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Reviewed, UniProtKB/Swiss-Prot Q0P5M8 (MPPA_BOVIN)

Last modified June 16, 2009. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Mitochondrial-processing peptidase subunit alpha
    EC=3.4.24.64
Alternative name(s):
    Alpha-MPP
Gene names
Name: PMPCA
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length525 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Cleaves presequences (transit peptides) from mitochondrial protein precursors By similarity.

Catalytic activity

Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

Subunit structure

Heterodimer of alpha and beta subunits By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the peptidase M16 family.

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   Molecular functionHydrolase
Metalloprotease
Protease
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmetalloendopeptidase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3333Mitochondrion
Chain34 – 525492Mitochondrial-processing peptidase subunit alpha
PRO_0000283040

Sequences

Sequence LengthMass (Da)Tools
Q0P5M8-1 [UniParc].

Last modified September 19, 2006. Version 1.
Checksum: 9D375E3FA8B7E1C2

FASTA52558,135
        10         20         30         40         50         60 
MAAMVLAATR LLRGSGSWGR SRPRFGDPAY RRFSSGGAYP NIPLSSPLPG VPKPVFATVD 

        70         80         90        100        110        120 
GQEKFETKVT TLDNGLRVAS QNKFGQFCTV GILINSGSRY EAKYLSGIAH FLEKLAFSST 

       130        140        150        160        170        180 
ERFDSKDEIL LTLEKHGGIC DCQTSRDTTM YAVSADSKGL DTVVGLLADV VLHPRLTDEE 

       190        200        210        220        230        240 
IEMARMAVQF ELEDLNMRPD PEPLLTEMVH EAAYRENTVG LHRFCPAENV GKMDRDVLHA 

       250        260        270        280        290        300 
YLRNYYTPDR MVLAGVGVEH AQLVECARKY LLGTCPAWGT GAAVHVDRSV AQYTGGIVKL 

       310        320        330        340        350        360 
ERDMSNVSLG PTPFPELTHI MIGLESCSFL EGDFIPFAVL NMMMGGGGSF SAGGPGKGMF 

       370        380        390        400        410        420 
TRLYLNVLNR HHWMYNATSY HHSYEDTGLL CIHASADPRQ VREMVEIVTR EFVLMAGTVD 

       430        440        450        460        470        480 
VVELERAKTQ LTSMLMMNLE ARPVIFEDVG RQVLATRSRK LPHELCALIR DVKPEDIKRV 

       490        500        510        520 
ASKMLRGKPA VAALGDLSEL PAYEHVQAAL ASRDGRLPRV YRLFR 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thalamus.

Cross-references

Sequence databases

BC119849 mRNA. Translation: AAI19850.1.
IPIIPI00702889.
RefSeqNP_001070432.1.
UniGeneBt.1487

3D structure databases

ModBaseSearch...

Protein family/group databases

MEROPSM16.971.
M16.985.

Genome annotation databases

EnsemblENSBTAG00000001353. Bos taurus. [Contig view]
GeneID767847.
KEGGbta:767847.

Phylogenomic databases

HOVERGENQ0P5M8.
OMAQ0P5M8. YRGNTVG.

Enzyme and pathway databases

BRENDA3.4.24.64. 251.

Family and domain databases

InterProIPR011237. Pept_M16_core.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
[Graphical view]
Gene3DG3DSA:3.30.830.10. Pept_M16_core. 2 hits.
PfamPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
PROSITEPS00143. INSULINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPPA_BOVIN
AccessionPrimary (citable) accession number: Q0P5M8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 19, 2006
Last modified: June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents