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Q0PCR5

- Q0PCR5_MOUSE

UniProt

Q0PCR5 - Q0PCR5_MOUSE

Protein
Submitted name:

Voltage-dependent calcium channel splice variant 1.2-b

Gene

Cacna1c

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (19 Sep 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. high voltage-gated calcium channel activity Source: RefGenome
    2. protein binding Source: MGI
    3. voltage-gated calcium channel activity Source: MGI

    GO - Biological processi

    1. adult walking behavior Source: MGI
    2. calcium ion-dependent exocytosis Source: MGI
    3. calcium ion import Source: RefGenome
    4. calcium ion transport Source: MGI
    5. cellular calcium ion homeostasis Source: MGI
    6. glucose homeostasis Source: MGI
    7. growth hormone secretion Source: MGI
    8. insulin secretion Source: MGI
    9. membrane depolarization during action potential Source: RefGenome
    10. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    11. regulation of blood pressure Source: MGI
    12. regulation of organ growth Source: MGI
    13. regulation of vasoconstriction Source: MGI
    14. smooth muscle contraction Source: MGI
    15. smooth muscle contraction involved in micturition Source: MGI
    16. synaptic transmission Source: MGI
    17. visual learning Source: MGI

    Keywords - Molecular functioni

    Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Voltage-dependent calcium channel splice variant 1.2-bImported
    Gene namesi
    Name:Cacna1cImported
    Synonyms:CaV1.2-bImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:103013. Cacna1c.

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. caveolar macromolecular signaling complex Source: MGI
    2. dendritic shaft Source: MGI
    3. membrane Source: MGI
    4. neuronal cell body Source: MGI
    5. plasma membrane Source: MGI
    6. postsynaptic density Source: Ensembl
    7. T-tubule Source: MGI
    8. voltage-gated calcium channel complex Source: MGI
    9. Z disc Source: MGI

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiQ0PCR5.
    BgeeiQ0PCR5.
    GenevestigatoriQ0PCR5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0PCR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Family and domain databases

    InterProiIPR005821. Ion_trans_dom.
    IPR002077. VDCCAlpha1.
    [Graphical view]
    PfamiPF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00167. CACHANNEL.

    Sequencei

    Sequence statusi: Fragment.

    Q0PCR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV LGVLSGEFSK    50
    EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE NEDEGMDEDK 100
    PRNRGAPAGL HDQKKGKFAW FSHSTETHVS MPTSETES 138
    Length:138
    Mass (Da):15,927
    Last modified:September 19, 2006 - v1
    Checksum:iC9528C40B999AF89
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei138 – 1381Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB259050 mRNA. Translation: BAF03166.1.
    UniGeneiMm.41628.
    Mm.436656.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB259050 mRNA. Translation: BAF03166.1 .
    UniGenei Mm.41628.
    Mm.436656.

    3D structure databases

    ProteinModelPortali Q0PCR5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:103013. Cacna1c.

    Miscellaneous databases

    ChiTaRSi CACNA1C. mouse.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q0PCR5.
    Bgeei Q0PCR5.
    Genevestigatori Q0PCR5.

    Family and domain databases

    InterProi IPR005821. Ion_trans_dom.
    IPR002077. VDCCAlpha1.
    [Graphical view ]
    Pfami PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00167. CACHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit."
      Murakami M., Ohba T., Takahashi Y., Watanabe H., Miyoshi I., Nakayama S., Ono K., Ito H., Iijima T.
      J. Mol. Cell. Cardiol. 41:115-125(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: AortaImported.

    Entry informationi

    Entry nameiQ0PCR5_MOUSE
    AccessioniPrimary (citable) accession number: Q0PCR5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 19, 2006
    Last sequence update: September 19, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)