Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q0PAS0

- ALF_CAMJE

UniProt

Q0PAS0 - ALF_CAMJE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611Glyceraldehyde 3-phosphateBy similarity
Active sitei104 – 1041Proton donorBy similarity
Metal bindingi105 – 1051Zinc 1; catalyticBy similarity
Metal bindingi139 – 1391Zinc 2By similarity
Metal bindingi169 – 1691Zinc 2By similarity
Metal bindingi221 – 2211Zinc 1; catalyticBy similarity
Binding sitei222 – 2221Dihydroxyacetone phosphate; via amide nitrogenBy similarity
Metal bindingi260 – 2601Zinc 1; catalyticBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-584-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Synonyms:fda, fdaC
Ordered Locus Names:Cj0597
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Fructose-bisphosphate aldolasePRO_0000178711Add
BLAST

Proteomic databases

PRIDEiQ0PAS0.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ0PAS0. 9 interactions.
STRINGi192222.Cj0597.

Structurei

Secondary structure

1
354
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53
Beta strandi9 – 113
Helixi14 – 163
Helixi17 – 2711
Beta strandi31 – 355
Helixi39 – 5214
Beta strandi56 – 605
Helixi62 – 698
Helixi76 – 9520
Beta strandi98 – 1036
Helixi108 – 1103
Helixi111 – 12818
Beta strandi134 – 1374
Helixi145 – 16117
Beta strandi165 – 1695
Turni188 – 1903
Helixi194 – 20411
Turni205 – 2073
Beta strandi211 – 2144
Helixi234 – 24613
Beta strandi257 – 2593
Helixi267 – 2759
Beta strandi278 – 2836
Helixi285 – 30218
Helixi303 – 3053
Beta strandi306 – 3127
Beta strandi315 – 3195
Helixi321 – 3244
Helixi326 – 34722

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QM3X-ray1.85A/B/C/D/E/F/G/H1-354[»]
ProteinModelPortaliQ0PAS0.
SMRiQ0PAS0. Positions 3-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni261 – 2633Dihydroxyacetone phosphate bindingBy similarity
Regioni282 – 2854Dihydroxyacetone phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
HOGENOMiHOG000227794.
KOiK01624.
OMAiHNSLDFV.
OrthoDBiEOG69GZPB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0PAS0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGVLDIVKAG VISGDELNKI YDYAKAEGFA IPAVNVVGTD SINAVLEAAK
60 70 80 90 100
KVNSPVIIQF SNGGAKFYAG KNCPNGEVLG AISGAKHVHL LAKAYGVPVI
110 120 130 140 150
LHTDHAARKL LPWIDGLIEA NAQYKKTHGQ ALFSSHMLDL SEESLEENLS
160 170 180 190 200
TCEVYLQKLD ALGVALEIEL GCTGGEEDGV DNTGIDNSKL YTQPEDVALA
210 220 230 240 250
YERLGKISDK FSIAASFGNV HGVYKPGNVS LQPEILKNSQ KFVKDKFALN
260 270 280 290 300
SDKPINFVFH GGSGSELKDI KNAVSYGVIK MNIDTDTQWA FWDGVREYEL
310 320 330 340 350
KNRAYLQGQI GNPEGDDKPN KKYYDPRVWL RSGEESMIKR LEIAFEDLNC

INKN
Length:354
Mass (Da):38,730
Last modified:September 19, 2006 - v1
Checksum:iE4ACB44EA1860135
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34743.1.
PIRiS52413.
RefSeqiYP_002344027.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34743; CAL34743; Cj0597.
GeneIDi904922.
KEGGicje:Cj0597.
PATRICi20058138. VBICamJej33762_0589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34743.1 .
PIRi S52413.
RefSeqi YP_002344027.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3QM3 X-ray 1.85 A/B/C/D/E/F/G/H 1-354 [» ]
ProteinModelPortali Q0PAS0.
SMRi Q0PAS0. Positions 3-352.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q0PAS0. 9 interactions.
STRINGi 192222.Cj0597.

Proteomic databases

PRIDEi Q0PAS0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL34743 ; CAL34743 ; Cj0597 .
GeneIDi 904922.
KEGGi cje:Cj0597.
PATRICi 20058138. VBICamJej33762_0589.

Phylogenomic databases

eggNOGi COG0191.
HOGENOMi HOG000227794.
KOi K01624.
OMAi HNSLDFV.
OrthoDBi EOG69GZPB.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci CJEJ192222:GJTS-584-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiALF_CAMJE
AccessioniPrimary (citable) accession number: Q0PAS0
Secondary accession number(s): P53818
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 19, 2006
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3