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Protein

Interleukin-1 receptor-associated kinase-like 2

Gene

IRAK2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei233 – 2331ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi212 – 2209ATPPROSITE-ProRule annotation
Nucleotide bindingi333 – 3364ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-168638. NOD1/2 Signaling Pathway.
R-BTA-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-BTA-446652. Interleukin-1 signaling.
R-BTA-450302. activated TAK1 mediates p38 MAPK activation.
R-BTA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-BTA-937042. IRAK2 mediated activation of TAK1 complex.
R-BTA-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-BTA-975155. MyD88 dependent cascade initiated on endosome.
R-BTA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-associated kinase-like 2
Short name:
IRAK-2
Gene namesi
Name:IRAK2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621Interleukin-1 receptor-associated kinase-like 2PRO_0000277559Add
BLAST

Proteomic databases

PaxDbiQ0P5I2.
PRIDEiQ0P5I2.

Expressioni

Gene expression databases

ExpressionAtlasiQ0P5I2. baseline.

Interactioni

Subunit structurei

Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008135.

Structurei

3D structure databases

ProteinModelPortaliQ0P5I2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 9482DeathAdd
BLAST
Domaini206 – 476271Protein kinasePROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Contains 1 death domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1187. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00530000063073.
HOGENOMiHOG000113102.
HOVERGENiHBG052145.
InParanoidiQ0P5I2.
KOiK04731.
OMAiLSEWDWM.
OrthoDBiEOG747PHP.
TreeFamiTF328924.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR033611. IRAK2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PANTHERiPTHR24419:SF2. PTHR24419:SF2. 1 hit.
PfamiPF00531. Death. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0P5I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCYIYQLPS WVLDDLCRNM DTLSEWDWMQ FASYVITDLT QLRKIKSMER
60 70 80 90 100
AQGVSITREL LWWWGMRQAT VQQLLDLLCH LELYRAAQII LNWKPVLEVK
110 120 130 140 150
SSIPDFSDTV KPGKPLAASV RNTEDKQETG QPVRPPTFPG SGPAAVRVNL
160 170 180 190 200
PAPPEDASSS LKTNQTASAD SKDFSASIPK QETLSSLAGD DLFWSEVDVI
210 220 230 240 250
QATDNFNPSH KISEGTFADV YRGHKRGTPF IFKKLREMAC SGPGSVEKFF
260 270 280 290 300
QAEVQICRRC CHPNVLPLLG CCTGEQFYSL IYPYMANGSL QDRLQGQGGS
310 320 330 340 350
DPLPWPQRIS ICSGLLHAVE HLHSLEIIHG NVKSSNVLLD QNFTPKLAHS
360 370 380 390 400
MAHPCPVNRT SKYTMMKTHL FQASTAYLPE DFIRVGQLTK RVDIFSCGIV
410 420 430 440 450
LAEVLTGIPA MDNNRNPVYL KDLLLHEIPS STISLCSRKM GVEKEMAKEI
460 470 480 490 500
CQKYLEKRAG RLPEAHAEAL VMAACLCLRR RNASLAEVCS SVAAVEEQLR
510 520 530 540 550
GQETSLPCSG LSEGTGSSFN TPEETDDVDN SSFDGSYSMR AAPWAGATSS
560 570 580 590 600
PPLTADEEGM LLAGGAVEAD SSAEACAPPE PPQDATETSW KIEINEAKRK
610 620
LMENILLYKE EKLDSIELFG P
Length:621
Mass (Da):68,630
Last modified:September 19, 2006 - v1
Checksum:i8641DDD096BD993F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120001 mRNA. Translation: AAI20002.1.
RefSeqiNP_001069164.1. NM_001075696.2.
UniGeneiBt.76138.

Genome annotation databases

EnsembliENSBTAT00000008135; ENSBTAP00000008135; ENSBTAG00000006193.
GeneIDi515034.
KEGGibta:515034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120001 mRNA. Translation: AAI20002.1.
RefSeqiNP_001069164.1. NM_001075696.2.
UniGeneiBt.76138.

3D structure databases

ProteinModelPortaliQ0P5I2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008135.

Proteomic databases

PaxDbiQ0P5I2.
PRIDEiQ0P5I2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000008135; ENSBTAP00000008135; ENSBTAG00000006193.
GeneIDi515034.
KEGGibta:515034.

Organism-specific databases

CTDi3656.

Phylogenomic databases

eggNOGiKOG1187. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00530000063073.
HOGENOMiHOG000113102.
HOVERGENiHBG052145.
InParanoidiQ0P5I2.
KOiK04731.
OMAiLSEWDWM.
OrthoDBiEOG747PHP.
TreeFamiTF328924.

Enzyme and pathway databases

ReactomeiR-BTA-168638. NOD1/2 Signaling Pathway.
R-BTA-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-BTA-446652. Interleukin-1 signaling.
R-BTA-450302. activated TAK1 mediates p38 MAPK activation.
R-BTA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-BTA-937042. IRAK2 mediated activation of TAK1 complex.
R-BTA-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-BTA-975155. MyD88 dependent cascade initiated on endosome.
R-BTA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.

Gene expression databases

ExpressionAtlasiQ0P5I2. baseline.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR033611. IRAK2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PANTHERiPTHR24419:SF2. PTHR24419:SF2. 1 hit.
PfamiPF00531. Death. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal liver.

Entry informationi

Entry nameiIRAK2_BOVIN
AccessioniPrimary (citable) accession number: Q0P5I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: September 19, 2006
Last modified: July 6, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Asn-331 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.