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RNA polymerase sigma factor



Escherichia coli
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli


GO - Molecular functioni

GO - Biological processi


Molecular functionDNA-bindingUniRule annotationSAAS annotation, Sigma factorUniRule annotationSAAS annotation
Biological processStress responseImported, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factorUniRule annotation
Gene namesi
ORF Names:A4T40_18155Imported, A5958_17365Imported, A9R57_17160Imported, AA102_04795Imported, AC067_03255Imported, AC789_1c29100Imported, ACN77_09675Imported, ACN81_26190Imported, ACU57_10240Imported, ACU90_25285Imported, AKG99_13645Imported, AM266_09255Imported, AM270_07330Imported, AMK83_11460Imported, AML07_15800Imported, AML35_26195Imported, APT94_11835Imported, APU18_00100Imported, APZ14_05385Imported, ARC77_09170Imported, AU473_09090Imported, AUQ13_13335Imported, AUS26_21785Imported, AW059_05705Imported, AW106_11200Imported, AWP75_06380Imported, B1K96_17520Imported, BE932_10670Imported, BE957_09800Imported, BE963_28680Imported, BHF46_00095Imported, BHS81_15700Imported, BHS87_14575Imported, BJJ90_06390Imported, BK248_16470Imported, BK292_20880Imported, BK334_05125Imported, BK373_05685Imported, BK375_01110Imported, BK383_23075Imported, BK400_09265Imported, BMT49_16405Imported, BMT53_22540Imported, BMT91_21695Imported, BMT94_06835Imported, BMT97_20115Imported, BN17_18601Imported, BUE81_07875Imported, BUE82_05635Imported, BW690_11020Imported, BWP17_16790Imported, BXT93_10515Imported, CA268_22720Imported, CA270_09035Imported, CA593_13930Imported, EC3234A_44c01800Imported, ECONIH1_14995Imported, ECs3439Imported, EL75_1074Imported, EL79_1085Imported, EL80_1087Imported, ERS085365_01495Imported, ERS085366_02092Imported, ERS085374_00015Imported, ERS085383_04189Imported, ERS085386_03142Imported, ERS085404_01005Imported, ERS085406_03514Imported, ERS085411_03653Imported, ERS085416_03737Imported, ERS139211_00845Imported, ERS139235_04438Imported, ERS150873_01369Imported, ERS150876_00880Imported, FORC28_1378Imported, GJ11_16745Imported, GJ12_17065Imported, HMPREF3040_02703Imported, HW42_17610Imported, JD73_17235Imported, MJ49_18045Imported, MS6198_29060Imported, PGD_00662Imported, PU06_05530Imported, RG28_08990Imported, SK85_02829Imported, SM09_02737Imported, SY51_14730Imported, UC41_13475Imported, UN86_04925Imported, UN91_26310Imported, WM48_14020Imported, WQ89_05960Imported, WR15_00960Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
  • UP000044893 Componenti: Unassembled WGS sequence
  • UP000078545 Componenti: Chromosome
  • UP000192295 Componenti: Unassembled WGS sequence
  • UP000040932 Componenti: Unassembled WGS sequence
  • UP000193530 Componenti: Unassembled WGS sequence
  • UP000044381 Componenti: Unassembled WGS sequence
  • UP000030018 Componenti: Unassembled WGS sequence
  • UP000030000 Componenti: Unassembled WGS sequence
  • UP000065978 Componenti: Chromosome
  • UP000194247 Componenti: Unassembled WGS sequence
  • UP000038112 Componenti: Unassembled WGS sequence
  • UP000053450 Componenti: Unassembled WGS sequence
  • UP000188724 Componenti: Unassembled WGS sequence
  • UP000070045 Componenti: Unassembled WGS sequence
  • UP000037564 Componenti: Unassembled WGS sequence
  • UP000184379 Componenti: Chromosome
  • UP000177471 Componenti: Chromosome
  • UP000094504 Componenti: Chromosome
  • UP000051846 Componenti: Unassembled WGS sequence
  • UP000194285 Componenti: Unassembled WGS sequence
  • UP000193168 Componenti: Unassembled WGS sequence
