Q0P891 (DPS_CAMJE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 41.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: DNA protection during starvation protein EC=1.16.-.- | ||||
| Gene names |
| ||||
| Organism | Campylobacter jejuni | ||||
| Taxonomic identifier | 197 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter |
Protein attributes
| Sequence length | 149 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction Probable. Does not bind DNA. Ref.1 |
| Catalytic activity | 2 Fe2+ + H2O2 + 2 H+ = 2 Fe3+ + 2 H2O. |
| Subunit structure | Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe3+ can be deposited By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Induction | Constitutively expressed. Not induced by hydrogen peroxide or by iron. |
| Sequence similarities | Belongs to the dps family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Iron storage |
| Cellular component | Cytoplasm |
| Ligand | Iron Metal-binding |
| Molecular function | Oxidoreductase |
| Technical term | 3D-structure Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological process | cellular iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW response to stressInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ferric iron binding Inferred from electronic annotation. Source: InterPro oxidoreductase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| fliY | Q0PC74 | 1 | EBI-1192444,EBI-1191111 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||
Molecule processing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 149 | 149 | DNA protection during starvation protein | PRO_0000253339 | |||||||||||||||
Sites | |||||||||||||||||||
| Metal binding | 25 | 1 | Iron 1; shared with dodecameric partner By similarity | ||||||||||||||||
| Metal binding | 52 | 1 | Iron 1 By similarity | ||||||||||||||||
| Metal binding | 56 | 1 | Iron 1 By similarity | ||||||||||||||||
| Metal binding | 56 | 1 | Iron 2 By similarity | ||||||||||||||||
Secondary structure | |||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||
| Helix | 3 – 27 | 25 | |||||||||||||||||
| Helix | 33 – 60 | 28 | |||||||||||||||||
| Helix | 69 – 75 | 7 | |||||||||||||||||
| Helix | 88 – 115 | 28 | |||||||||||||||||
| Helix | 119 – 138 | 20 | |||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The iron-binding protein Dps confers hydrogen peroxide stress resistance to Campylobacter jejuni." Ishikawa T., Mizunoe Y., Kawabata S., Takade A., Harada M., Wai S.N., Yoshida S. J. Bacteriol. 185:1010-1017(2003) [PubMed: 12533477] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-21, IRON BINDING, FUNCTION IN PROTECTION OF DNA FROM HYDROGEN PEROXIDE STRESS. |
| [2] | "The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. Barrell B.G.Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AL111168 Genomic DNA. Translation: CAL35634.1. | ||||||||||||
| PIR | D81300. | ||||||||||||
| RefSeq | YP_002344906.1. NC_002163.1. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | Q0P891. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q0P891. 37 interactions. | ||||||||||||
PTM databases | |||||||||||||
| PhosSite | Q0P891. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| GeneID | 905816. | ||||||||||||
| GenomeReviews | Gene locus Cj1534c in contig AL111168_GR. | ||||||||||||
| KEGG | cje:Cj1534c. | ||||||||||||
| PATRIC | 20060028. VBICamJej33762_1511. | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | HBG672882. | ||||||||||||
| OMA | NESAEQM. | ||||||||||||
| PhylomeDB | Q0P891. | ||||||||||||
| ProtClustDB | CLSK2767721. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BioCyc | CJEJ192222:CJ1534C-MONOMER. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR002177. DPS_DNA-bd. IPR012347. Ferritin-rel. IPR009078. Ferritin/RR-like. IPR008331. Ferritin_DPS_dom. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:1.20.1260.10. Ferritin_rel. 1 hit. | ||||||||||||
| KO | K04047. | ||||||||||||
| Pfam | PF00210. Ferritin. 1 hit. [Graphical view] | ||||||||||||
| PIRSF | PIRSF005900. Dps. 1 hit. | ||||||||||||
| PRINTS | PR01346. HELNAPAPROT. | ||||||||||||
| SUPFAM | SSF47240. Ferritin/RR_like. 1 hit. | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Entry information
| Entry name | DPS_CAMJE | ||||||||
| Accession | Primary (citable) accession number: Q0P891 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with