Q0PCR6 (Q0PCR6_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Voltage-dependent calcium channel splice variant 1.2-a EMBL BAF03165.1

Gene names

Name:	Cacna1c MGI 103013
Synonyms:	CaV1.2-a EMBL BAF03165.1

Organism

Mus musculus (Mouse) EMBL BAF03165.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2169 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification] RuleBase RU003808

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808 Ion channel Voltage-gated channel RuleBase RU003808
Gene Ontology (GO)
Biological_process	adult walking behavior Inferred from genetic interaction PubMed 9882694. Source: MGI calcium ion-dependent exocytosis Inferred from mutant phenotype PubMed 12881419. Source: MGI cellular calcium ion homeostasis Inferred from mutant phenotype PubMed 15132976. Source: MGI glucose homeostasis Inferred from mutant phenotype PubMed 12881419. Source: MGI growth hormone secretion Inferred from direct assay PubMed 1385406. Source: MGI insulin secretion Inferred from mutant phenotype PubMed 12881419. Source: MGI regulation of blood pressure Inferred from mutant phenotype PubMed 14609949. Source: MGI regulation of organ growth Inferred from mutant phenotype PubMed 15132976. Source: MGI regulation of vasoconstriction Inferred from mutant phenotype PubMed 14609949. Source: MGI smooth muscle contraction involved in micturition Inferred from mutant phenotype PubMed 15132976. Source: MGI synaptic transmission Inferred from mutant phenotype PubMed 16251435. Source: MGI visual learning Inferred from mutant phenotype PubMed 16251435. Source: MGI
Cellular_component	T-tubule Traceable author statement PubMed 11784029. Source: MGI Z disc Inferred from direct assay PubMed 19383796. Source: MGI caveolar macromolecular signaling complex Inferred from direct assay PubMed 16648270. Source: MGI dendritic shaft Inferred from direct assay PubMed 15090038. Source: MGI neuronal cell body Inferred from direct assay PubMed 15090038. Source: MGI voltage-gated calcium channel complex Traceable author statement PubMed 11296258. Source: MGI
Molecular_function	voltage-gated calcium channel activity Inferred from direct assay PubMed 1385406PubMed 16267232PubMed 7635187PubMed 7814415. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0PCR6 [UniParc]. Last modified September 19, 2006. Version 1. Checksum: 39764022409F63E2	FASTA	2,169	243,370
	10 20 30 40 50 60 MIRAFVQPST PPYQPLSSHS SEETERKFKG KVVHEAQLNC FYISPGGSNY GSPRPAHANM 70 80 90 100 110 120 NANAAAGLAP EHIPTPGAAL SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK 130 140 150 160 170 180 KQGGTTATRP PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED 190 200 210 220 230 240 DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF IIVVVGLFSA 250 260 270 280 290 300 ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG VPSLQVVLNS IIKAMVPLLH 310 320 330 340 350 360 IALLVLFVII IYAIIGLELF MGKMHKTCYN QEGIIDVPAE EDPSPCALET GHGRQCQNGT 370 380 390 400 410 420 VCKPGWDGPK HGITNFDNFA FAMLTVFQCI TMEGWTDVLY WMQDAMGYEL PWVYFVSLVI 430 440 450 460 470 480 FGSFFVLNLV LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE 490 500 510 520 530 540 NEDEGMDEDK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS KFSRYWRRWN 550 560 570 580 590 600 RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPH WLTEVQDTAN KALLALFTAE 610 620 630 640 650 660 MLLKMYSLGL QAYFVSLFNR FDCFIVCGGI LETILVETKI MSPLGISVLR CVRLLRIFKI 670 680 690 700 710 720 TRYWNSLSNL VASLLNSVRS IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD 730 740 750 760 770 780 NFPQSLLTVF QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFICG NYILLNVFLA 790 800 810 820 830 840 IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEV MEKPAVEESK EEKIELKSIT 850 860 870 880 890 900 ADGESPPTTK INMDDLQPSE NEDKSPHSNP DTAGEEDEEE PEMPVGPRPR PLSELHLKEK 910 920 930 940 950 960 AVPMPEASAF FIFSPNNRFR LQCHRIVNDT IFTNLILFFI LLSSISLAAE DPVQHTSFRN 970 980 990 1000 1010 1020 HILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA 1030 1040 1050 1060 1070 1080 INVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL 1090 1100 1110 1120 1130 1140 FKGKLYTCSD SSKQTEAECK GNYITYKDGE VDHPIIQPRS WENSKFDFDN VLAAMMALFT 1150 1160 1170 1180 1190 1200 VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ 1210 1220 1230 1240 1250 1260 EQGEQEYKNC ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL 1270 1280 1290 1300 1310 1320 LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL IAFKPKGYFS DPWNVFDFLI 1330 1340 1350 1360 1370 1380 VIGSIIDVIL SETNPAEHTQ CSPSMSAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL 1390 1400 1410 1420 1430 1440 WTFIKSFQAL PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ TFPQAVLLLF 1450 1460 1470 1480 1490 1500 RCATGEAWQD IMLACMPGKK CAPESEPSNS TEGETPCGSS FAVFYFISFY MLCAFLIINL 1510 1520 1530 1540 1550 1560 FVAVIMDNFD YLTRDWSILG PHHLDEFKRI WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF 1570 1580 1590 1600 1610 1620 GKLCPHRVAC KRLVSMNMPL NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK 1630 1640 1650 1660 1670 1680 KIWKRTSMKL LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV GKPSQRNALS 1690 1700 1710 1720 1730 1740 LQAGLRTLHD IGPEIRRAIS GDLTAEEELD KAMKEAVSAA SEDDIFRRAG GLFGNHVTYY 1750 1760 1770 1780 1790 1800 QSDSRGNFPQ TFATQRPLHI NKTGNNQADT ESPSHEKLVD STFTPSSYSS TGSNANINNA 1810 1820 1830 1840 1850 1860 NNTALGRFPH PAGYSSTVST VEGHGPPLSP AVRVQEAAWK LSSKRCHSRE SQGATVNQEI 1870 1880 1890 1900 1910 1920 FPDETRSVRM SEEAEYCSEP SLLSTDMFSY QEDEHRQLTC PEEDKREIQP SPKRSFLRSA 1930 1940 1950 1960 1970 1980 SLGRRASFHL ECLKRQKDQG GDISQKTALP LHLVHHQALA VAGLSPLLQR SHSPTTFPRP 1990 2000 2010 2020 2030 2040 CPTPPVTPGS RGRPLRPIPT LRLEGAESSE KLNSSFPSIH CSSWSEETTA CSGSSSMARR 2050 2060 2070 2080 2090 2100 ARPVSLTVPS QAGAPGRQFH GSASSLVEAV LISEGLGQFA QDPKFIEVTT QELADACDMT 2110 2120 2130 2140 2150 2160 IEEMENAADN ILSGGAQQSP NGTLLPFVNC RDPGQDRAVA PEDESCAYAL GRGRSEEALA DSRSYVSNL

