Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-1 receptor-associated kinase-like 2

Gene

IRAK2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei233ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi212 – 220ATPPROSITE-ProRule annotation9
Nucleotide bindingi333 – 336ATPPROSITE-ProRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-168638. NOD1/2 Signaling Pathway.
R-BTA-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-BTA-446652. Interleukin-1 family signaling.
R-BTA-450302. activated TAK1 mediates p38 MAPK activation.
R-BTA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-BTA-937042. IRAK2 mediated activation of TAK1 complex.
R-BTA-937072. TRAF6 mediated induction of TAK1 complex.
R-BTA-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-BTA-975155. MyD88 dependent cascade initiated on endosome.
R-BTA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-associated kinase-like 2
Short name:
IRAK-2
Gene namesi
Name:IRAK2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002775591 – 621Interleukin-1 receptor-associated kinase-like 2Add BLAST621

Proteomic databases

PaxDbiQ0P5I2.
PRIDEiQ0P5I2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000006193.
ExpressionAtlasiQ0P5I2. baseline.

Interactioni

Subunit structurei

Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008135.

Structurei

3D structure databases

ProteinModelPortaliQ0P5I2.
SMRiQ0P5I2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 94DeathAdd BLAST82
Domaini206 – 476Protein kinasePROSITE-ProRule annotationAdd BLAST271

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1187. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00530000063073.
HOGENOMiHOG000113102.
HOVERGENiHBG052145.
InParanoidiQ0P5I2.
KOiK04731.
OMAiLSEWDWM.
OrthoDBiEOG091G0YKT.
TreeFamiTF328924.

Family and domain databases

InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR033611. IRAK2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
PANTHERiPTHR24419:SF30. PTHR24419:SF30. 1 hit.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF00069. Pkinase. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0P5I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCYIYQLPS WVLDDLCRNM DTLSEWDWMQ FASYVITDLT QLRKIKSMER
60 70 80 90 100
AQGVSITREL LWWWGMRQAT VQQLLDLLCH LELYRAAQII LNWKPVLEVK
110 120 130 140 150
SSIPDFSDTV KPGKPLAASV RNTEDKQETG QPVRPPTFPG SGPAAVRVNL
160 170 180 190 200
PAPPEDASSS LKTNQTASAD SKDFSASIPK QETLSSLAGD DLFWSEVDVI
210 220 230 240 250
QATDNFNPSH KISEGTFADV YRGHKRGTPF IFKKLREMAC SGPGSVEKFF
260 270 280 290 300
QAEVQICRRC CHPNVLPLLG CCTGEQFYSL IYPYMANGSL QDRLQGQGGS
310 320 330 340 350
DPLPWPQRIS ICSGLLHAVE HLHSLEIIHG NVKSSNVLLD QNFTPKLAHS
360 370 380 390 400
MAHPCPVNRT SKYTMMKTHL FQASTAYLPE DFIRVGQLTK RVDIFSCGIV
410 420 430 440 450
LAEVLTGIPA MDNNRNPVYL KDLLLHEIPS STISLCSRKM GVEKEMAKEI
460 470 480 490 500
CQKYLEKRAG RLPEAHAEAL VMAACLCLRR RNASLAEVCS SVAAVEEQLR
510 520 530 540 550
GQETSLPCSG LSEGTGSSFN TPEETDDVDN SSFDGSYSMR AAPWAGATSS
560 570 580 590 600
PPLTADEEGM LLAGGAVEAD SSAEACAPPE PPQDATETSW KIEINEAKRK
610 620
LMENILLYKE EKLDSIELFG P
Length:621
Mass (Da):68,630
Last modified:September 19, 2006 - v1
Checksum:i8641DDD096BD993F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120001 mRNA. Translation: AAI20002.1.
RefSeqiNP_001069164.1. NM_001075696.2.
UniGeneiBt.76138.

Genome annotation databases

EnsembliENSBTAT00000008135; ENSBTAP00000008135; ENSBTAG00000006193.
GeneIDi515034.
KEGGibta:515034.

Similar proteinsi

Entry informationi

Entry nameiIRAK2_BOVIN
AccessioniPrimary (citable) accession number: Q0P5I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: September 19, 2006
Last modified: September 27, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Asn-331 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families