Reviewed, UniProtKB/Swiss-Prot Q0P5H7 (SYRM_BOVIN)

Names and origin

Protein names

Recommended name:
    Probable arginyl-tRNA synthetase, mitochondrial
    EC=6.1.1.19
Alternative name(s):
    Arginine--tRNA ligase
      Short name=ArgRS
    Arginyl-tRNA synthetase-like

Gene names

Name:	RARS2
Synonyms:	RARSL

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	578 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 16	16	Mitochondrion Potential
	Chain	17 – 578	562	Probable arginyl-tRNA synthetase, mitochondrial		PRO_0000284070
Regions
	Motif	133 – 144	12	"HIGH" region

Sequences

	Sequence		Length	Mass (Da)
	Q0P5H7-1 [UniParc]. Last modified September 19, 2006. Version 1. Checksum: 1CFCBDCA6492CB42	FASTA	578	65,631
	10 20 30 40 50 60 MACGFRRSIA SQLSRVLDLP PENLIKSISA VPISRKEEVA DFQLSVDSLL ENNNDHSRPD 70 80 90 100 110 120 IQIQAMRLAE KLKCDTVVSE ISTGQGTVNF KINRELLTKT VLQQVIEDGS KYGLKSELFS 130 140 150 160 170 180 GLPKKRIVVE FSSPNVAKKF HVGHLRSTII GNFIANLKEA LGHQVTRINY LGDWGMQFGL 190 200 210 220 230 240 LGTGFQLFGY EEKLQSSPLQ HLFEVYVQVN KEAADDKNVA KSAHEFFQRL ELGDMQALAL 250 260 270 280 290 300 WQKFRDLSID EYMRIYQRLG VHFDEYSGES FYREKSQEVL KLLDSKGLLQ KTLKGTAVVD 310 320 330 340 350 360 LSGNGDPSSV CTVMRSDGTS LYATRDLAAA IDRMEKYNFD KMIYVTDKGQ KKHFQQVFQI 370 380 390 400 410 420 LQIMGYDWAE RCQHVPFGVV QGMKTRRGDV TFLEDVLNEI RLRMLQNMAS IKTTKELENP 430 440 450 460 470 480 EETAEQVGLA ALIIQDFRGF LLSDYQFSWD RVFQSRGDTG VFLQYTHARL HSLEETFGCG 490 500 510 520 530 540 YLNDFNTACL QEPQSVSILQ HLLRFDEVLY RSSQDLQPRH IVSYLLTLSH LAAVAHRTLH 550 560 570 VRNSPPEVAG ARLHLFRAVR SVLANGMKLL GITPVCRM

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal cerebellum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC120020 mRNA. Translation: AAI20021.1.
IPI	IPI00688080.
RefSeq	NP_001069346.1.
UniGene	Bt.16559
3D structure databases
SMR	Q0P5H7. Positions 5-578.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0P5H7.
Genome annotation databases
Ensembl	ENSBTAT00000022568; ENSBTAP00000022568; ENSBTAG00000016967; Bos taurus. [Genome view]
GeneID	525894.
KEGG	bta:525894.
Organism-specific databases
CTD	525894.
Phylogenomic databases
eggNOG	maNOG04182.
HOVERGEN	Q0P5H7.
PhylomeDB	Q0P5H7.
Enzyme and pathway databases
BRENDA	6.1.1.19. 251.
Family and domain databases
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ic. IPR015945. Arg-tRNA-synth_Ic_core. IPR005148. Arg-tRNA-synth_Ic_N. IPR008909. DALR_anticod_bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM00836. DALR_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYRM_BOVIN

Accession

Primary (citable) accession number: Q0P5H7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	September 19, 2006
Last modified:	February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)