ID DIK1C_HUMAN Reviewed; 419 AA. AC Q0P6D2; DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot. DT 18-MAY-2010, sequence version 3. DT 24-JAN-2024, entry version 122. DE RecName: Full=Divergent protein kinase domain 1C {ECO:0000305}; DE AltName: Full=Protein FAM69C; GN Name=DIPK1C {ECO:0000312|HGNC:HGNC:31729}; Synonyms=C18orf51, FAM69C; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16177791; DOI=10.1038/nature03983; RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J., RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.; RT "DNA sequence and analysis of human chromosome 18."; RL Nature 437:551-555(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000250|UniProtKB:Q8BQT2}; Single-pass type II membrane protein CC {ECO:0000250|UniProtKB:Q8BQT2}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q0P6D2-1; Sequence=Displayed; CC Name=2; CC IsoId=Q0P6D2-2; Sequence=VSP_025146; CC -!- PTM: Among the many cysteines in the lumenal domain, most are probably CC involved in disulfide bonds. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the DIPK family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC009704; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC019628; AAH19628.1; -; mRNA. DR CCDS; CCDS42445.2; -. [Q0P6D2-1] DR RefSeq; NP_001037834.2; NM_001044369.2. [Q0P6D2-1] DR AlphaFoldDB; Q0P6D2; -. DR BioGRID; 125930; 1. DR IntAct; Q0P6D2; 1. DR STRING; 9606.ENSP00000344331; -. DR iPTMnet; Q0P6D2; -. DR PhosphoSitePlus; Q0P6D2; -. DR BioMuta; FAM69C; -. DR DMDM; 296439351; -. DR MassIVE; Q0P6D2; -. DR PaxDb; 9606-ENSP00000344331; -. DR PeptideAtlas; Q0P6D2; -. DR ProteomicsDB; 58776; -. [Q0P6D2-1] DR ProteomicsDB; 58777; -. [Q0P6D2-2] DR Antibodypedia; 62764; 7 antibodies from 7 providers. DR DNASU; 125704; -. DR Ensembl; ENST00000343998.8; ENSP00000344331.6; ENSG00000187773.9. [Q0P6D2-1] DR Ensembl; ENST00000400291.2; ENSP00000383148.2; ENSG00000187773.9. [Q0P6D2-2] DR GeneID; 125704; -. DR KEGG; hsa:125704; -. DR MANE-Select; ENST00000343998.8; ENSP00000344331.6; NM_001044369.3; NP_001037834.2. DR UCSC; uc002llk.4; human. [Q0P6D2-1] DR AGR; HGNC:31729; -. DR CTD; 125704; -. DR GeneCards; DIPK1C; -. DR HGNC; HGNC:31729; DIPK1C. DR HPA; ENSG00000187773; Tissue enhanced (brain, retina). DR MIM; 614544; gene. DR neXtProt; NX_Q0P6D2; -. DR OpenTargets; ENSG00000187773; -. DR PharmGKB; PA165428999; -. DR VEuPathDB; HostDB:ENSG00000187773; -. DR eggNOG; ENOG502QSPC; Eukaryota. DR GeneTree; ENSGT00390000006452; -. DR HOGENOM; CLU_042490_0_0_1; -. DR InParanoid; Q0P6D2; -. DR OMA; CGPYYAT; -. DR OrthoDB; 2968643at2759; -. DR PhylomeDB; Q0P6D2; -. DR TreeFam; TF313319; -. DR PathwayCommons; Q0P6D2; -. DR SignaLink; Q0P6D2; -. DR BioGRID-ORCS; 125704; 9 hits in 1139 CRISPR screens. DR ChiTaRS; DIPK1C; human. DR GenomeRNAi; 125704; -. DR Pharos; Q0P6D2; Tdark. DR PRO; PR:Q0P6D2; -. DR Proteomes; UP000005640; Chromosome 18. DR RNAct; Q0P6D2; Protein. DR Bgee; ENSG00000187773; Expressed in ventricular zone and 112 other cell types or tissues. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR InterPro; IPR022049; FAM69_kinase_dom. DR InterPro; IPR029244; FAM69_N. DR InterPro; IPR011009; Kinase-like_dom_sf. DR PANTHER; PTHR21093:SF2; DIVERGENT PROTEIN KINASE DOMAIN 1C; 1. DR PANTHER; PTHR21093; UNCHARACTERIZED; 1. DR Pfam; PF12260; PIP49_C; 1. DR Pfam; PF14875; PIP49_N; 1. DR SMART; SM01299; PIP49_N; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR Genevisible; Q0P6D2; HS. PE 2: Evidence at transcript level; KW Alternative splicing; Disulfide bond; Endoplasmic reticulum; Membrane; KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. FT CHAIN 1..419 FT /note="Divergent protein kinase domain 1C" FT /id="PRO_0000286707" FT TOPO_DOM 1..22 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 23..43 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 44..419 FT /note="Lumenal" FT /evidence="ECO:0000255" FT MOTIF 16..17 FT /note="May mediate ER retention" FT /evidence="ECO:0000250" FT VAR_SEQ 1..299 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_025146" SQ SEQUENCE 419 AA; 46420 MW; 320959B6D70EA7DF CRC64; MARAAGARGP AGWCRRRGRC GRGTLLAFAA WTAGWVLAAA LLLRAHPGVL SERCTDEKSR RILAALCQDY QGGTLAGDLC EDLCVAGELL FQRCLHYNRG KKVLQADWRG RPVVLKSKEE AFSSFPPLSL LEEEAGEGGQ DMPEAELLLM VAGEVKSALG LELSNSSLGP WWPGRRGPRW RGQLASLWAL LQQEEYVYFS LLQDLSPHVL PVLGSCGHFY AVEFLAAGSP HHRALFPLDR APGAPGGGQA KAISDIALSF LDMVNHFDSD FSHRLHLCDI KPENFAIRSD FTVVAIDVDM AFFEPKMREI LEQNCTGDED CNFFDCFSRC DLRVNKCGAQ RVNNNLQVIC DKIFRHWFSA PLKSSAVSFQ LQLQLQEAVQ ECADPGVPSG NTRRAASSVF WKLRQLLQAT LRELQEAEK //