  • UP000185913 Componenti: Unassembled WGS sequence
  • UP000040934 Componenti: Unassembled WGS sequence
  • UP000186715 Componenti: Unassembled WGS sequence
  • UP000070450 Componenti: Unassembled WGS sequence
  • UP000185961 Componenti: Unassembled WGS sequence
  • UP000185422 Componenti: Chromosome
  • UP000044469 Componenti: Unassembled WGS sequence
  • UP000036012 Componenti: Unassembled WGS sequence
  • UP000076106 Componenti: Unassembled WGS sequence
  • UP000037153 Componenti: Unassembled WGS sequence
  • UP000028651 Componenti: Unassembled WGS sequence
  • UP000186204 Componenti: Unassembled WGS sequence
  • UP000033371 Componenti: Unassembled WGS sequence
  • UP000186169 Componenti: Unassembled WGS sequence
  • UP000076266 Componenti: Chromosome
  • UP000188855 Componenti: Unassembled WGS sequence
  • UP000036728 Componenti: Unassembled WGS sequence
  • UP000031522 Componenti: Chromosome
  • UP000077539 Componenti: Unassembled WGS sequence
  • UP000029988 Componenti: Unassembled WGS sequence
  • UP000032290 Componenti: Chromosome
  • UP000054864 Componenti: Unassembled WGS sequence
  • UP000077380 Componenti: Unassembled WGS sequence
  • UP000036812 Componenti: Unassembled WGS sequence
  • UP000030790 Componenti: Chromosome
  • UP000188999 Componenti: Unassembled WGS sequence
  • UP000186275 Componenti: Unassembled WGS sequence
  • UP000030834 Componenti: Unassembled WGS sequence
  • UP000194331 Componenti: Chromosome
  • UP000095493 Componenti: Unassembled WGS sequence
  • UP000045242 Componenti: Unassembled WGS sequence
  • UP000185501 Componenti: Chromosome
  • UP000184168 Componenti: Unassembled WGS sequence
  • UP000054277 Componenti: Unassembled WGS sequence
  • UP000194311 Componenti: Chromosome
  • UP000184369 Componenti: Unassembled WGS sequence
  • UP000194319 Componenti: Unassembled WGS sequence
  • UP000188758 Componenti: Unassembled WGS sequence
  • UP000030317 Componenti: Chromosome
  • UP000036405 Componenti: Unassembled WGS sequence
  • UP000076262 Componenti: Unassembled WGS sequence
  • UP000092652 Componenti: Chromosome
  • UP000033592 Componenti: Unassembled WGS sequence
  • UP000050307 Componenti: Unassembled WGS sequence
  • UP000189070 Componenti: Unassembled WGS sequence
  • UP000184459 Componenti: Unassembled WGS sequence
  • UP000184277 Componenti: Unassembled WGS sequence
  • UP000094022 Componenti: Unassembled WGS sequence
  • UP000184336 Componenti: Unassembled WGS sequence
  • UP000094451 Componenti: Chromosome
  • UP000042305 Componenti: Unassembled WGS sequence
  • UP000189626 Componenti: Chromosome
  • UP000034530 Componenti: Chromosome
  • UP000043139 Componenti: Unassembled WGS sequence
  • UP000189671 Componenti: Chromosome
  • UP000184355 Componenti: Unassembled WGS sequence
  • UP000051850 Componenti: Unassembled WGS sequence
  • UP000042887 Componenti: Unassembled WGS sequence
  • UP000189664 Componenti: Chromosome
  • UP000092566 Componenti: Chromosome
  • UP000184178 Componenti: Unassembled WGS sequence
  • UP000050556 Componenti: Unassembled WGS sequence
  • UP000076304 Componenti: Unassembled WGS sequence
  • UP000095183 Componenti: Unassembled WGS sequence
  • UP000044658 Componenti: Unassembled WGS sequence
  • UP000194199 Componenti: Chromosome
  • UP000188967 Componenti: Unassembled WGS sequence
  • UP000041959 Componenti: Unassembled WGS sequence
  • UP000032456 Componenti: Unassembled WGS sequence
  • UP000070338 Componenti: Unassembled WGS sequence
  • UP000043018 Componenti: Unassembled WGS sequence


