ID   MPPA_BOVIN              Reviewed;         525 AA.
AC   Q0P5M8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Mitochondrial-processing peptidase subunit alpha;
DE            EC=3.4.24.64;
DE   AltName: Full=Alpha-MPP;
DE   Flags: Precursor;
GN   Name=PMPCA;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cleaves presequences (transit peptides) from
CC       mitochondrial protein precursors (By similarity).
CC   -!- CATALYTIC ACTIVITY: Release of N-terminal transit peptides from
CC       precursor proteins imported into the mitochondrion, typically with
CC       Arg in position P2.
CC   -!- SUBUNIT: Heterodimer of alpha and beta subunits (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC   -!- CAUTION: Does not seem to have a protease activity as it lack the
CC       zinc-binding site.
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DR   EMBL; BC119849; AAI19850.1; -; mRNA.
DR   IPI; IPI00702889; -.
DR   RefSeq; NP_001070432.1; -.
DR   UniGene; Bt.1487; -.
DR   MEROPS; M16.971; -.
DR   MEROPS; M16.985; -.
DR   Ensembl; ENSBTAG00000001353; Bos taurus.
DR   GeneID; 767847; -.
DR   KEGG; bta:767847; -.
DR   HOVERGEN; Q0P5M8; -.
DR   OMA; Q0P5M8; YRGNTVG.
DR   BRENDA; 3.4.24.64; 251.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR011237; Pept_M16_core.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   Gene3D; G3DSA:3.30.830.10; Pept_M16_core; 2.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 1.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Metalloprotease; Mitochondrion; Protease; Transit peptide.
FT   TRANSIT       1     33       Mitochondrion.
FT   CHAIN        34    525       Mitochondrial-processing peptidase
FT                                subunit alpha.
FT                                /FTId=PRO_0000283040.
SQ   SEQUENCE   525 AA;  58135 MW;  9D375E3FA8B7E1C2 CRC64;
     MAAMVLAATR LLRGSGSWGR SRPRFGDPAY RRFSSGGAYP NIPLSSPLPG VPKPVFATVD
     GQEKFETKVT TLDNGLRVAS QNKFGQFCTV GILINSGSRY EAKYLSGIAH FLEKLAFSST
     ERFDSKDEIL LTLEKHGGIC DCQTSRDTTM YAVSADSKGL DTVVGLLADV VLHPRLTDEE
     IEMARMAVQF ELEDLNMRPD PEPLLTEMVH EAAYRENTVG LHRFCPAENV GKMDRDVLHA
     YLRNYYTPDR MVLAGVGVEH AQLVECARKY LLGTCPAWGT GAAVHVDRSV AQYTGGIVKL
     ERDMSNVSLG PTPFPELTHI MIGLESCSFL EGDFIPFAVL NMMMGGGGSF SAGGPGKGMF
     TRLYLNVLNR HHWMYNATSY HHSYEDTGLL CIHASADPRQ VREMVEIVTR EFVLMAGTVD
     VVELERAKTQ LTSMLMMNLE ARPVIFEDVG RQVLATRSRK LPHELCALIR DVKPEDIKRV
     ASKMLRGKPA VAALGDLSEL PAYEHVQAAL ASRDGRLPRV YRLFR
//