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Protein

Group 3 truncated hemoglobin ctb

Gene

ctb

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has been suggested to be involved in cytochrome c peroxidase or P450-like oxygen chemistry or cyanide detoxification. The high oxygen affinity of this protein suggests that it probably does not function as an oxygen transporter.

Cofactori

hemeNote: Binds 1 heme group per subunit; upon expression in E.coli it purifies predominantly in the Fe2+-oxy form, binding O(2) tightly even under anaerobic conditions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei64Heme1
Metal bindingi72Iron (heme proximal ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-435-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Group 3 truncated hemoglobin ctb
Short name:
Cj-trHbP
Short name:
Truncated Hb
Gene namesi
Name:ctb
Ordered Locus Names:Cj0465c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene grow less well than wild-type under conditions of high aeration.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi19Y → F: Known as B10, reduces accessible space in the distal pocket, retarding ligand binding. Enlarges distal pocket, facilitating ligand entry; when associated with L-46. 1 Publication1
Mutagenesisi46H → L: Known as E7, reduces accessible space in the distal pocket, retarding ligand binding. Enlarges distal pocket, facilitating ligand entry; when associated with F-19. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003934681 – 127Group 3 truncated hemoglobin ctbAdd BLAST127

Proteomic databases

PaxDbiQ0PB48.

Expressioni

Inductioni

Constitutively expressed, it is further induced by S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP) (at protein level).1 Publication

Interactioni

Subunit structurei

Monomer.2 Publications

Protein-protein interaction databases

IntActiQ0PB48. 54 interactors.
STRINGi192222.Cj0465c.

Structurei

Secondary structure

1127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Helixi8 – 24Combined sources17
Helixi28 – 36Combined sources9
Helixi40 – 58Combined sources19
Helixi68 – 73Combined sources6
Helixi82 – 97Combined sources16
Helixi100 – 121Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IG3X-ray2.15A/B1-127[»]
ProteinModelPortaliQ0PB48.
SMRiQ0PB48.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ0PB48.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105VIG. Bacteria.
COG2346. LUCA.
HOGENOMiHOG000261132.
KOiK06886.
OMAiDFWETNL.

Family and domain databases

InterProiView protein in InterPro
IPR009050. Globin-like_sf.
IPR001486. Hemoglobin_trunc.
PfamiView protein in Pfam
PF01152. Bac_globin. 1 hit.
SUPFAMiSSF46458. SSF46458. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0PB48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFETINQES IAKLMEIFYE KVRKDKDLGP IFNNAIGTSD EEWKEHKAKI
60 70 80 90 100
GNFWAGMLLG EGDYNGQPLK KHLDLPPFPQ EFFEIWLKLF EESLNIVYNE
110 120
EMKNVILQRA QMIASHFQNM LYKYGGH
Length:127
Mass (Da):14,973
Last modified:September 19, 2006 - v1
Checksum:iBCFA4E43C4C9752C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34613.1.
PIRiD81391.
RefSeqiWP_002858471.1. NC_002163.1.
YP_002343899.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34613; CAL34613; Cj0465c.
GeneIDi904788.
KEGGicje:Cj0465c.
PATRICifig|192222.6.peg.457.

Similar proteinsi

Entry informationi

Entry nameiTRHBP_CAMJE
AccessioniPrimary (citable) accession number: Q0PB48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: September 19, 2006
Last modified: November 22, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families