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Protein

Transmembrane protein 62

Gene

TMEM62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 62
Gene namesi
Name:TMEM62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:26269. TMEM62.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21
Transmembranei572 – 592HelicalSequence analysisAdd BLAST21
Transmembranei599 – 619HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137842.
PharmGKBiPA142670775.

Polymorphism and mutation databases

BioMutaiTMEM62.
DMDMi126256322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002541361 – 643Transmembrane protein 62Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi180N-linked (GlcNAc...)1 Publication1
Glycosylationi467N-linked (GlcNAc...)Sequence analysis1
Glycosylationi626N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ0P6H9.
PaxDbiQ0P6H9.
PeptideAtlasiQ0P6H9.
PRIDEiQ0P6H9.

PTM databases

iPTMnetiQ0P6H9.
PhosphoSitePlusiQ0P6H9.

Expressioni

Gene expression databases

BgeeiENSG00000137842.
CleanExiHS_TMEM62.
ExpressionAtlasiQ0P6H9. baseline and differential.
GenevisibleiQ0P6H9. HS.

Organism-specific databases

HPAiHPA044461.
HPA062359.

Interactioni

Protein-protein interaction databases

BioGridi123075. 6 interactors.
IntActiQ0P6H9. 7 interactors.
STRINGi9606.ENSP00000260403.

Structurei

3D structure databases

ProteinModelPortaliQ0P6H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8X. Eukaryota.
ENOG410XNV4. LUCA.
GeneTreeiENSGT00390000016216.
HOGENOMiHOG000231771.
HOVERGENiHBG079491.
InParanoidiQ0P6H9.
OMAiCTALGPW.
OrthoDBiEOG091G05HA.
PhylomeDBiQ0P6H9.
TreeFamiTF323442.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0P6H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVLALRVV AGLAAAALVA MLLEHYGLAG QPSPLPRPAP PRRPHPAPGP
60 70 80 90 100
GDSNIFWGLQ ISDIHLSRFR DPGRAVDLEK FCSETIDIIQ PALVLATGDL
110 120 130 140 150
TDAKTKEQLG SRQHEVEWQT YQGILKKTRV MEKTKWLDIK GNHDAFNIPS
160 170 180 190 200
LDSIKNYYRK YSAVRRDGSF HYVHSTPFGN YSFICVDATV NPGPKRPYNF
210 220 230 240 250
FGILDKKKME ELLLLAKESS RSNHTIWFGH FTTSTILSPS PGIRSIMSSA
260 270 280 290 300
IAYLCGHLHT LGGLMPVLHT RHFQGTLELE VGDWKDNRRY RIFAFDHDLF
310 320 330 340 350
SFADLIFGKW PVVLITNPKS LLYSCGEHEP LERLLHSTHI RVLAFSLSSI
360 370 380 390 400
TSVTVKIDGV HLGQAVHVSG PIFVLKWNPR NYSSGTHNIE VIVQDSAGRS
410 420 430 440 450
KSVHHIFSVQ ENNHLSFDPL ASFILRTDHY IMARVLFVLI VLSQLTILII
460 470 480 490 500
FRYRGYPELK EPSGFINLTS FSLHVLSKIN IFYYSVLLLT LYTVLGPWFF
510 520 530 540 550
GEIIDGKFGC CFSFGIFVNG HFLQGSITFI IGILQLAFFN IPLMAYMCWS
560 570 580 590 600
LLQRCFGHNF RSHLHQRKYL KIMPVHLLML LLYIWQVYSC YFLYATYGTL
610 620 630 640
AFLFSPLRTW LTLLTPVLIR YVWTLNSTKF GIFMVQLKSH LSS
Length:643
Mass (Da):73,133
Last modified:September 19, 2006 - v1
Checksum:iE33D1C235DC33BC7
GO

Sequence cautioni

The sequence BAB15630 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti427T → A in BAB15630 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009981 mRNA. Translation: AAH09981.2.
AK027028 mRNA. Translation: BAB15630.1. Different initiation.
CR457370 mRNA. Translation: CAG33651.1.
CCDSiCCDS32210.1.
RefSeqiNP_079232.3. NM_024956.3.
XP_011520375.1. XM_011522073.1.
UniGeneiHs.511175.

Genome annotation databases

EnsembliENST00000260403; ENSP00000260403; ENSG00000137842.
GeneIDi80021.
KEGGihsa:80021.
UCSCiuc001zqr.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009981 mRNA. Translation: AAH09981.2.
AK027028 mRNA. Translation: BAB15630.1. Different initiation.
CR457370 mRNA. Translation: CAG33651.1.
CCDSiCCDS32210.1.
RefSeqiNP_079232.3. NM_024956.3.
XP_011520375.1. XM_011522073.1.
UniGeneiHs.511175.

3D structure databases

ProteinModelPortaliQ0P6H9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123075. 6 interactors.
IntActiQ0P6H9. 7 interactors.
STRINGi9606.ENSP00000260403.

PTM databases

iPTMnetiQ0P6H9.
PhosphoSitePlusiQ0P6H9.

Polymorphism and mutation databases

BioMutaiTMEM62.
DMDMi126256322.

Proteomic databases

MaxQBiQ0P6H9.
PaxDbiQ0P6H9.
PeptideAtlasiQ0P6H9.
PRIDEiQ0P6H9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260403; ENSP00000260403; ENSG00000137842.
GeneIDi80021.
KEGGihsa:80021.
UCSCiuc001zqr.4. human.

Organism-specific databases

CTDi80021.
GeneCardsiTMEM62.
HGNCiHGNC:26269. TMEM62.
HPAiHPA044461.
HPA062359.
neXtProtiNX_Q0P6H9.
OpenTargetsiENSG00000137842.
PharmGKBiPA142670775.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE8X. Eukaryota.
ENOG410XNV4. LUCA.
GeneTreeiENSGT00390000016216.
HOGENOMiHOG000231771.
HOVERGENiHBG079491.
InParanoidiQ0P6H9.
OMAiCTALGPW.
OrthoDBiEOG091G05HA.
PhylomeDBiQ0P6H9.
TreeFamiTF323442.

Miscellaneous databases

ChiTaRSiTMEM62. human.
GenomeRNAii80021.
PROiQ0P6H9.

Gene expression databases

BgeeiENSG00000137842.
CleanExiHS_TMEM62.
ExpressionAtlasiQ0P6H9. baseline and differential.
GenevisibleiQ0P6H9. HS.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTMM62_HUMAN
AccessioniPrimary (citable) accession number: Q0P6H9
Secondary accession number(s): Q6I9Y5, Q9H5J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 19, 2006
Last modified: November 30, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.