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Reviewed, UniProtKB/Swiss-Prot Q0P891 (DPS_CAMJE)

Last modified June 16, 2009. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    DNA protection during starvation protein
    EC=1.16.-.-
Gene names
Name: dps
Ordered Locus Names: Cj1534c
OrganismCampylobacter jejuni [Complete proteome] [HAMAP]
Taxonomic identifier197 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Protein attributes

Sequence length149 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction Probable. Does not bind DNA.

Catalytic activity

2 Fe2+ + H2O2 + 2 H+ = 2 Fe3+ + 2 H2O.

Subunit structure

Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe3+ can be deposited By similarity.

Subcellular location

Cytoplasm By similarity.

Induction

Constitutively expressed. Not induced by hydrogen peroxide or by iron.

Sequence similarities

Belongs to the dps family.

Ontologies

Keywords
   Biological processIron storage
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

response to stress

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferric iron binding

Inferred from electronic annotation. Source: InterPro

oxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

fliYQ0PC741EBI-1192444,EBI-1191111

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 149149DNA protection during starvation protein
PRO_0000253339

Sites

Metal binding251Iron 1; shared with dodecameric partner By similarity
Metal binding521Iron 1 By similarity
Metal binding561Iron 1 By similarity
Metal binding561Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0P891-1 [UniParc].

Last modified September 19, 2006. Version 1.
Checksum: 203EB8DE513D0884

FASTA14917,205
        10         20         30         40         50         60 
MSVTKQLLQM QADAHHLWVK FHNYHWNVKG LQFFSIHEYT EKAYEEMAEL FDSCAERVLQ 

        70         80         90        100        110        120 
LGEKAITCQK VLMENAKSPK VAKDCFTPLE VIELIKQDYE YLLAEFKKLN EAAEKESDTT 

       130        140 
TAAFAQENIA KYEKSLWMIG ATLQGACKM 

« Hide

References

« Hide 'large scale' references
[1]"The iron-binding protein Dps confers hydrogen peroxide stress resistance to Campylobacter jejuni."
Ishikawa T., Mizunoe Y., Kawabata S., Takade A., Harada M., Wai S.N., Yoshida S.
J. Bacteriol. 185:1010-1017(2003) [PubMed: 12533477] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-21, IRON BINDING, FUNCTION IN PROTECTION OF DNA FROM HYDROGEN PEROXIDE STRESS.
[2]"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences."
Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. expand/collapse author list , van Vliet A.H.M., Whitehead S., Barrell B.G.
Nature 403:665-668(2000) [PubMed: 10688204] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 11168 / Serotype O:2.

Cross-references

Sequence databases

AL111168 Genomic DNA. Translation: CAL35634.1.
PIRD81300.
RefSeqYP_002344906.1.

3D structure databases

HSSPHSSP built from PDB template 1JI4 based on UniProtKB P43313.
ModBaseSearch...

Protein-protein interaction databases

IntActQ0P891. 37 interactions.

PTM databases

PhosSiteQ0P891.

Genome annotation databases

GeneID905816.
GenomeReviewsGene locus Cj1534c in contig AL111168_GR.
KEGGcje:Cj1534c.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ0P891.
OMAQ0P891. LANTHHA.

Family and domain databases

InterProIPR002177. DPS_DNA_bd.
IPR008331. Ferritin_Dps.
IPR012347. Ferritin_rel.
[Graphical view]
Gene3DG3DSA:1.20.1260.10. Ferritin_rel. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFPIRSF005900. Dps. 1 hit.
PRINTSPR01346. HELNAPAPROT.
ProDomPD149803. DPS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameDPS_CAMJE
AccessionPrimary (citable) accession number: Q0P891
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: September 19, 2006
Last modified: June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents