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Protein

ADP-ribosylation factor-like protein 16

Gene

ARL16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378GTPBy similarity
Nucleotide bindingi82 – 865GTPBy similarity
Nucleotide bindingi139 – 1424GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 16
Gene namesi
Name:ARL16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:27902. ARL16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672583.

Polymorphism and mutation databases

BioMutaiARL16.
DMDMi119361248.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197ADP-ribosylation factor-like protein 16PRO_0000264630Add
BLAST

Proteomic databases

PaxDbiQ0P5N6.
PRIDEiQ0P5N6.

PTM databases

iPTMnetiQ0P5N6.
PhosphoSiteiQ0P5N6.

Expressioni

Gene expression databases

BgeeiQ0P5N6.
CleanExiHS_ARL16.
ExpressionAtlasiQ0P5N6. baseline and differential.
GenevisibleiQ0P5N6. HS.

Organism-specific databases

HPAiHPA043711.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AMPHP494183EBI-10186132,EBI-7121510
GOLGA2Q083793EBI-10186132,EBI-618309
PDE6DO439245EBI-10186132,EBI-712685

Protein-protein interaction databases

BioGridi130847. 3 interactions.
IntActiQ0P5N6. 3 interactions.
STRINGi9606.ENSP00000380635.

Structurei

3D structure databases

ProteinModelPortaliQ0P5N6.
SMRiQ0P5N6. Positions 27-195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0072. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00730000111327.
HOGENOMiHOG000006835.
HOVERGENiHBG104241.
InParanoidiQ0P5N6.
OMAiCHSLLFM.
OrthoDBiEOG7XDBHS.
PhylomeDBiQ0P5N6.
TreeFamiTF323823.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0P5N6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVAGGRALS RGAELRVPGG AKHGMCLLLG ATGVGKTLLV KRLQEVSSRD
60 70 80 90 100
GKGDLGEPPP TRPTVGTNLT DIVAQRKITI RELGGCMGPI WSSYYGNCRS
110 120 130 140 150
LLFVMDASDP TQLSASCVQL LGLLSAEQLA EASVLILFNK IDLPCYMSTE
160 170 180 190
EMKSLIRLPD IIACAKQNIT TAEISAREGT GLAGVLAWLQ ATHRAND
Length:197
Mass (Da):20,936
Last modified:September 19, 2006 - v1
Checksum:i678AE0CFE6159E7F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101S → R.
Corresponds to variant rs8066889 [ dbSNP | Ensembl ].
VAR_059129

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105078 mRNA. Translation: AAI05079.1.
BC105076 mRNA. Translation: AAI05077.1.
CCDSiCCDS45813.1.
RefSeqiNP_001035114.1. NM_001040025.1.
UniGeneiHs.658789.

Genome annotation databases

EnsembliENST00000397498; ENSP00000380635; ENSG00000214087.
ENST00000621051; ENSP00000480579; ENSG00000214087.
GeneIDi339231.
KEGGihsa:339231.
UCSCiuc002kbf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105078 mRNA. Translation: AAI05079.1.
BC105076 mRNA. Translation: AAI05077.1.
CCDSiCCDS45813.1.
RefSeqiNP_001035114.1. NM_001040025.1.
UniGeneiHs.658789.

3D structure databases

ProteinModelPortaliQ0P5N6.
SMRiQ0P5N6. Positions 27-195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130847. 3 interactions.
IntActiQ0P5N6. 3 interactions.
STRINGi9606.ENSP00000380635.

PTM databases

iPTMnetiQ0P5N6.
PhosphoSiteiQ0P5N6.

Polymorphism and mutation databases

BioMutaiARL16.
DMDMi119361248.

Proteomic databases

PaxDbiQ0P5N6.
PRIDEiQ0P5N6.

Protocols and materials databases

DNASUi339231.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397498; ENSP00000380635; ENSG00000214087.
ENST00000621051; ENSP00000480579; ENSG00000214087.
GeneIDi339231.
KEGGihsa:339231.
UCSCiuc002kbf.4. human.

Organism-specific databases

CTDi339231.
GeneCardsiARL16.
HGNCiHGNC:27902. ARL16.
HPAiHPA043711.
neXtProtiNX_Q0P5N6.
PharmGKBiPA142672583.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0072. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00730000111327.
HOGENOMiHOG000006835.
HOVERGENiHBG104241.
InParanoidiQ0P5N6.
OMAiCHSLLFM.
OrthoDBiEOG7XDBHS.
PhylomeDBiQ0P5N6.
TreeFamiTF323823.

Miscellaneous databases

ChiTaRSiARL16. human.
GenomeRNAii339231.
NextBioi97302.
PROiQ0P5N6.

Gene expression databases

BgeeiQ0P5N6.
CleanExiHS_ARL16.
ExpressionAtlasiQ0P5N6. baseline and differential.
GenevisibleiQ0P5N6. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiARL16_HUMAN
AccessioniPrimary (citable) accession number: Q0P5N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 19, 2006
Last modified: March 16, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.