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Protein

Regulation of nuclear pre-mRNA domain-containing protein 1A

Gene

RPRD1A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulation of nuclear pre-mRNA domain-containing protein 1A
Alternative name(s):
Cyclin-dependent kinase inhibitor 2B-related protein
p15INK4B-related protein
Gene namesi
Name:RPRD1A
Synonyms:P15RS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003113432 – 312Regulation of nuclear pre-mRNA domain-containing protein 1AAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei153PhosphoserineBy similarity1
Modified residuei156PhosphoserineBy similarity1
Modified residuei285PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ0P5J9.
PRIDEiQ0P5J9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000005497.

Interactioni

Subunit structurei

May form a heterodimer with RPRD1B. Associates with the RNA polymerase II subunit POLR2A (via CTD phosphorylated at 'Ser-2' and 'Ser-7' of the heptad repeats).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007226.

Structurei

3D structure databases

ProteinModelPortaliQ0P5J9.
SMRiQ0P5J9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 133CIDPROSITE-ProRule annotationAdd BLAST132

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili244 – 286Sequence analysisAdd BLAST43

Sequence similaritiesi

Belongs to the UPF0400 (RTT103) family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2669. Eukaryota.
ENOG410XRAP. LUCA.
GeneTreeiENSGT00400000022016.
HOGENOMiHOG000007456.
HOVERGENiHBG051177.
InParanoidiQ0P5J9.
OMAiAQWIMFH.
OrthoDBiEOG091G0F8X.
TreeFamiTF320926.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiView protein in InterPro
IPR006569. CID_dom.
IPR032337. CREPT.
IPR008942. ENTH_VHS.
IPR006903. RNA_pol_II-bd.
PfamiView protein in Pfam
PF16566. CREPT. 1 hit.
PF04818. CTD_bind. 1 hit.
SMARTiView protein in SMART
SM00582. RPR. 1 hit.
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiView protein in PROSITE
PS51391. CID. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0P5J9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAFSEAALE KKLSELSNSQ QSVQTLSLWL IHHRKHSRPI VTVWERELRK
60 70 80 90 100
AKPNRKLTFL YLANDVIQNS KRKGPEFTKD FAPVIVEAFK HVSSETDESC
110 120 130 140 150
KKHLGRVLSI WEERSVYEND VLEQLKQALY GDKKPRKRTY EQIKVDENEN
160 170 180 190 200
CSSLGSPSEP PQTLDLVRAL QDLENAASGD AAVHQRIASL PVEVQEVSLL
210 220 230 240 250
DKITDKESGE RLSKMVEDAC MLLADYNGRL AAEIDDRKQL TRMLADFLRC
260 270 280 290 300
QKEALAEKEH KLEEYKRKLA RVSLVRKELR SRIQSLPDLS RLPNVTGSHM
310
HLPFAGDIYS ED
Length:312
Mass (Da):35,720
Last modified:November 13, 2007 - v2
Checksum:i61785281F31CB328
GO
Isoform 2 (identifier: Q0P5J9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-270: EYKRKLA → VRNLFLI
     271-312: Missing.

Note: No experimental confirmation available.
Show »
Length:270
Mass (Da):30,913
Checksum:i5E6C5F6677BB30C8
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029529264 – 270EYKRKLA → VRNLFLI in isoform 2. 1 Publication7
Alternative sequenceiVSP_029530271 – 312Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119944 mRNA. Translation: AAI19945.1.
RefSeqiNP_001068624.1. NM_001075156.1. [Q0P5J9-2]
XP_005224014.1. XM_005223957.3. [Q0P5J9-1]
XP_010816978.1. XM_010818676.2. [Q0P5J9-1]
UniGeneiBt.74401.

Genome annotation databases

EnsembliENSBTAT00000007226; ENSBTAP00000007226; ENSBTAG00000005497. [Q0P5J9-1]
ENSBTAT00000056481; ENSBTAP00000048688; ENSBTAG00000005497. [Q0P5J9-2]
GeneIDi504355.
KEGGibta:504355.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRPR1A_BOVIN
AccessioniPrimary (citable) accession number: Q0P5J9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: June 7, 2017
This is version 70 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries