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Q0PCR6

- Q0PCR6_MOUSE

UniProt

Q0PCR6 - Q0PCR6_MOUSE

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Protein
Submitted name:

Voltage-dependent L-type calcium channel subunit alpha-1C

Gene

Cacna1c

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. high voltage-gated calcium channel activity Source: RefGenome
  2. voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  1. adult walking behavior Source: MGI
  2. calcium ion-dependent exocytosis Source: MGI
  3. calcium ion import Source: RefGenome
  4. calcium ion transport Source: MGI
  5. cellular calcium ion homeostasis Source: MGI
  6. glucose homeostasis Source: MGI
  7. growth hormone secretion Source: MGI
  8. insulin secretion Source: MGI
  9. membrane depolarization during action potential Source: RefGenome
  10. regulation of blood pressure Source: MGI
  11. regulation of organ growth Source: MGI
  12. regulation of vasoconstriction Source: MGI
  13. smooth muscle contraction Source: MGI
  14. smooth muscle contraction involved in micturition Source: MGI
  15. synaptic transmission Source: MGI
  16. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Submitted name:
Voltage-dependent L-type calcium channel subunit alpha-1CImported
Submitted name:
Voltage-dependent calcium channel splice variant 1.2-aImported
Gene namesi
Name:Cacna1cImported
Synonyms:CaV1.2-aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:103013. Cacna1c.

Subcellular locationi

Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. caveolar macromolecular signaling complex Source: MGI
  2. dendritic shaft Source: MGI
  3. membrane Source: MGI
  4. neuronal cell body Source: MGI
  5. plasma membrane Source: MGI
  6. T-tubule Source: MGI
  7. voltage-gated calcium channel complex Source: MGI
  8. Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ0PCR6.

Expressioni

Gene expression databases

BgeeiQ0PCR6.
ExpressionAtlasiQ0PCR6. baseline and differential.
GenevestigatoriQ0PCR6.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ0PCR6.
SMRiQ0PCR6. Positions 1642-1670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118827.
HOVERGENiHBG050763.
KOiK04850.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0PCR6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIRAFVQPST PPYQPLSSHS SEETERKFKG KVVHEAQLNC FYISPGGSNY
60 70 80 90 100
GSPRPAHANM NANAAAGLAP EHIPTPGAAL SWQAAIDAAR QAKLMGSAGN
110 120 130 140 150
ATISTVSSTQ RKRQQYGKPK KQGGTTATRP PRALLCLTLK NPIRRACISI
160 170 180 190 200
VEWKPFEIII LLTIFANCVA LAIYIPFPED DSNATNSNLE RVEYLFLIIF
210 220 230 240 250
TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF IIVVVGLFSA ILEQATKADG
260 270 280 290 300
ANALGGKGAG FDVKALRAFR VLRPLRLVSG VPSLQVVLNS IIKAMVPLLH
310 320 330 340 350
IALLVLFVII IYAIIGLELF MGKMHKTCYN QEGIIDVPAE EDPSPCALET
360 370 380 390 400
GHGRQCQNGT VCKPGWDGPK HGITNFDNFA FAMLTVFQCI TMEGWTDVLY
410 420 430 440 450
WMQDAMGYEL PWVYFVSLVI FGSFFVLNLV LGVLSGEFSK EREKAKARGD
460 470 480 490 500
FQKLREKQQL EEDLKGYLDW ITQAEDIDPE NEDEGMDEDK PRNMSMPTSE
510 520 530 540 550
TESVNTENVA GGDIEGENCG ARLAHRISKS KFSRYWRRWN RFCRRKCRAA
560 570 580 590 600
VKSNVFYWLV IFLVFLNTLT IASEHYNQPH WLTEVQDTAN KALLALFTAE
610 620 630 640 650
MLLKMYSLGL QAYFVSLFNR FDCFIVCGGI LETILVETKI MSPLGISVLR
660 670 680 690 700
CVRLLRIFKI TRYWNSLSNL VASLLNSVRS IASLLLLLFL FIIIFSLLGM
710 720 730 740 750
QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF QILTGEDWNS VMYDGIMAYG
760 770 780 790 800
GPSFPGMLVC IYFIILFICG NYILLNVFLA IAVDNLADAE SLTSAQKEEE
810 820 830 840 850
EEKERKKLAR TASPEKKQEV MEKPAVEESK EEKIELKSIT ADGESPPTTK
860 870 880 890 900
INMDDLQPSE NEDKSPHSNP DTAGEEDEEE PEMPVGPRPR PLSELHLKEK
910 920 930 940 950
AVPMPEASAF FIFSPNNRFR LQCHRIVNDT IFTNLILFFI LLSSISLAAE
960 970 980 990 1000
DPVQHTSFRN HILGNADYVF TSIFTLEIIL KMTAYGAFLH KGSFCRNYFN
1010 1020 1030 1040 1050
ILDLLVVSVS LISFGIQSSA INVVKILRVL RVLRPLRAIN RAKGLKHVVQ
1060 1070 1080 1090 1100
CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL FKGKLYTCSD SSKQTEAECK
1110 1120 1130 1140 1150
GNYITYKDGE VDHPIIQPRS WENSKFDFDN VLAAMMALFT VSTFEGWPEL
1160 1170 1180 1190 1200
LYRSIDSHTE DKGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ
1210 1220 1230 1240 1250
EQGEQEYKNC ELDKNQRQCV EYALKARPLR RYIPKNQHQY KVWYVVNSTY
1260 1270 1280 1290 1300
FEYLMFVLIL LNTICLAMQH YGQSCLFKIA MNILNMLFTG LFTVEMILKL
1310 1320 1330 1340 1350
IAFKPKGYFS DPWNVFDFLI VIGSIIDVIL SETNPAEHTQ CSPSMSAEEN
1360 1370 1380 1390 1400
SRISITFFRL FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIVML
1410 1420 1430 1440 1450
FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ TFPQAVLLLF RCATGEAWQD
1460 1470 1480 1490 1500
IMLACMPGKK CAPESEPSNS TEGETPCGSS FAVFYFISFY MLCAFLIINL
1510 1520 1530 1540 1550
FVAVIMDNFD YLTRDWSILG PHHLDEFKRI WAEYDPEAKG RIKHLDVVTL
1560 1570 1580 1590 1600
LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL NSDGTVMFNA TLFALVRTAL
1610 1620 1630 1640 1650
RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL LDQVVPPAGD DEVTVGKFYA
1660 1670 1680 1690 1700
TFLIQEYFRK FKKRKEQGLV GKPSQRNALS LQAGLRTLHD IGPEIRRAIS
1710 1720 1730 1740 1750
GDLTAEEELD KAMKEAVSAA SEDDIFRRAG GLFGNHVTYY QSDSRGNFPQ
1760 1770 1780 1790 1800
TFATQRPLHI NKTGNNQADT ESPSHEKLVD STFTPSSYSS TGSNANINNA
1810 1820 1830 1840 1850
NNTALGRFPH PAGYSSTVST VEGHGPPLSP AVRVQEAAWK LSSKRCHSRE
1860 1870 1880 1890 1900
SQGATVNQEI FPDETRSVRM SEEAEYCSEP SLLSTDMFSY QEDEHRQLTC
1910 1920 1930 1940 1950
PEEDKREIQP SPKRSFLRSA SLGRRASFHL ECLKRQKDQG GDISQKTALP
1960 1970 1980 1990 2000
LHLVHHQALA VAGLSPLLQR SHSPTTFPRP CPTPPVTPGS RGRPLRPIPT
2010 2020 2030 2040 2050
LRLEGAESSE KLNSSFPSIH CSSWSEETTA CSGSSSMARR ARPVSLTVPS
2060 2070 2080 2090 2100
QAGAPGRQFH GSASSLVEAV LISEGLGQFA QDPKFIEVTT QELADACDMT
2110 2120 2130 2140 2150
IEEMENAADN ILSGGAQQSP NGTLLPFVNC RDPGQDRAVA PEDESCAYAL
2160
GRGRSEEALA DSRSYVSNL
Length:2,169
Mass (Da):243,370
Last modified:September 19, 2006 - v1
Checksum:i39764022409F63E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC036121 Genomic DNA. No translation available.
AC115816 Genomic DNA. No translation available.
AC126453 Genomic DNA. No translation available.
AC127328 Genomic DNA. No translation available.
AC163353 Genomic DNA. No translation available.
AB259049 mRNA. Translation: BAF03165.1.
RefSeqiNP_001153005.1. NM_001159533.2.
NP_001153006.1. NM_001159534.2.
NP_001153007.1. NM_001159535.2.
NP_033911.2. NM_009781.4.
UniGeneiMm.41628.
Mm.436656.

Genome annotation databases

EnsembliENSMUST00000186889; ENSMUSP00000140056; ENSMUSG00000051331.
GeneIDi12288.
KEGGimmu:12288.
UCSCiuc009dlu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC036121 Genomic DNA. No translation available.
AC115816 Genomic DNA. No translation available.
AC126453 Genomic DNA. No translation available.
AC127328 Genomic DNA. No translation available.
AC163353 Genomic DNA. No translation available.
AB259049 mRNA. Translation: BAF03165.1 .
RefSeqi NP_001153005.1. NM_001159533.2.
NP_001153006.1. NM_001159534.2.
NP_001153007.1. NM_001159535.2.
NP_033911.2. NM_009781.4.
UniGenei Mm.41628.
Mm.436656.

3D structure databases

ProteinModelPortali Q0PCR6.
SMRi Q0PCR6. Positions 1642-1670.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q0PCR6.

Proteomic databases

PRIDEi Q0PCR6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000186889 ; ENSMUSP00000140056 ; ENSMUSG00000051331 .
GeneIDi 12288.
KEGGi mmu:12288.
UCSCi uc009dlu.2. mouse.

Organism-specific databases

CTDi 775.
MGIi MGI:103013. Cacna1c.

Phylogenomic databases

GeneTreei ENSGT00760000118827.
HOVERGENi HBG050763.
KOi K04850.

Miscellaneous databases

ChiTaRSi CACNA1C. mouse.
NextBioi 280766.
SOURCEi Search...

Gene expression databases

Bgeei Q0PCR6.
ExpressionAtlasi Q0PCR6. baseline and differential.
Genevestigatori Q0PCR6.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTi SM01062. Ca_chan_IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit."
    Murakami M., Ohba T., Takahashi Y., Watanabe H., Miyoshi I., Nakayama S., Ono K., Ito H., Iijima T.
    J. Mol. Cell. Cardiol. 41:115-125(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeartImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (SEP-2014) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ0PCR6_MOUSE
AccessioniPrimary (citable) accession number: Q0PCR6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 19, 2006
Last sequence update: September 19, 2006
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3