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Q0PAS0

- ALF_CAMJE

UniProt

Q0PAS0 - ALF_CAMJE

Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (19 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Cofactori

    Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei61 – 611Glyceraldehyde 3-phosphateBy similarity
    Active sitei104 – 1041Proton donorBy similarity
    Metal bindingi105 – 1051Zinc 1; catalyticBy similarity
    Metal bindingi139 – 1391Zinc 2By similarity
    Metal bindingi169 – 1691Zinc 2By similarity
    Metal bindingi221 – 2211Zinc 1; catalyticBy similarity
    Binding sitei222 – 2221Dihydroxyacetone phosphate; via amide nitrogenBy similarity
    Metal bindingi260 – 2601Zinc 1; catalyticBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciCJEJ192222:GJTS-584-MONOMER.
    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase (EC:4.1.2.13)
    Short name:
    FBP aldolase
    Short name:
    FBPA
    Alternative name(s):
    Fructose-1,6-bisphosphate aldolase
    Gene namesi
    Name:fba
    Synonyms:fda, fdaC
    Ordered Locus Names:Cj0597
    OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
    Taxonomic identifieri192222 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000000799: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354Fructose-bisphosphate aldolasePRO_0000178711Add
    BLAST

    Proteomic databases

    PRIDEiQ0PAS0.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ0PAS0. 9 interactions.
    STRINGi192222.Cj0597.

    Structurei

    Secondary structure

    1
    354
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 53
    Beta strandi9 – 113
    Helixi14 – 163
    Helixi17 – 2711
    Beta strandi31 – 355
    Helixi39 – 5214
    Beta strandi56 – 605
    Helixi62 – 698
    Helixi76 – 9520
    Beta strandi98 – 1036
    Helixi108 – 1103
    Helixi111 – 12818
    Beta strandi134 – 1374
    Helixi145 – 16117
    Beta strandi165 – 1695
    Turni188 – 1903
    Helixi194 – 20411
    Turni205 – 2073
    Beta strandi211 – 2144
    Helixi234 – 24613
    Beta strandi257 – 2593
    Helixi267 – 2759
    Beta strandi278 – 2836
    Helixi285 – 30218
    Helixi303 – 3053
    Beta strandi306 – 3127
    Beta strandi315 – 3195
    Helixi321 – 3244
    Helixi326 – 34722

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3QM3X-ray1.85A/B/C/D/E/F/G/H1-354[»]
    ProteinModelPortaliQ0PAS0.
    SMRiQ0PAS0. Positions 3-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni261 – 2633Dihydroxyacetone phosphate bindingBy similarity
    Regioni282 – 2854Dihydroxyacetone phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0191.
    HOGENOMiHOG000227794.
    KOiK01624.
    OMAiHNSLDFV.
    OrthoDBiEOG69GZPB.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR006411. Fruct_bisP_bact.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view]
    PfamiPF01116. F_bP_aldolase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsiTIGR00167. cbbA. 1 hit.
    TIGR01520. FruBisAldo_II_A. 1 hit.
    PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0PAS0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVLDIVKAG VISGDELNKI YDYAKAEGFA IPAVNVVGTD SINAVLEAAK    50
    KVNSPVIIQF SNGGAKFYAG KNCPNGEVLG AISGAKHVHL LAKAYGVPVI 100
    LHTDHAARKL LPWIDGLIEA NAQYKKTHGQ ALFSSHMLDL SEESLEENLS 150
    TCEVYLQKLD ALGVALEIEL GCTGGEEDGV DNTGIDNSKL YTQPEDVALA 200
    YERLGKISDK FSIAASFGNV HGVYKPGNVS LQPEILKNSQ KFVKDKFALN 250
    SDKPINFVFH GGSGSELKDI KNAVSYGVIK MNIDTDTQWA FWDGVREYEL 300
    KNRAYLQGQI GNPEGDDKPN KKYYDPRVWL RSGEESMIKR LEIAFEDLNC 350
    INKN 354
    Length:354
    Mass (Da):38,730
    Last modified:September 19, 2006 - v1
    Checksum:iE4ACB44EA1860135
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL111168 Genomic DNA. Translation: CAL34743.1.
    PIRiS52413.
    RefSeqiYP_002344027.1. NC_002163.1.

    Genome annotation databases

    EnsemblBacteriaiCAL34743; CAL34743; Cj0597.
    GeneIDi904922.
    KEGGicje:Cj0597.
    PATRICi20058138. VBICamJej33762_0589.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL111168 Genomic DNA. Translation: CAL34743.1 .
    PIRi S52413.
    RefSeqi YP_002344027.1. NC_002163.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3QM3 X-ray 1.85 A/B/C/D/E/F/G/H 1-354 [» ]
    ProteinModelPortali Q0PAS0.
    SMRi Q0PAS0. Positions 3-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q0PAS0. 9 interactions.
    STRINGi 192222.Cj0597.

    Proteomic databases

    PRIDEi Q0PAS0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL34743 ; CAL34743 ; Cj0597 .
    GeneIDi 904922.
    KEGGi cje:Cj0597.
    PATRICi 20058138. VBICamJej33762_0589.

    Phylogenomic databases

    eggNOGi COG0191.
    HOGENOMi HOG000227794.
    KOi K01624.
    OMAi HNSLDFV.
    OrthoDBi EOG69GZPB.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .
    BioCyci CJEJ192222:GJTS-584-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR006411. Fruct_bisP_bact.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view ]
    Pfami PF01116. F_bP_aldolase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsi TIGR00167. cbbA. 1 hit.
    TIGR01520. FruBisAldo_II_A. 1 hit.
    PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 11168.

    Entry informationi

    Entry nameiALF_CAMJE
    AccessioniPrimary (citable) accession number: Q0PAS0
    Secondary accession number(s): P53818
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: September 19, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3