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Protein

Type III pantothenate kinase

Gene

coaX

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Cofactori

NH4(+)UniRule annotation, K+UniRule annotationNote: A monovalent cation. Ammonium or potassium.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68SubstrateUniRule annotation1
Active sitei74Proton acceptorUniRule annotation1
Metal bindingi89Monovalent cationUniRule annotation1
Binding sitei92ATPUniRule annotation1
Binding sitei144SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi5 – 12ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-362-MONOMER.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Type III pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaXUniRule annotation
Ordered Locus Names:Cj0394c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002675041 – 209Type III pantothenate kinaseAdd BLAST209

Proteomic databases

PaxDbiQ0PBB6.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ0PBB6. 7 interactors.
STRINGi192222.Cj0394c.

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Beta strandi8 – 14Combined sources7
Beta strandi19 – 23Combined sources5
Helixi24 – 29Combined sources6
Beta strandi37 – 40Combined sources4
Helixi43 – 45Combined sources3
Helixi46 – 51Combined sources6
Helixi59 – 61Combined sources3
Helixi73 – 79Combined sources7
Beta strandi83 – 100Combined sources18
Beta strandi107 – 111Combined sources5
Helixi113 – 123Combined sources11
Beta strandi137 – 139Combined sources3
Helixi144 – 163Combined sources20
Turni164 – 166Combined sources3
Beta strandi169 – 173Combined sources5
Helixi176 – 180Combined sources5
Beta strandi184 – 188Combined sources5
Helixi192 – 203Combined sources12
Helixi205 – 207Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NRHX-ray2.30A/B2-209[»]
ProteinModelPortaliQ0PBB6.
SMRiQ0PBB6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ0PBB6.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni72 – 75Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the type III pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108VHG. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000103340.
KOiK03525.
OMAiFHLETDY.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3. 1 hit.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0PBB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLCDIGNSN ANFLDDNKYF TLNIDQFLEF KNEQKIFYIN VNEHLKEHLK
60 70 80 90 100
NQKNFINLEP YFLFDTIYQG LGIDRIAACY TIEDGVVVDA GSAITIDIIS
110 120 130 140 150
NSIHLGGFIL PGIANYKKIY SHISPRLKSE FNTQVSLDAF PQKTMDALSY
160 170 180 190 200
GVFKGIYLLI KDAAQNKKLY FTGGDGQFLA NYFDHAIYDK LLIFRGMKKI

IKENPNLLY
Length:209
Mass (Da):23,936
Last modified:September 19, 2006 - v1
Checksum:iC49313AA9E3D2D19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34544.1.
PIRiH81382.
RefSeqiWP_002864777.1. NC_002163.1.
YP_002343831.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34544; CAL34544; Cj0394c.
GeneIDi904717.
KEGGicje:Cj0394c.
PATRICi20057703. VBICamJej33762_0385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34544.1.
PIRiH81382.
RefSeqiWP_002864777.1. NC_002163.1.
YP_002343831.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NRHX-ray2.30A/B2-209[»]
ProteinModelPortaliQ0PBB6.
SMRiQ0PBB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ0PBB6. 7 interactors.
STRINGi192222.Cj0394c.

Proteomic databases

PaxDbiQ0PBB6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL34544; CAL34544; Cj0394c.
GeneIDi904717.
KEGGicje:Cj0394c.
PATRICi20057703. VBICamJej33762_0385.

Phylogenomic databases

eggNOGiENOG4108VHG. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000103340.
KOiK03525.
OMAiFHLETDY.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.
BioCyciCJEJ192222:GJTS-362-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ0PBB6.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3. 1 hit.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOAX_CAMJE
AccessioniPrimary (citable) accession number: Q0PBB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 19, 2006
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.