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Protein

Sulfatase-modifying factor 1

Gene

SUMF1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE (By similarity).By similarity

Miscellaneous

The resulting 3-oxoalanine in the substrate protein is called C(alpha)-formylglycine by many authors. It should not be confused with N-formylglycine.

Catalytic activityi

A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O.

Pathwayi: sulfatase oxidation

This protein is involved in the pathway sulfatase oxidation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway sulfatase oxidation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130Calcium 2By similarity1
Metal bindingi259Calcium 1By similarity1
Metal bindingi260Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi273Calcium 1By similarity1
Metal bindingi275Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi293Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi296Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi298Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi300Calcium 2By similarity1
Active sitei333Proton acceptorCurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-1660662 Glycosphingolipid metabolism
R-BTA-1663150 The activation of arylsulfatases
UniPathwayiUPA00910

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfatase-modifying factor 1 (EC:1.8.99.-)
Alternative name(s):
C-alpha-formylglycine-generating enzyme 1
Gene namesi
Name:SUMF1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Organism-specific databases

VGNCiVGNC:35471 SUMF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33By similarityAdd BLAST33
ChainiPRO_000033303434 – 374Sulfatase-modifying factor 1Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 52By similarity
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi218 ↔ 365By similarity
Disulfide bondi235 ↔ 346By similarity
Disulfide bondi336 ↔ 341Redox-activeBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ0P5L5
PRIDEiQ0P5L5

Expressioni

Gene expression databases

BgeeiENSBTAG00000039855

Interactioni

Subunit structurei

Monomer, homodimer and heterodimer with SUMF2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000052631

Structurei

3D structure databases

ProteinModelPortaliQ0P5L5
SMRiQ0P5L5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni341 – 360Interaction with sulfatasesBy similarityAdd BLAST20

Sequence similaritiesi

Belongs to the sulfatase-modifying factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEYZ Eukaryota
COG1262 LUCA
GeneTreeiENSGT00390000008983
HOGENOMiHOG000135466
HOVERGENiHBG054193
InParanoidiQ0P5L5
KOiK13444
OMAiKLFPWGN
OrthoDBiEOG091G0DD2
TreeFamiTF324027

Family and domain databases

InterProiView protein in InterPro
IPR016187 CTDL_fold
IPR005532 SUMF_dom
PfamiView protein in Pfam
PF03781 FGE-sulfatase, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0P5L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPALGPAR GCGAELTLVL LLSLFLLLGW AAGGEEAGPE AGAPSLVGSC
60 70 80 90 100
GCGNPQRPGA QGSSAAAHRY SREANAPGSV PGGRPSPPTK MVPIPAGVFT
110 120 130 140 150
MGTDDPQIKQ DGEAPARRVA IDAFYMDAYE VSNAEFEKFV NSTGYLTEAE
160 170 180 190 200
KFGDSFVFEG MLSEQVKSDI QQAVAAAPWW LPVKGANWRH PEGPDSTVLH
210 220 230 240 250
RPDHPVLHVS WNDAVAYCTW AGKRLPTEAE WEYSCRGGLQ NRLFPWGNKL
260 270 280 290 300
QPKGQHYANI WQGEFPVTNT GEDGFRGTAP VDAFPPNGYG LYNIVGNAWE
310 320 330 340 350
WTSDWWTVHH SAEETINPKG PPSGKDRVKK GGSYMCHKSY CYRYRCAARS
360 370
QNTPDSSASN LGFRCAADHL PTTG
Length:374
Mass (Da):40,342
Last modified:September 19, 2006 - v1
Checksum:i964E6D59A80DB2C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119885 mRNA Translation: AAI19886.1
RefSeqiNP_001069544.1, NM_001076076.1
UniGeneiBt.30055

Genome annotation databases

EnsembliENSBTAT00000055237; ENSBTAP00000052631; ENSBTAG00000039855
GeneIDi536435
KEGGibta:536435

Similar proteinsi

Entry informationi

Entry nameiSUMF1_BOVIN
AccessioniPrimary (citable) accession number: Q0P5L5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 19, 2006
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health