Protein-protein interaction databases



3D structure databases

Select the link destinations:
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 91Sigma70_r2InterPro annotationAdd BLAST67
Domaini129 – 180Sigma70_r4_2InterPro annotationAdd BLAST52

Sequence similaritiesi

Belongs to the sigma-70 factor family. ECF subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105EMN. Bacteria.
COG1595. LUCA.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR014284. RNA_pol_sigma-70_dom.
IPR000838. RNA_pol_sigma70_ECF_CS.
IPR007627. RNA_pol_sigma70_r2.
IPR013249. RNA_pol_sigma70_r4_t2.
IPR014286. RNA_pol_sigma70_RpoE.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF04542. Sigma70_r2. 1 hit.
PF08281. Sigma70_r4_2. 1 hit.
SUPFAMiSSF88659. SSF88659. 1 hit.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02939. RpoE_Sigma70. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEiView protein in PROSITE
PS01063. SIGMA70_ECF. 1 hit.


Sequence statusi: Complete.

Q0P6M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
60 70 80 90 100
110 120 130 140 150
160 170 180 190
Mass (Da):21,696
Last modified:September 19, 2006 - v1

Sequence databases

Select the link destinations:
Links Updated
AY616598 Genomic DNA. Translation: AAZ80065.1.
EU897165 Genomic DNA. Translation: ACI79721.1.
EU897166 Genomic DNA. Translation: ACI79722.1.
EU897167 Genomic DNA. Translation: ACI79723.1.
EU897168 Genomic DNA. Translation: ACI79724.1.
EU897169 Genomic DNA. Translation: ACI79725.1.
CP009859 Genomic DNA. Translation: AIX64462.1.
CP009104 Genomic DNA. Translation: AIZ83649.1.
CP010315 Genomic DNA. Translation: AJE57134.1.
CP010876 Genomic DNA. Translation: AJO84602.1.
CP011416 Genomic DNA. Translation: AKH23280.1.
CP013025 Genomic DNA. Translation: ALL89369.1.
CP015020 Genomic DNA. Translation: AMW42407.1.
CP014667 Genomic DNA. Translation: ANK33349.1.
CP015229 Genomic DNA. Translation: ANO90346.1.
CP015228 Genomic DNA. Translation: ANP19408.1.
CP012693 Genomic DNA. Translation: AOM44369.1.
CP015834 Genomic DNA. Translation: AOM70985.1.
CP017669 Genomic DNA. Translation: APA41029.1.
CP010122 Genomic DNA. Translation: APJ76397.1.
CP017631 Genomic DNA. Translation: APT01668.1.
CP018770 Genomic DNA. Translation: APT61472.1.
CP018948 Genomic DNA. Translation: AQV19441.1.
CP018957 Genomic DNA. Translation: AQV33252.1.
CP018991 Genomic DNA. Translation: AQV72893.1.
CP021175 Genomic DNA. Translation: ARR34116.1.
CP021202 Genomic DNA. Translation: ARR61984.1.
CP021207 Genomic DNA. Translation: ARR65022.1.
HE964769 Genomic DNA. Translation: CCJ45076.1.
HG976952 Genomic DNA. Translation: CDU37595.1.
CXZU01000001 Genomic DNA. Translation: CTR29219.1.
CYAQ01000010 Genomic DNA. Translation: CTS34529.1.
CYAV01000018 Genomic DNA. Translation: CTS87771.1.
CYBM01000016 Genomic DNA. Translation: CTT99489.1.
CYBJ01000030 Genomic DNA. Translation: CTT99552.1.
CYCH01000004 Genomic DNA. Translation: CTU71773.1.
CYBW01000020 Genomic DNA. Translation: CTU88514.1.
CYDH01000007 Genomic DNA. Translation: CTV28771.1.
CYCK01000028 Genomic DNA. Translation: CTW08041.1.
