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Protein

TOX high mobility group box family member 4

Gene

TOX4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi223 – 29169HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TOX high mobility group box family member 4
Gene namesi
Name:TOX4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

  • Note: Associated with chromatin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619TOX high mobility group box family member 4PRO_0000364348Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei176 – 1761PhosphothreonineBy similarity
Modified residuei178 – 1781PhosphoserineBy similarity
Modified residuei182 – 1821PhosphoserineBy similarity
Modified residuei313 – 3131PhosphothreonineBy similarity
Modified residuei315 – 3151PhosphoserineBy similarity
Modified residuei548 – 5481PhosphoserineBy similarity
Modified residuei550 – 5501PhosphoserineBy similarity
Modified residuei558 – 5581PhosphoserineBy similarity
Modified residuei560 – 5601PhosphoserineBy similarity
Modified residuei565 – 5651PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0P5K4.

Interactioni

Subunit structurei

Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020149.

Structurei

3D structure databases

ProteinModelPortaliQ0P5K4.
SMRiQ0P5K4. Positions 219-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi213 – 2186Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi401 – 534134Gln/Pro-richAdd
BLAST
Compositional biasi426 – 4327Poly-Ala

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00560000076898.
HOGENOMiHOG000230949.
HOVERGENiHBG051013.
InParanoidiQ0P5K4.
OMAiPPTLKMQ.
OrthoDBiEOG7R834J.
TreeFamiTF106481.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0P5K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFPGGNDNY LTITGPSHPF LSGAETFHTP SLGDEEFEIP PISLDSDPSL
60 70 80 90 100
AVSDVVGHFD DLADPSSSQD GSFSAQYGVQ TLDMPVGMTH GLMEQGGGLL
110 120 130 140 150
SGGLTMDLDH SIGTQYSANP PVTIDVPMTD MTSGLMGHSQ LTTIDQSELS
160 170 180 190 200
SQLGLSLGGG TILPPAQSPE DRLSTTPSPT SSLHEDGVEE FRRQPPSQKT
210 220 230 240 250
VVVEAGKKQK APKKRKKKDP NEPQKPVSAY ALFFRDTQAA IKGQNPNATF
260 270 280 290 300
GEVSKIVASM WDSLGEEQKQ VYKRKTEAAK KEYLKALAAY KDNQECQATV
310 320 330 340 350
ETVDMDPAPP SQTPSPPPVA AADPASPAPA STEPPALSPS IVVNSTLSSY
360 370 380 390 400
VANQASSGAG GQPNITKLII TKQMLPSSIT MSQGGMVTVI PATVVTSRGL
410 420 430 440 450
QLGQTSTATI QPSQQAQIVT RSVLQAAAAA AASMQLPPPR LQPPPLQQMP
460 470 480 490 500
QPPTQQQVTI LQQPPPLQAM QQPPPQKFRI NLQQQPPPLQ VKIVPPPTLK
510 520 530 540 550
MQTTLVPPPV ESSPEQPVNN SPETHTVEET TPETICEMIT DVVPEVESPS
560 570 580 590 600
QMDVELVSGS PMTLSPQPRC VRSGCENPPV VSKDWDNEYC SNECVVKHCR
610
DVFLAWVASR NSNTVVFVK
Length:619
Mass (Da):66,087
Last modified:September 19, 2006 - v1
Checksum:iAB3B7D2EF6485295
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119929 mRNA. Translation: AAI19930.1.
RefSeqiNP_001069175.1. NM_001075707.1.
UniGeneiBt.51979.

Genome annotation databases

EnsembliENSBTAT00000020149; ENSBTAP00000020149; ENSBTAG00000015146.
GeneIDi515314.
KEGGibta:515314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119929 mRNA. Translation: AAI19930.1.
RefSeqiNP_001069175.1. NM_001075707.1.
UniGeneiBt.51979.

3D structure databases

ProteinModelPortaliQ0P5K4.
SMRiQ0P5K4. Positions 219-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020149.

Proteomic databases

PaxDbiQ0P5K4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020149; ENSBTAP00000020149; ENSBTAG00000015146.
GeneIDi515314.
KEGGibta:515314.

Organism-specific databases

CTDi9878.

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00560000076898.
HOGENOMiHOG000230949.
HOVERGENiHBG051013.
InParanoidiQ0P5K4.
OMAiPPTLKMQ.
OrthoDBiEOG7R834J.
TreeFamiTF106481.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal skin.

Entry informationi

Entry nameiTOX4_BOVIN
AccessioniPrimary (citable) accession number: Q0P5K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 19, 2006
Last modified: June 8, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.