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Protein

Sine oculis-binding protein homolog

Gene

Sobp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in development of the cochlea.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri142 – 18039FCS-type 1Sequence analysisAdd
BLAST
Zinc fingeri216 – 25641FCS-type 2Sequence analysisAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • SUMO polymer binding Source: UniProtKB

GO - Biological processi

  • cochlea development Source: HGNC
  • cognition Source: MGI
  • inner ear morphogenesis Source: MGI
  • locomotory behavior Source: MGI
  • sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sine oculis-binding protein homolog
Alternative name(s):
Jackson circler protein 1
Gene namesi
Name:SobpImported
Synonyms:Jxc1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1924427. Sobp.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: HGNC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Sine oculis-binding protein homologPRO_0000312233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei627 – 6271PhosphoserineCombined sources
Modified residuei694 – 6941PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ0P5V2.
PaxDbiQ0P5V2.
PRIDEiQ0P5V2.

PTM databases

iPTMnetiQ0P5V2.
PhosphoSiteiQ0P5V2.

Expressioni

Developmental stagei

Present at 14.5 dpc throughout the developing brain, with high expression in the cortical plate. During postnatal development, detected in all neurons, with an intense expression in the limbic system, with highest levels throughout layer V neurons in the cortex, the hippocampus, the pyriform cortex, the dorsomedial nucleus of the thalamus, the amygdala, and the hypothalamus. Cortical expression is strong throughout development, with no clear dorsoventral or rostrocaudal gradient, highest levels at P10 in layers II/III and V and in the subplate. Relatively strong expression in the mitral cells layer and anterior olfactory bulb, as well as in the Purkinje cell layer in the cerebellum. Expression in the limbic system postnatally corresponds to the time window of active synaptogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000038248.
CleanExiMM_SOBP.
ExpressionAtlasiQ0P5V2. baseline and differential.
GenevisibleiQ0P5V2. MM.

Interactioni

Subunit structurei

Interacts (via SIM domains) with SUMO1 and SUMO2.By similarity

GO - Molecular functioni

  • SUMO polymer binding Source: UniProtKB

Protein-protein interaction databases

BioGridi224598. 2 interactions.
STRINGi10090.ENSMUSP00000040072.

Structurei

3D structure databases

ProteinModelPortaliQ0P5V2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi618 – 6225SUMO interaction motif 1 (SIM); mediates the binding to polysumoylated substratesBy similarity
Motifi648 – 6525SUMO interaction motif 2 (SIM); mediates the binding to polysumoylated substratesBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi346 – 552207Pro-richSequence analysisAdd
BLAST
Compositional biasi695 – 74551Pro-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SOBP family.Sequence analysis
Contains 2 FCS-type zinc fingers.Sequence analysis

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri142 – 18039FCS-type 1Sequence analysisAdd
BLAST
Zinc fingeri216 – 25641FCS-type 2Sequence analysisAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEAE. Eukaryota.
ENOG4111QQS. LUCA.
GeneTreeiENSGT00730000111043.
HOGENOMiHOG000008673.
HOVERGENiHBG062766.
InParanoidiQ0P5V2.
OMAiEHGRSEV.
OrthoDBiEOG091G040K.
PhylomeDBiQ0P5V2.
TreeFamiTF324359.

