Unreviewed, UniProtKB/TrEMBL Q0PBY8 (Q0PBY8_CAMJE)

Names and origin

Protein names

Recommended name:
    Homoserine dehydrogenase RuleBase RU000579V2
    EC=1.1.1.3

Gene names

Name:	hom EMBL CAL34320.1
Ordered Locus Names:	Cj0149c

Organism

Campylobacter jejuni [Complete proteome] [HAMAP]

Taxonomic identifier

197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H. RuleBase RU000579V2
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3. RuleBase RU000579V2 Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5. RuleBase RU000579V2
Sequence similarities	Belongs to the homoserine dehydrogenase family. RuleBase RU004171V0

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis Isoleucine biosynthesis RuleBase RU000579V2 Methionine biosynthesis RuleBase RU000579V2 Threonine biosynthesis RuleBase RU000579V2
Ligand	NADP RuleBase RU000579V2
Molecular function	Oxidoreductase RuleBase RU000579V2
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	amino acid biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro amino acid binding Inferred from electronic annotation. Source: InterPro homoserine dehydrogenase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
fliM	Q0PC73	1	EBI-1193963,EBI-1191095

Sequences

	Sequence		Length	Mass (Da)
	Q0PBY8-1 [UniParc]. Last modified September 19, 2006. Version 1. Checksum: 4B69D3A85B410923	FASTA	415	45,919
	10 20 30 40 50 60 MKVAILGYGT VGSAVVKFLL ENDKLIRARC GQSITPVIAL ARSPKKNALI PITHSVAEIL 70 80 90 100 110 120 NADVDVFVEL MGGVDEAFKI VSEILKKKKA VVTANKAMLA YHRYELENLA KNLAFGYEAS 130 140 150 160 170 180 VAGGIPIIKV LKEGLSANNI LAIKGILNGT SNYILSSMSQ KNMSFKQALQ IAQNLGYAEA 190 200 210 220 230 240 DPTFDIEGQD AAHKLLVLSS IAYNLKAKPE DILIEGISEI APEDMYFANE FEFTIKLLGI 250 260 270 280 290 300 AKVRENKVEL RVHPTMIDKE KMLAKVDGVM NAISINGDLL GESLYYGAGA GGEATASAVI 310 320 330 340 350 360 SDLMDIARDQ VKAPMLGFVN TLEYKLLSKD EIYTKYYLRV KVEDKIGILS KITQLMSENN 370 380 390 400 410 ISIDSFLQKP KKNDENYSTL FFTTHLTYEK SIQNLLEILR KQDFIKTKPF MMRIE

References

[1]

"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL111168 Genomic DNA. Translation: CAL34320.1.
PIR	E81432.
RefSeq	YP_002343609.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q0PBY8. 20 interactions.
Genome annotation databases
GeneID	904482.
GenomeReviews	Gene locus Cj0149c in contig AL111168_GR.
KEGG	cje:Cj0149c.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0PBY8.
OMA	Q0PBY8. LGIVNGT.
Family and domain databases
InterPro	IPR002912. ACT_bd. IPR005106. Asp/hSer_DH_NAD-bd. IPR016204. Homoserine_dehydrogenase. IPR001342. Homoserine_dehydrogenase_cat. IPR019811. Homoserine_dehydrogenase_CS. [Graphical view]
Pfam	PF01842. ACT. 1 hit. PF00742. Homoserine_dh. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view]
PIRSF	PIRSF000098. Homoser_dehydrog. 1 hit.
PROSITE	PS01042. HOMOSER_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q0PBY8_CAMJE

Accession

Primary (citable) accession number: Q0PBY8

Entry history

Integrated into UniProtKB/TrEMBL:	September 19, 2006
Last sequence update:	September 19, 2006
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)