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Protein

4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Gene

HOGA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the final step in the metabolic pathway of hydroxyproline.By similarity

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

Enzyme regulationi

Inhibited by divalent cations.

Kineticsi

  1. KM=26 µM for DL-4-hydroxy-2-oxoglutarate1 Publication
  1. Vmax=10.7 µmol/min/mg enzyme1 Publication

pH dependencei

Optimum pH is 8.8.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei168Involved in proton transfer during cleavageBy similarity1
Active sitei196Schiff-base intermediate with substrateBy similarity1
Binding sitei198SubstrateBy similarity1
Binding sitei222Substrate; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandSchiff base

Enzyme and pathway databases

ReactomeiR-BTA-389661 Glyoxylate metabolism and glycine degradation
SABIO-RKiQ0P5I5

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC:4.1.3.16)
Alternative name(s):
Dihydrodipicolinate synthase-like
Short name:
DHDPS-like protein
Probable 2-keto-4-hydroxyglutarate aldolase
Short name:
Probable KHG-aldolase
Gene namesi
Name:HOGA1
Synonyms:DHDPSL
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 26

Organism-specific databases

VGNCiVGNC:29900 HOGA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25Mitochondrion1 PublicationAdd BLAST25
ChainiPRO_000027334526 – 3274-hydroxy-2-oxoglutarate aldolase, mitochondrialAdd BLAST302

Proteomic databases

PaxDbiQ0P5I5
PRIDEiQ0P5I5

Expressioni

Gene expression databases

BgeeiENSBTAG00000012721

Interactioni

Subunit structurei

Homotetramer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016909

Structurei

3D structure databases

ProteinModelPortaliQ0P5I5
SMRiQ0P5I5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni77 – 78Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the DapA family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IJ4Q Eukaryota
COG0329 LUCA
GeneTreeiENSGT00530000063604
HOVERGENiHBG081405
InParanoidiQ0P5I5
KOiK18123
OMAiGMDACVP
OrthoDBiEOG091G0C8O
TreeFamiTF324600

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002220 DapA-like
IPR020625 Schiff_base-form_aldolases_AS
PANTHERiPTHR12128 PTHR12128, 1 hit
PfamiView protein in Pfam
PF00701 DHDPS, 1 hit
PIRSFiPIRSF001365 DHDPS, 1 hit
PRINTSiPR00146 DHPICSNTHASE
SMARTiView protein in SMART
SM01130 DHDPS, 1 hit
PROSITEiView protein in PROSITE
PS00666 DHDPS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0P5I5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVPRVWSSV RLGLSRVLSR TLRGWPSGEG RGMDLSGIYP PVTTPFTATA
60 70 80 90 100
EVDYGKLEEN LHKLGTLPFR GFVVQGSNGE FPFLTSSERL EVVSRARQAL
110 120 130 140 150
PKDKLLLAGS GCESTQATVE MTVSMAQVGA DAAMVVTPCY YRGRMSSAAL
160 170 180 190 200
IHHYTKVADL SPVPVVLYSV PANTGLDLPV DAVVTLSQHP NIVGIKDSGG
210 220 230 240 250
DVTRIGLIVH KTRSQDFQVL AGSAGFLLAS YAIGAVGGVC ALANVLGSQV
260 270 280 290 300
CQLERLCLTG QWEDAQKLQH RLIEPNTAVT RRFGIPGLKK TMDWFGYYGG
310 320
PCRSPLQELS PAQEEALRLD FASNGWL
Length:327
Mass (Da):35,217
Last modified:September 19, 2006 - v1
Checksum:i153314DCD1F0D587
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti327L → F in ABH06334 (PubMed:16305752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT026547 mRNA Translation: ABH06334.1
BC119998 mRNA Translation: AAI19999.1
RefSeqiNP_001068705.1, NM_001075237.1
UniGeneiBt.54337

Genome annotation databases

EnsembliENSBTAT00000016909; ENSBTAP00000016909; ENSBTAG00000012721
GeneIDi506001
KEGGibta:506001

Similar proteinsi

Entry informationi

Entry nameiHOGA1_BOVIN
AccessioniPrimary (citable) accession number: Q0P5I5
Secondary accession number(s): Q0V7M3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: September 19, 2006
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health