Family and domain databases

InterProiIPR026092. RAI2/SOBP.
[Graphical view]
PANTHERiPTHR23186. PTHR23186. 2 hits.
PfamiPF15279. SOBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0P5V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEMEKEGRP PENKRSRKPA HPVKREINEE MKNFAENTMN ELLGWYGYDK
60 70 80 90 100
VELKDGEDIE FRSYTTDGES RQHISVLKEN SLPKPKLPED SVISSYNIST
110 120 130 140 150
GYSGLATGNG LSDSPAGSKD HGNVPIIVPL IPPPFIKPPA EDDVSNVQIM
160 170 180 190 200
CAWCQKVGIK RYSLSMGSEV KSFCSEKCFA ACRRAYFKRN KARDEDGRAE
210 220 230 240 250
TFPQQHYAKE TPRLAFKNNC ELLVCDWCKH IRHTKEYLDF GDGERRLQFC
260 270 280 290 300
SAKCLNQYKM DIFYKETQAN LPAGLCSTLH PHMESKAEGT GVQLLTPDSW
310 320 330 340 350
NIPLTDARRK APSPVTAAGQ SQGPGPSSST TVSPSDTANC SVTKIPTPVP
360 370 380 390 400
KSLPISETPS IPPVSVQPPA SIGPPLGVPP RSPPMVMTNR GPVPLPIFME
410 420 430 440 450
QQIIQQIRPP FIRGPPHHAS NPNSPLSNPM LPGIGAPPGG PRNLGPTSSP
460 470 480 490 500
MHRPMLSPHI HPPSTPTMPG NPPGLLPPPP PGAPLPSLPF PPVSMMPNGP
510 520 530 540 550
MPVPQMMNFG LPSLAPLVPP PTLLVPYPVI VPLPVPIPIP IPIPHVNDSK
560 570 580 590 600
PPNGFSSNGE SFVPSAPGDS SAAGGKAGGR SLSPRDSKQG SSKSADSPPG
610 620 630 640 650
SSGQALSLAP AERGRGEVVD LTRRAGSPAG AGGQPGFAGV LHGPQDGVID
660 670 680 690 700
LTVGHRARLH NVIHRALHAH VKAEREPGAA ERRTCGGCRD GHCSPPAAGD
710 720 730 740 750
PGPGAPAGPE AAAACNVIVN GTRSAPAEAK GAEPPPEQPP PPAPPKKLLS
760 770 780 790 800
SEEPVVNELE SVKENNCASN CHLDGEATKK LMGEEALAGG DKSDPNLNNP
810 820 830 840 850
ADEDHAYALR MLPKTGCVIQ PVPKPAEKAA MTPCVISSPM LSAGPEDLEP
860
PLKRRCLRIR NQNK
Length:864
Mass (Da):91,784
Last modified:September 19, 2006 - v1
Checksum:iDB06CB90A9F6FDB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ157775 mRNA. Translation: ABA39879.1.
BC059851 mRNA. Translation: AAH59851.1.
CCDSiCCDS35890.1.
RefSeqiNP_780616.4. NM_175407.3.
UniGeneiMm.153750.

Genome annotation databases

EnsembliENSMUST00000040275; ENSMUSP00000040072; ENSMUSG00000038248.
GeneIDi109205.
KEGGimmu:109205.
UCSCiuc007ezf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ157775 mRNA. Translation: ABA39879.1.
BC059851 mRNA. Translation: AAH59851.1.
CCDSiCCDS35890.1.
RefSeqiNP_780616.4. NM_175407.3.
UniGeneiMm.153750.

3D structure databases

ProteinModelPortaliQ0P5V2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224598. 2 interactions.
STRINGi10090.ENSMUSP00000040072.

PTM databases

iPTMnetiQ0P5V2.
PhosphoSiteiQ0P5V2.

Proteomic databases

MaxQBiQ0P5V2.
PaxDbiQ0P5V2.
PRIDEiQ0P5V2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040275; ENSMUSP00000040072; ENSMUSG00000038248.
GeneIDi109205.
KEGGimmu:109205.
UCSCiuc007ezf.1. mouse.

Organism-specific databases

CTDi55084.
MGIiMGI:1924427. Sobp.

Phylogenomic databases

eggNOGiENOG410IEAE. Eukaryota.
ENOG4111QQS. LUCA.
GeneTreeiENSGT00730000111043.
HOGENOMiHOG000008673.
HOVERGENiHBG062766.
InParanoidiQ0P5V2.
OMAiEHGRSEV.
OrthoDBiEOG091G040K.
PhylomeDBiQ0P5V2.
TreeFamiTF324359.

Miscellaneous databases

ChiTaRSiSobp. mouse.
PROiQ0P5V2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038248.
CleanExiMM_SOBP.
ExpressionAtlasiQ0P5V2. baseline and differential.
GenevisibleiQ0P5V2. MM.

Family and domain databases

InterProiIPR026092. RAI2/SOBP.
[Graphical view]
PANTHERiPTHR23186. PTHR23186. 2 hits.
PfamiPF15279. SOBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSOBP_MOUSE
AccessioniPrimary (citable) accession number: Q0P5V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 19, 2006
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.