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Protein
Submitted name:

Voltage-dependent calcium channel splice variant 1.2-b

Gene

Cacna1c

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • adult walking behavior Source: MGI
  • calcium ion-dependent exocytosis Source: MGI
  • calcium ion import Source: GO_Central
  • calcium ion transport Source: MGI
  • cellular calcium ion homeostasis Source: MGI
  • glucose homeostasis Source: MGI
  • growth hormone secretion Source: MGI
  • insulin secretion Source: MGI
  • membrane depolarization during action potential Source: GO_Central
  • positive regulation of cytosolic calcium ion concentration Source: MGI
  • regulation of blood pressure Source: MGI
  • regulation of organ growth Source: MGI
  • regulation of vasoconstriction Source: MGI
  • smooth muscle contraction Source: MGI
  • smooth muscle contraction involved in micturition Source: MGI
  • synaptic transmission Source: MGI
  • visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Submitted name:
Voltage-dependent calcium channel splice variant 1.2-bImported
Gene namesi
Name:Cacna1cImported
Synonyms:CaV1.2-bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:103013. Cacna1c.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  • caveolar macromolecular signaling complex Source: MGI
  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • dendritic shaft Source: MGI
  • integral component of membrane Source: MGI
  • membrane Source: MGI
  • neuronal cell body Source: MGI
  • plasma membrane Source: MGI
  • postsynaptic density Source: MGI
  • T-tubule Source: MGI
  • voltage-gated calcium channel complex Source: MGI
  • Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiQ0PCR5.
ExpressionAtlasiQ0PCR5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108413.

Structurei

3D structure databases

ProteinModelPortaliQ0PCR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR005451. VDCC_L_a1csu.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF188. PTHR10037:SF188. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00167. CACHANNEL.

Sequencei

Sequence statusi: Fragment.

Q0PCR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV LGVLSGEFSK
60 70 80 90 100
EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE NEDEGMDEDK
110 120 130
PRNRGAPAGL HDQKKGKFAW FSHSTETHVS MPTSETES
Length:138
Mass (Da):15,927
Last modified:September 19, 2006 - v1
Checksum:iC9528C40B999AF89
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei138 – 1381Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB259050 mRNA. Translation: BAF03166.1.
UniGeneiMm.41628.
Mm.436656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB259050 mRNA. Translation: BAF03166.1.
UniGeneiMm.41628.
Mm.436656.

3D structure databases

ProteinModelPortaliQ0PCR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:103013. Cacna1c.

Miscellaneous databases

ChiTaRSiCacna1c. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ0PCR5.
ExpressionAtlasiQ0PCR5. baseline and differential.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR005451. VDCC_L_a1csu.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF188. PTHR10037:SF188. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
ProtoNetiSearch...

Publicationsi

  1. "Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit."
    Murakami M., Ohba T., Takahashi Y., Watanabe H., Miyoshi I., Nakayama S., Ono K., Ito H., Iijima T.
    J. Mol. Cell. Cardiol. 41:115-125(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: AortaImported.

Entry informationi

Entry nameiQ0PCR5_MOUSE
AccessioniPrimary (citable) accession number: Q0PCR5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 19, 2006
Last sequence update: September 19, 2006
Last modified: July 22, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.