CYCX01000035 Genomic DNA. Translation: CTW57679.1.
CYEC01000032 Genomic DNA. Translation: CTY17777.1.
CYFX01000006 Genomic DNA. Translation: CTZ21397.1.
CYGC01000004 Genomic DNA. Translation: CTZ48004.1.
JPQG01000003 Genomic DNA. Translation: KFD75417.1.
JPKH01000009 Genomic DNA. Translation: KGM70933.1.
JPKL01000018 Genomic DNA. Translation: KGM83109.1.
JPMZ01000007 Genomic DNA. Translation: KGM84502.1.
JUDN01000027 Genomic DNA. Translation: KHJ21501.1.
JYEF01000051 Genomic DNA. Translation: KJH07250.1.
JZDU01000048 Genomic DNA. Translation: KJW36086.1.
JZDZ01000126 Genomic DNA. Translation: KJW44396.1.
LEUM01000017 Genomic DNA. Translation: KLX95874.1.
LEYN01000021 Genomic DNA. Translation: KME68869.1.
LGZN01000006 Genomic DNA. Translation: KNF72172.1.
LGZP01000006 Genomic DNA. Translation: KNF81631.1.
LHAT01000031 Genomic DNA. Translation: KNZ98567.1.
LFZI01000002 Genomic DNA. Translation: KOA36894.1.
LDYI01000079 Genomic DNA. Translation: KPO13042.1.
LECN01000165 Genomic DNA. Translation: KPO45518.1.
LIVE01000012 Genomic DNA. Translation: KQJ16368.1.
LIVI01000006 Genomic DNA. Translation: KQJ45025.1.
LMBK01000157 Genomic DNA. Translation: KST33690.1.
LNHR01000183 Genomic DNA. Translation: KSX86135.1.
LNIP01000012 Genomic DNA. Translation: KSZ20211.1.
LSNZ01000091 Genomic DNA. Translation: KXG98323.1.
LPXZ01000218 Genomic DNA. Translation: KXL57113.1.
LOOZ01000019 Genomic DNA. Translation: KXR90395.1.
LOFS01000158 Genomic DNA. Translation: KYR50978.1.
LOGT01000177 Genomic DNA. Translation: KYS86030.1.
LOCS01000122 Genomic DNA. Translation: KYV71100.1.
LCVH01000044 Genomic DNA. Translation: OAC43574.1.
LXPG01000002 Genomic DNA. Translation: OAJ88330.1.
LZEH01000232 Genomic DNA. Translation: OEI61275.1.
MIWY01000001 Genomic DNA. Translation: OEN37731.1.
MOFD01000032 Genomic DNA. Translation: OJK74151.1.
MOGU01000036 Genomic DNA. Translation: OJM89602.1.
MOIL01000006 Genomic DNA. Translation: OJP16151.1.
MOJX01000009 Genomic DNA. Translation: OJR05769.1.
MOKA01000001 Genomic DNA. Translation: OJR19985.1.
MOKI01000052 Genomic DNA. Translation: OJR51884.1.
MOKZ01000006 Genomic DNA. Translation: OJS90335.1.
MPGQ01000001 Genomic DNA. Translation: OKB79787.1.
MPGT01000001 Genomic DNA. Translation: OKB92075.1.
LGMU01000102 Genomic DNA. Translation: OKU13609.1.
LGMY01000291 Genomic DNA. Translation: OKU13647.1.
LRLE01000024 Genomic DNA. Translation: OKW22279.1.
MSEK01000053 Genomic DNA. Translation: OLR87822.1.
MTKH01000079 Genomic DNA. Translation: ONG29165.1.
MTPS01000155 Genomic DNA. Translation: ONG34977.1.
MTFS01000025 Genomic DNA. Translation: OOC78374.1.
MOZG01000006 Genomic DNA. Translation: OOJ08971.1.
MOZJ01000034 Genomic DNA. Translation: OOJ17129.1.
MPAF01000054 Genomic DNA. Translation: OOK24931.1.
NCRV01000002 Genomic DNA. Translation: ORD26258.1.
NAHY01000249 Genomic DNA. Translation: ORJ76148.1.
NAFT01000055 Genomic DNA. Translation: ORT02530.1.
NEME01000003 Genomic DNA. Translation: OTB40459.1.
NENZ01000018 Genomic DNA. Translation: OTE00640.1.
NBCM01000022 Genomic DNA. Translation: OTE91546.1.
RefSeqiWP_001295364.1. NZ_NEFU01000002.1.

