Reviewed, UniProtKB/Swiss-Prot Q0P6D2 (FA69C_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein FAM69C

Gene names

Name:	FAM69C
Synonyms:	C18orf51

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the FAM69 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q0P6D2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q0P6D2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-150: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Protein FAM69C		PRO_0000286707
Natural variations
	Alternative sequence	1 – 150	150	Missing in isoform 2.		VSP_025146

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 15, 2007. Version 2. Checksum: BA0BBB250201A1AB	FASTA	270	30,240
	10 20 30 40 50 60 MVAGEVKSAL GLELSNSSLG PWWPGRRGPR WRGQLASLWA LLQQEEYVYF SLLQDLSPHV 70 80 90 100 110 120 LPVLGSCGHF YAVEFLAAGS PHHRALFPLD RAPGAPGGGQ AKAISDIALS FLDMVNHFDS 130 140 150 160 170 180 DFSHRLHLCD IKPENFAIRS DFTVVAIDVD MAFFEPKMRE ILEQNCTGDE DCNFFDCFSR 190 200 210 220 230 240 CDLRVNKCGA QRVNNNLQVI CDKIFRHWFS APLKSSAVSF QLQLQLQEAV QECADPGVPS 250 260 270 GNTRRAASSV FWKLRQLLQA TLRELQEAEK
	Isoform 2. Checksum: 7723C3C9CAA09489	FASTA	120	13,791
	10 20 30 40 50 60 MAFFEPKMRE ILEQNCTGDE DCNFFDCFSR CDLRVNKCGA QRVNNNLQVI CDKIFRHWFS 70 80 90 100 110 120 APLKSSAVSF QLQLQLQEAV QECADPGVPS GNTRRAASSV FWKLRQLLQA TLRELQEAEK

References

[1]

"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed: 16177791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC009704 Genomic DNA. No translation available. BC019628 mRNA. Translation: AAH19628.1.
IPI	IPI00250724. IPI00845367.
UniGene	Hs.371690 Hs.681621
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q0P6D2.
Genome annotation databases
Ensembl	ENST00000343998; ENSP00000344331; ENSG00000187773; Homo sapiens. [Genome view]
UCSC	uc002llk.1. human. uc002lll.1. human.
Organism-specific databases
GeneCards	GC18M070253.
HGNC	HGNC:31729. FAM69C.
PharmGKB	PA134879018.
GenAtlas	Search...
Phylogenomic databases
OrthoDB	EOG93R65Z
Gene expression databases
ArrayExpress	Q0P6D2.
Bgee	Q0P6D2.
CleanEx	HS_C18orf51.
Genevestigator	Q0P6D2.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	81548.

Entry information

Entry name

FA69C_HUMAN

Accession

Primary (citable) accession number: Q0P6D2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	November 24, 2009
This is version 28 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.