoshi I., Nakayama S., Ono K., Ito H., Iijima T.
      J. Mol. Cell. Cardiol. 41:115-125(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: HeartImported.

    Entry informationi

    Entry nameiQ0PCR6_MOUSE
    AccessioniPrimary (citable) accession number: Q0PCR6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 19, 2006
    Last sequence update: September 19, 2006
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)