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Protein

Transketolase

Gene

tkt

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.UniRule annotation

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei67Thiamine pyrophosphateCombined sources1
Metal bindingi152CalciumCombined sources1
Metal bindingi152MagnesiumCombined sources1
Metal bindingi182CalciumCombined sources1
Metal bindingi182MagnesiumCombined sources1
Metal bindingi184Calcium; via carbonyl oxygenCombined sources1
Metal bindingi184Magnesium; via carbonyl oxygenCombined sources1
Binding sitei256Thiamine pyrophosphateCombined sources1
Binding sitei391Thiamine pyrophosphateCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotationImported
LigandCalciumUniRule annotationCombined sources, MagnesiumUniRule annotationCombined sourcesSAAS annotation, Metal-bindingUniRule annotationCombined sourcesSAAS annotation, Thiamine pyrophosphateUniRule annotationCombined sourcesSAAS annotation

Enzyme and pathway databases

BioCyciCJEJ192222:G1G1F-1601-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
TransketolaseUniRule annotation (EC:2.2.1.1UniRule annotation)
Gene namesi
Name:tktImported
Ordered Locus Names:Cj1645Imported
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)Imported
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PaxDbiQ0P7Y3
PRIDEiQ0P7Y3

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ0P7Y3, 10 interactors
STRINGi192222.Cj1645

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L84X-ray1.36A1-632[»]
3M34X-ray1.65A1-632[»]
3M6LX-ray1.59A1-632[»]
3M7IX-ray1.75A1-632[»]
ProteinModelPortaliQ0P7Y3
SMRiQ0P7Y3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ0P7Y3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 34TRANSKETOLASE_1InterPro annotationAdd BLAST21

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni114 – 116Thiamine pyrophosphate bindingCombined sources3
Regioni152 – 153Thiamine pyrophosphate bindingCombined sources2
Regioni182 – 184Thiamine pyrophosphate bindingCombined sources3
Regioni417 – 420Thiamine pyrophosphate bindingCombined sources4

Sequence similaritiesi

Belongs to the transketolase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CV1 Bacteria
COG0021 LUCA
HOGENOMiHOG000225954
KOiK00615
OMAiFADYMRG

Family and domain databases

Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR005478 Transketolase_bac-like
IPR020826 Transketolase_BS
IPR033248 Transketolase_C
IPR033247 Transketolase_fam
IPR005474 Transketolase_N
PANTHERiPTHR43522 PTHR43522, 1 hit
PfamiView protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
PF00456 Transketolase_N, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
TIGRFAMsiTIGR00232 tktlase_bact, 1 hit
PROSITEiView protein in PROSITE
PS00801 TRANSKETOLASE_1, 1 hit
PS00802 TRANSKETOLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q0P7Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIQILQEQA NTLRFLSADM VQKANSGHPG APLGLADILS VLSYHLKHNP
60 70 80 90 100
KNPTWLNRDR LVFSGGHASA LLYSFLHLSG YDLSLEDLKN FRQLHSKTPG
110 120 130 140 150
HPEISTLGVE IATGPLGQGV ANAVGFAMAA KKAQNLLGSD LIDHKIYCLC
160 170 180 190 200
GDGDLQEGIS YEACSLAGLH KLDNFILIYD SNNISIEGDV GLAFNENVKM
210 220 230 240 250
RFEAQGFEVL SINGHDYEEI NKALEQAKKS TKPCLIIAKT TIAKGAGELE
260 270 280 290 300
GSHKSHGAPL GEEVIKKAKE QAGFDPNISF HIPQASKIRF ESAVELGDLE
310 320 330 340 350
EAKWKDKLEK SAKKELLERL LNPDFNKIAY PDFKGKDLAT RDSNGEILNV
360 370 380 390 400
LAKNLEGFLG GSADLGPSNK TELHSMGDFV EGKNIHFGIR EHAMAAINNA
410 420 430 440 450
FARYGIFLPF SATFFIFSEY LKPAARIAAL MKIKHFFIFT HDSIGVGEDG
460 470 480 490 500
PTHQPIEQLS TFRAMPNFLT FRPADGVENV KAWQIALNAD IPSAFVLSRQ
510 520 530 540 550
KLKALNEPVF GDVKNGAYLL KESKEAKFTL LASGSEVWLC LESANELEKQ
560 570 580 590 600
GFACNVVSMP CFELFEKQDK AYQERLLKGE VIGVEAAHSN ELYKFCHKVY
610 620 630
GIESFGESGK DKDVFERFGF SVSKLVNFIL SK
Length:632
Mass (Da):69,636
Last modified:September 19, 2006 - v1
Checksum:iFE55D337D3638D9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA Translation: CAL35742.1
PIRiC81261
RefSeqiWP_002858130.1, NC_002163.1
YP_002345014.1, NC_002163.1

Genome annotation databases

EnsemblBacteriaiCAL35742; CAL35742; Cj1645
GeneIDi905918
KEGGicje:Cj1645
PATRICifig|192222.6.peg.1621

Similar proteinsi

Entry informationi

Entry nameiQ0P7Y3_CAMJE
AccessioniPrimary (citable) accession number: Q0P7Y3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 19, 2006
Last sequence update: September 19, 2006
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

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