Genome annotation databases

EnsemblBacteriaiAIX64462; AIX64462; ECONIH1_14995.
AIZ83649; AIZ83649; HW42_17610.
AJE57134; AJE57134; AC789_1c29100.
AJO84602; AJO84602; SY51_14730.
AKH23280; AKH23280; AA102_04795.
ALD24180; ALD24180; AN206_06935.
ALL89369; ALL89369; MJ49_18045.
ALZ67576; ALZ67576; AWH59_16115.
AMW42407; AMW42407; ARC77_09170.
AMX14860; AMX14860; A4X18_15855.
ANK33349; ANK33349; WM48_14020.
ANM83317; ANM83317; A8V37_12710.
ANO90346; ANO90346; GJ11_16745.
ANP19408; ANP19408; GJ12_17065.
AOM44369; AOM44369; FORC28_1378.
AOM70985; AOM70985; MS6198_29060.
AOT31733; AOT31733; FORC31_1268.
CDU37595; CDU37595; PGD_00662.
CTR29219; CTR29219; ERS085374_00015.
CTS34529; CTS34529; ERS085365_01495.
CTS87771; CTS87771; ERS085366_02092.
CTT99489; CTT99489; ERS085386_03142.
CTT99552; CTT99552; ERS085383_04189.
CTU71773; CTU71773; ERS085404_01005.
CTU88514; CTU88514; ERS085406_03514.
CTV28771; CTV28771; ERS139211_00845.
CTW08041; CTW08041; ERS085411_03653.
CTW57679; CTW57679; ERS085416_03737.
CTX54881; CTX54881; ERS139266_00015.
CTX84384; CTX84384; ERS139269_00015.
CTY17777; CTY17777; ERS139235_04438.
CTZ21397; CTZ21397; ERS150873_01369.
CTZ48004; CTZ48004; ERS150876_00880.
KFD75417; KFD75417; JD73_17235.
KGM70933; KGM70933; EL75_1074.
KGM83109; KGM83109; EL80_1087.
KGM84502; KGM84502; EL79_1085.
KHH07640; KHH07640; PU69_17775.
KHI36316; KHI36316; PU33_05105.
KHJ21501; KHJ21501; PU06_05530.
KIG81739; KIG81739; PU38_07870.
KIH02970; KIH02970; PU21_16955.
KIH33398; KIH33398; PD07_25345.
KIQ46719; KIQ46719; IY32_09680.
KJH07250; KJH07250; UC41_13475.
KJW36086; KJW36086; UN86_04925.
KJW44396; KJW44396; UN91_26310.
KLG79650; KLG79650; WR12_02660.
KLX58638; KLX58638; SK78_01708.
KLX82559; KLX82559; SK83_04660.
KLX95874; KLX95874; SK85_02829.
KME68869; KME68869; SM09_02737.
KNF72172; KNF72172; WR15_00960.
KNF81631; KNF81631; WQ89_05960.
KNY74216; KNY74216; AGA26_17015.
KNZ98567; KNZ98567; AKG99_13645.
KOA36894; KOA36894; AC067_03255.
KPO13042; KPO13042; ACU57_10240.
KPO36804; KPO36804; ACU81_16920.
KPO45518; KPO45518; ACU90_25285.
KQJ16368; KQJ16368; AM266_09255.
KQJ45025; KQJ45025; AM270_07330.
KST33690; KST33690; APZ14_05385.
KSX86135; KSX86135; APT94_11835.
KSZ20211; KSZ20211; APU18_00100.
KUU39830; KUU39830; AWF22_03055.
KXG88279; KXG88279; HMPREF3041_05500.
KXG98323; KXG98323; HMPREF3040_02703.
KXI02698; KXI02698; AXE68_09795.
KXL57113; KXL57113; AUS26_21785.
KXQ38919; KXQ38919; AUQ01_15035.
KYR50978; KYR50978; AML07_15800.
KYS86030; KYS86030; AML35_26195.
KYV71100; KYV71100; AMK83_11460.
KZJ56519; KZJ56519; AWG90_00980.
OAC43574; OAC43574; EC3234A_44c01800.
OAF39852; OAF39852; AXK33_17665.
OAJ88330; OAJ88330; A5958_17365.
OAO69201; OAO69201; OO96_10605.
OAO74733; OAO74733; OK10_06225.
OAS94927; OAS94927; A6I92_14115.
OCO38267; OCO38267; AN669_0220605.
OCS74096; OCS74096; BBZ52_13445.
ODA84782; ODA84782; A9D65_12215.
ODH24147; ODH24147; A6804_07535.
ODH29519; ODH29519; A6803_13735.
OEG67599; OEG67599; A7H95_21085.
OEI61275; OEI61275; A9R57_17160.
OEN37731; OEN37731; BHF46_00095.

Similar proteinsi

Entry informationi

Entry nameiQ0P6M2_ECOLX
AccessioniPrimary (citable) accession number: Q0P6M2
Secondary accession number(s): A0A0J3VU61
Entry historyiIntegrated into UniProtKB/TrEMBL: September 19, 2006
Last sequence update: September 19, 2006
Last modified: September 27, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)


Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported