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Protein

Interleukin-1 receptor-associated kinase-like 2

Gene

IRAK2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.By similarity

Caution

Asn-331 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei233ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi212 – 220ATPPROSITE-ProRule annotation9
Nucleotide bindingi333 – 336ATPPROSITE-ProRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-168638 NOD1/2 Signaling Pathway
R-BTA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-BTA-450302 activated TAK1 mediates p38 MAPK activation
R-BTA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-BTA-9020702 Interleukin-1 signaling
R-BTA-937042 IRAK2 mediated activation of TAK1 complex
R-BTA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-BTA-975155 MyD88 dependent cascade initiated on endosome
R-BTA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-associated kinase-like 2
Short name:
IRAK-2
Gene namesi
Name:IRAK2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Organism-specific databases

VGNCiVGNC:30266 IRAK2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002775591 – 621Interleukin-1 receptor-associated kinase-like 2Add BLAST621

Proteomic databases

PaxDbiQ0P5I2
PRIDEiQ0P5I2

Expressioni

Gene expression databases

BgeeiENSBTAG00000006193
ExpressionAtlasiQ0P5I2 baseline

Interactioni

Subunit structurei

Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008135

Structurei

3D structure databases

ProteinModelPortaliQ0P5I2
SMRiQ0P5I2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 94DeathAdd BLAST82
Domaini206 – 476Protein kinasePROSITE-ProRule annotationAdd BLAST271

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1187 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00530000063073
HOGENOMiHOG000113102
HOVERGENiHBG052145
InParanoidiQ0P5I2
KOiK04731
OMAiLSEWDWM
OrthoDBiEOG091G0YKT
TreeFamiTF328924

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR033611 IRAK2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PANTHERiPTHR24419:SF2 PTHR24419:SF2, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00069 Pkinase, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q0P5I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCYIYQLPS WVLDDLCRNM DTLSEWDWMQ FASYVITDLT QLRKIKSMER
60 70 80 90 100
AQGVSITREL LWWWGMRQAT VQQLLDLLCH LELYRAAQII LNWKPVLEVK
110 120 130 140 150
SSIPDFSDTV KPGKPLAASV RNTEDKQETG QPVRPPTFPG SGPAAVRVNL
160 170 180 190 200
PAPPEDASSS LKTNQTASAD SKDFSASIPK QETLSSLAGD DLFWSEVDVI
210 220 230 240 250
QATDNFNPSH KISEGTFADV YRGHKRGTPF IFKKLREMAC SGPGSVEKFF
260 270 280 290 300
QAEVQICRRC CHPNVLPLLG CCTGEQFYSL IYPYMANGSL QDRLQGQGGS
310 320 330 340 350
DPLPWPQRIS ICSGLLHAVE HLHSLEIIHG NVKSSNVLLD QNFTPKLAHS
360 370 380 390 400
MAHPCPVNRT SKYTMMKTHL FQASTAYLPE DFIRVGQLTK RVDIFSCGIV
410 420 430 440 450
LAEVLTGIPA MDNNRNPVYL KDLLLHEIPS STISLCSRKM GVEKEMAKEI
460 470 480 490 500
CQKYLEKRAG RLPEAHAEAL VMAACLCLRR RNASLAEVCS SVAAVEEQLR
510 520 530 540 550
GQETSLPCSG LSEGTGSSFN TPEETDDVDN SSFDGSYSMR AAPWAGATSS
560 570 580 590 600
PPLTADEEGM LLAGGAVEAD SSAEACAPPE PPQDATETSW KIEINEAKRK
610 620
LMENILLYKE EKLDSIELFG P
Length:621
Mass (Da):68,630
Last modified:September 19, 2006 - v1
Checksum:i8641DDD096BD993F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120001 mRNA Translation: AAI20002.1
RefSeqiNP_001069164.1, NM_001075696.2
UniGeneiBt.76138

Genome annotation databases

EnsembliENSBTAT00000008135; ENSBTAP00000008135; ENSBTAG00000006193
GeneIDi515034
KEGGibta:515034

Similar proteinsi

Entry informationi

Entry nameiIRAK2_BOVIN
AccessioniPrimary (citable) accession number: Q0P5I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: September 19, 2006
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health