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Q0P6D2 (FA69C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM69C
Gene names
Name:FAM69C
Synonyms:C18orf51
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.

Post-translational modification

Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds By similarity.

Sequence similarities

Belongs to the FAM69 family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q0P6D2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q0P6D2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-299: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419Protein FAM69C
PRO_0000286707

Regions

Topological domain1 – 2222Cytoplasmic Potential
Transmembrane23 – 4321Helical; Potential
Topological domain44 – 419376Lumenal Potential
Motif16 – 172May mediate ER retention By similarity

Natural variations

Alternative sequence1 – 299299Missing in isoform 2.
VSP_025146

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 320959B6D70EA7DF

FASTA41946,420
        10         20         30         40         50         60 
MARAAGARGP AGWCRRRGRC GRGTLLAFAA WTAGWVLAAA LLLRAHPGVL SERCTDEKSR 

        70         80         90        100        110        120 
RILAALCQDY QGGTLAGDLC EDLCVAGELL FQRCLHYNRG KKVLQADWRG RPVVLKSKEE 

       130        140        150        160        170        180 
AFSSFPPLSL LEEEAGEGGQ DMPEAELLLM VAGEVKSALG LELSNSSLGP WWPGRRGPRW 

       190        200        210        220        230        240 
RGQLASLWAL LQQEEYVYFS LLQDLSPHVL PVLGSCGHFY AVEFLAAGSP HHRALFPLDR 

       250        260        270        280        290        300 
APGAPGGGQA KAISDIALSF LDMVNHFDSD FSHRLHLCDI KPENFAIRSD FTVVAIDVDM 

       310        320        330        340        350        360 
AFFEPKMREI LEQNCTGDED CNFFDCFSRC DLRVNKCGAQ RVNNNLQVIC DKIFRHWFSA 

       370        380        390        400        410 
PLKSSAVSFQ LQLQLQEAVQ ECADPGVPSG NTRRAASSVF WKLRQLLQAT LRELQEAEK 

« Hide

Isoform 2 [UniParc].

Checksum: 7723C3C9CAA09489
Show »

FASTA12013,791

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC009704 Genomic DNA. No translation available.
BC019628 mRNA. Translation: AAH19628.1.
CCDSCCDS42445.2. [Q0P6D2-1]
RefSeqNP_001037834.2. NM_001044369.2. [Q0P6D2-1]
UniGeneHs.371690.

3D structure databases

ProteinModelPortalQ0P6D2.
SMRQ0P6D2. Positions 194-301.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM296439351.

Proteomic databases

PaxDbQ0P6D2.
PRIDEQ0P6D2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000343998; ENSP00000344331; ENSG00000187773. [Q0P6D2-1]
ENST00000400291; ENSP00000383148; ENSG00000187773. [Q0P6D2-2]
GeneID125704.
KEGGhsa:125704.
UCSCuc002llk.3. human. [Q0P6D2-1]

Organism-specific databases

CTD125704.
GeneCardsGC18M072102.
HGNCHGNC:31729. FAM69C.
HPAHPA048928.
MIM614544. gene.
neXtProtNX_Q0P6D2.
PharmGKBPA165428999.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG71854.
HOGENOMHOG000111953.
HOVERGENHBG094879.
InParanoidQ0P6D2.
OMACEDLCVA.
OrthoDBEOG779NZ7.
PhylomeDBQ0P6D2.
TreeFamTF313319.

Gene expression databases

BgeeQ0P6D2.
CleanExHS_C18orf51.
GenevestigatorQ0P6D2.

Family and domain databases

InterProIPR022049. FAM69_kinase_dom.
IPR029244. FAM69_N.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamPF12260. PIP49_C. 1 hit.
PF14875. PIP49_N. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi125704.
NextBio81548.
PROQ0P6D2.
SOURCESearch...

Entry information

Entry nameFA69C_HUMAN
AccessionPrimary (citable) accession number: Q0P6D2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM