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Q0PAS0

- ALF_CAMJE

UniProt

Q0PAS0 - ALF_CAMJE

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Protein
Fructose-bisphosphate aldolase
Gene
fba, fda, fdaC, Cj0597
Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis By similarity.

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611Glyceraldehyde 3-phosphate By similarity
Active sitei104 – 1041Proton donor By similarity
Metal bindingi105 – 1051Zinc 1; catalytic By similarity
Metal bindingi139 – 1391Zinc 2 By similarity
Metal bindingi169 – 1691Zinc 2 By similarity
Metal bindingi221 – 2211Zinc 1; catalytic By similarity
Binding sitei222 – 2221Dihydroxyacetone phosphate; via amide nitrogen By similarity
Metal bindingi260 – 2601Zinc 1; catalytic By similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-584-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Synonyms:fda, fdaC
Ordered Locus Names:Cj0597
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Fructose-bisphosphate aldolase
PRO_0000178711Add
BLAST

Proteomic databases

PRIDEiQ0PAS0.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

IntActiQ0PAS0. 9 interactions.
STRINGi192222.Cj0597.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53
Beta strandi9 – 113
Helixi14 – 163
Helixi17 – 2711
Beta strandi31 – 355
Helixi39 – 5214
Beta strandi56 – 605
Helixi62 – 698
Helixi76 – 9520
Beta strandi98 – 1036
Helixi108 – 1103
Helixi111 – 12818
Beta strandi134 – 1374
Helixi145 – 16117
Beta strandi165 – 1695
Turni188 – 1903
Helixi194 – 20411
Turni205 – 2073
Beta strandi211 – 2144
Helixi234 – 24613
Beta strandi257 – 2593
Helixi267 – 2759
Beta strandi278 – 2836
Helixi285 – 30218
Helixi303 – 3053
Beta strandi306 – 3127
Beta strandi315 – 3195
Helixi321 – 3244
Helixi326 – 34722

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QM3X-ray1.85A/B/C/D/E/F/G/H1-354[»]
ProteinModelPortaliQ0PAS0.
SMRiQ0PAS0. Positions 3-352.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni261 – 2633Dihydroxyacetone phosphate binding By similarity
Regioni282 – 2854Dihydroxyacetone phosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
HOGENOMiHOG000227794.
KOiK01624.
OMAiHNSLDFV.
OrthoDBiEOG69GZPB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0PAS0-1 [UniParc]FASTAAdd to Basket

« Hide

MGVLDIVKAG VISGDELNKI YDYAKAEGFA IPAVNVVGTD SINAVLEAAK    50
KVNSPVIIQF SNGGAKFYAG KNCPNGEVLG AISGAKHVHL LAKAYGVPVI 100
LHTDHAARKL LPWIDGLIEA NAQYKKTHGQ ALFSSHMLDL SEESLEENLS 150
TCEVYLQKLD ALGVALEIEL GCTGGEEDGV DNTGIDNSKL YTQPEDVALA 200
YERLGKISDK FSIAASFGNV HGVYKPGNVS LQPEILKNSQ KFVKDKFALN 250
SDKPINFVFH GGSGSELKDI KNAVSYGVIK MNIDTDTQWA FWDGVREYEL 300
KNRAYLQGQI GNPEGDDKPN KKYYDPRVWL RSGEESMIKR LEIAFEDLNC 350
INKN 354
Length:354
Mass (Da):38,730
Last modified:September 19, 2006 - v1
Checksum:iE4ACB44EA1860135
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34743.1.
PIRiS52413.
RefSeqiYP_002344027.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34743; CAL34743; Cj0597.
GeneIDi904922.
KEGGicje:Cj0597.
PATRICi20058138. VBICamJej33762_0589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34743.1 .
PIRi S52413.
RefSeqi YP_002344027.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3QM3 X-ray 1.85 A/B/C/D/E/F/G/H 1-354 [» ]
ProteinModelPortali Q0PAS0.
SMRi Q0PAS0. Positions 3-352.
ModBasei Search...

Protein-protein interaction databases

IntActi Q0PAS0. 9 interactions.
STRINGi 192222.Cj0597.

Proteomic databases

PRIDEi Q0PAS0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL34743 ; CAL34743 ; Cj0597 .
GeneIDi 904922.
KEGGi cje:Cj0597.
PATRICi 20058138. VBICamJej33762_0589.

Phylogenomic databases

eggNOGi COG0191.
HOGENOMi HOG000227794.
KOi K01624.
OMAi HNSLDFV.
OrthoDBi EOG69GZPB.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci CJEJ192222:GJTS-584-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiALF_CAMJE
AccessioniPrimary (citable) accession number: Q0PAS0
Secondary accession number(s): P53818
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 19, 2006
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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