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Protein

ADP-ribosylation factor-like protein 16

Gene

ARL16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37GTPBy similarity8
Nucleotide bindingi82 – 86GTPBy similarity5
Nucleotide bindingi139 – 142GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 16
Gene namesi
Name:ARL16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000214087.8.
HGNCiHGNC:27902. ARL16.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000214087.
PharmGKBiPA142672583.

Polymorphism and mutation databases

BioMutaiARL16.
DMDMi119361248.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002646301 – 197ADP-ribosylation factor-like protein 16Add BLAST197

Proteomic databases

EPDiQ0P5N6.
PaxDbiQ0P5N6.
PeptideAtlasiQ0P5N6.
PRIDEiQ0P5N6.

PTM databases

iPTMnetiQ0P5N6.
PhosphoSitePlusiQ0P5N6.

Expressioni

Gene expression databases

BgeeiENSG00000214087.
CleanExiHS_ARL16.
ExpressionAtlasiQ0P5N6. baseline and differential.
GenevisibleiQ0P5N6. HS.

Organism-specific databases

HPAiHPA043711.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi130847. 3 interactors.
IntActiQ0P5N6. 8 interactors.
STRINGi9606.ENSP00000380635.

Structurei

3D structure databases

ProteinModelPortaliQ0P5N6.
SMRiQ0P5N6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0072. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00730000111327.
HOGENOMiHOG000006835.
HOVERGENiHBG104241.
InParanoidiQ0P5N6.
OMAiCICLGPK.
OrthoDBiEOG091G0UNH.
PhylomeDBiQ0P5N6.
TreeFamiTF323823.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0P5N6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVAGGRALS RGAELRVPGG AKHGMCLLLG ATGVGKTLLV KRLQEVSSRD
60 70 80 90 100
GKGDLGEPPP TRPTVGTNLT DIVAQRKITI RELGGCMGPI WSSYYGNCRS
110 120 130 140 150
LLFVMDASDP TQLSASCVQL LGLLSAEQLA EASVLILFNK IDLPCYMSTE
160 170 180 190
EMKSLIRLPD IIACAKQNIT TAEISAREGT GLAGVLAWLQ ATHRAND
Length:197
Mass (Da):20,936
Last modified:September 19, 2006 - v1
Checksum:i678AE0CFE6159E7F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05912910S → R. Corresponds to variant dbSNP:rs8066889Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105078 mRNA. Translation: AAI05079.1.
BC105076 mRNA. Translation: AAI05077.1.
CCDSiCCDS45813.1.
RefSeqiNP_001035114.1. NM_001040025.2.
NP_001316537.1. NM_001329608.1.
UniGeneiHs.658789.

Genome annotation databases

EnsembliENST00000397498; ENSP00000380635; ENSG00000214087.
ENST00000621051; ENSP00000480579; ENSG00000214087.
GeneIDi339231.
KEGGihsa:339231.
UCSCiuc002kbf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARL16_HUMAN
AccessioniPrimary (citable) accession number: Q0P5N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 19, 2006
Last modified: September 27, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families