References

[1]	"Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit." Murakami M., Ohba T., Takahashi Y., Watanabe H., Miyoshi I., Nakayama S., Ono K., Ito H., Iijima T. J. Mol. Cell. Cardiol. 41:115-125(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Heart EMBL BAF03165.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB259049 mRNA. Translation: BAF03165.1.
IPI	IPI00128362.
RefSeq	NP_001153005.1. NM_001159533.1. NP_001153006.1. NM_001159534.1. NP_001153007.1. NM_001159535.1. NP_033911.2. NM_009781.3.
UniGene	Mm.436656.
3D structure databases
ProteinModelPortal	Q0PCR6.
SMR	Q0PCR6. Positions 1642-1670.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0PCR6.
Proteomic databases
PRIDE	Q0PCR6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	12288.
KEGG	mmu:12288.
UCSC	uc009dlu.2. mouse.
Organism-specific databases
CTD	775.
MGI	MGI:103013. Cacna1c.
Phylogenomic databases
HOVERGEN	HBG050763.
InParanoid	Q0PCR6.
KO	K04850.
Gene expression databases
ArrayExpress	Q0PCR6.
Bgee	Q0PCR6.
Genevestigator	Q0PCR6.
Family and domain databases
InterPro	IPR005821. Ion_trans_dom. IPR014873. VDCC_a1su_IQ. IPR005451. VDCC_L_a1csu. IPR005446. VDCC_L_a1su. IPR002077. VDCCAlpha1. [Graphical view]
PANTHER	PTHR10037:SF47. PTHR10037:SF47. 1 hit.
Pfam	PF08763. Ca_chan_IQ. 1 hit. PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01630. LVDCCALPHA1. PR01635. LVDCCALPHA1C.
SMART	SM01062. Ca_chan_IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q0PCR6.
ChiTaRS	CACNA1C. mouse.
NextBio	280766.
SOURCE	Search...

Entry information

Entry name

Q0PCR6_MOUSE

Accession

Primary (citable) accession number: Q0PCR6

Entry history

Integrated into UniProtKB/TrEMBL:	September 19, 2006
Last sequence update:	September 19, 2006
Last modified:	March 6, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)