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Protein

Transmembrane protein 62

Gene

TMEM62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 62
Gene namesi
Name:TMEM62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000137842.6
HGNCiHGNC:26269 TMEM62
neXtProtiNX_Q0P6H9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21
Transmembranei572 – 592HelicalSequence analysisAdd BLAST21
Transmembranei599 – 619HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137842
PharmGKBiPA142670775

Polymorphism and mutation databases

BioMutaiTMEM62
DMDMi126256322

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002541361 – 643Transmembrane protein 62Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi180N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi467N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi626N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ0P6H9
MaxQBiQ0P6H9
PaxDbiQ0P6H9
PeptideAtlasiQ0P6H9
PRIDEiQ0P6H9

PTM databases

iPTMnetiQ0P6H9
PhosphoSitePlusiQ0P6H9

Expressioni

Gene expression databases

BgeeiENSG00000137842
CleanExiHS_TMEM62
ExpressionAtlasiQ0P6H9 baseline and differential
GenevisibleiQ0P6H9 HS

Organism-specific databases

HPAiHPA044461
HPA062359

Interactioni

Protein-protein interaction databases

BioGridi1230757 interactors.
IntActiQ0P6H9 7 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ0P6H9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8X Eukaryota
ENOG410XNV4 LUCA
GeneTreeiENSGT00390000016216
HOGENOMiHOG000231771
HOVERGENiHBG079491
InParanoidiQ0P6H9
OMAiGPWFVGE
OrthoDBiEOG091G05HA
PhylomeDBiQ0P6H9
TreeFamiTF323442

Family and domain databases

Gene3Di3.60.21.101 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit

Sequencei

Sequence statusi: Complete.

Q0P6H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVLALRVV AGLAAAALVA MLLEHYGLAG QPSPLPRPAP PRRPHPAPGP
60 70 80 90 100
GDSNIFWGLQ ISDIHLSRFR DPGRAVDLEK FCSETIDIIQ PALVLATGDL
110 120 130 140 150
TDAKTKEQLG SRQHEVEWQT YQGILKKTRV MEKTKWLDIK GNHDAFNIPS
160 170 180 190 200
LDSIKNYYRK YSAVRRDGSF HYVHSTPFGN YSFICVDATV NPGPKRPYNF
210 220 230 240 250
FGILDKKKME ELLLLAKESS RSNHTIWFGH FTTSTILSPS PGIRSIMSSA
260 270 280 290 300
IAYLCGHLHT LGGLMPVLHT RHFQGTLELE VGDWKDNRRY RIFAFDHDLF
310 320 330 340 350
SFADLIFGKW PVVLITNPKS LLYSCGEHEP LERLLHSTHI RVLAFSLSSI
360 370 380 390 400
TSVTVKIDGV HLGQAVHVSG PIFVLKWNPR NYSSGTHNIE VIVQDSAGRS
410 420 430 440 450
KSVHHIFSVQ ENNHLSFDPL ASFILRTDHY IMARVLFVLI VLSQLTILII
460 470 480 490 500
FRYRGYPELK EPSGFINLTS FSLHVLSKIN IFYYSVLLLT LYTVLGPWFF
510 520 530 540 550
GEIIDGKFGC CFSFGIFVNG HFLQGSITFI IGILQLAFFN IPLMAYMCWS
560 570 580 590 600
LLQRCFGHNF RSHLHQRKYL KIMPVHLLML LLYIWQVYSC YFLYATYGTL
610 620 630 640
AFLFSPLRTW LTLLTPVLIR YVWTLNSTKF GIFMVQLKSH LSS
Length:643
Mass (Da):73,133
Last modified:September 19, 2006 - v1
Checksum:iE33D1C235DC33BC7
GO

Sequence cautioni

The sequence BAB15630 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti427T → A in BAB15630 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009981 mRNA Translation: AAH09981.2
AK027028 mRNA Translation: BAB15630.1 Different initiation.
CR457370 mRNA Translation: CAG33651.1
CCDSiCCDS32210.1
RefSeqiNP_079232.3, NM_024956.3
XP_011520375.1, XM_011522073.1
UniGeneiHs.511175

Genome annotation databases

EnsembliENST00000260403; ENSP00000260403; ENSG00000137842
GeneIDi80021
KEGGihsa:80021
UCSCiuc001zqr.4 human

Similar proteinsi

Entry informationi

Entry nameiTMM62_HUMAN
AccessioniPrimary (citable) accession number: Q0P6H9
Secondary accession number(s): Q6I9Y5, Q9H5J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 19, 2006
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome