Q0PCR5 (Q0PCR5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Voltage-dependent calcium channel splice variant 1.2-b EMBL BAF03166.1

Gene names

Name:	Cacna1c MGI 103013
Synonyms:	CaV1.2-b EMBL BAF03166.1

Organism

Mus musculus (Mouse) EMBL BAF03166.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	138 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification] RuleBase RU003808

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808 Ion channel Voltage-gated channel RuleBase RU003808
Gene Ontology (GO)
Biological_process	adult walking behavior Inferred from genetic interaction PubMed 9882694. Source: MGI calcium ion-dependent exocytosis Inferred from mutant phenotype PubMed 12881419. Source: MGI cellular calcium ion homeostasis Inferred from mutant phenotype PubMed 15132976. Source: MGI elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara glucose homeostasis Inferred from mutant phenotype PubMed 12881419. Source: MGI growth hormone secretion Inferred from direct assay PubMed 1385406. Source: MGI insulin secretion Inferred from mutant phenotype PubMed 12881419. Source: MGI regulation of blood pressure Inferred from mutant phenotype PubMed 14609949. Source: MGI regulation of organ growth Inferred from mutant phenotype PubMed 15132976. Source: MGI regulation of vasoconstriction Inferred from mutant phenotype PubMed 14609949. Source: MGI smooth muscle contraction involved in micturition Inferred from mutant phenotype PubMed 15132976. Source: MGI synaptic transmission Inferred from mutant phenotype PubMed 16251435. Source: MGI visual learning Inferred from mutant phenotype PubMed 16251435. Source: MGI
Cellular_component	T-tubule Traceable author statement PubMed 11784029. Source: MGI Z disc Inferred from direct assay PubMed 19383796. Source: MGI caveolar macromolecular signaling complex Inferred from direct assay PubMed 16648270. Source: MGI dendritic shaft Inferred from direct assay PubMed 15090038. Source: MGI neuronal cell body Inferred from direct assay PubMed 15090038. Source: MGI postsynaptic density Inferred from electronic annotation. Source: Compara voltage-gated calcium channel complex Traceable author statement PubMed 11296258. Source: MGI
Molecular_function	voltage-gated calcium channel activity Inferred from direct assay PubMed 1385406PubMed 16267232PubMed 7635187PubMed 7814415. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAF03166.1
	Non-terminal residue	138	1	EMBL BAF03166.1

Sequences

	Sequence		Length	Mass (Da)
	Q0PCR5 [UniParc]. Last modified September 19, 2006. Version 1. Checksum: C9528C40B999AF89	FASTA	138	15,927
	10 20 30 40 50 60 TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV LGVLSGEFSK EREKAKARGD 70 80 90 100 110 120 FQKLREKQQL EEDLKGYLDW ITQAEDIDPE NEDEGMDEDK PRNRGAPAGL HDQKKGKFAW 130 FSHSTETHVS MPTSETES

References

[1]	"Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit." Murakami M., Ohba T., Takahashi Y., Watanabe H., Miyoshi I., Nakayama S., Ono K., Ito H., Iijima T. J. Mol. Cell. Cardiol. 41:115-125(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Aorta EMBL BAF03166.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB259050 mRNA. Translation: BAF03166.1.
IPI	IPI00229513.
UniGene	Mm.436656.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:103013. Cacna1c.
Gene expression databases
ArrayExpress	Q0PCR5.
Bgee	Q0PCR5.
Genevestigator	Q0PCR5.
Family and domain databases
InterPro	IPR005821. Ion_trans_dom. IPR002077. VDCCAlpha1. [Graphical view]
Pfam	PF00520. Ion_trans. 1 hit. [Graphical view]
PRINTS	PR00167. CACHANNEL.
ProtoNet	Search...
Other
ChiTaRS	CACNA1C. mouse.
SOURCE	Search...

Entry information

Entry name

Q0PCR5_MOUSE

Accession

Primary (citable) accession number: Q0PCR5

Entry history

Integrated into UniProtKB/TrEMBL:	September 19, 2006
Last sequence update:	September 19, 2006
Last modified:	May 29, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)