Reviewed, UniProtKB/Swiss-Prot Q0P5G4 (KAT3_BOVIN)

Names and origin

Protein names

Recommended name:
    Kynurenine--oxoglutarate transaminase 3
    EC=2.6.1.7
Alternative name(s):
    Kynurenine--oxoglutarate transaminase III
    Kynurenine aminotransferase III
      Short name=KATIII
    Cysteine-S-conjugate beta-lyase 2
    EC=4.4.1.13

Gene names

Name:	CCBL2
Synonyms:	KAT3

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond By similarity.
Catalytic activity	L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. RS-CH(2)-CH(NH3+)COO- = RSH + NH3 + pyruvate.
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Lyase Transferase
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Inferred from electronic annotation. Source: InterPro cysteine-S-conjugate beta-lyase activity Inferred from electronic annotation. Source: EC kynurenine-oxoglutarate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Kynurenine--oxoglutarate transaminase 3		PRO_0000287703
Amino acid modifications
	Modified residue	280	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0P5G4-1 [UniParc]. Last modified September 19, 2006. Version 1. Checksum: E353F80DCD854BD6	FASTA	455	51,472
	10 20 30 40 50 60 MFLAWERLCT LSCRPKFLKT VWASKILGLS TSAKMSLRFK NAKRIEGLDS NIWIEFTKLA 70 80 90 100 110 120 ADPSVVNLGQ GLPDISPPVY VKEELSKIAA IDNLNQYTRG FGHPSLVKAL SCLYEKFYHN 130 140 150 160 170 180 KINPNEEILV TVGAYGSLFN AIQGLIDEGD EVIVIVPFFD CYESMVRMAG ATPVFVPLRC 190 200 210 220 230 240 KPVDGKKCSS SDWTLDPQEL ASKFNSKTKA IILNTPHNPL GKVYTKEELQ VIADLCIKYD 250 260 270 280 290 300 TLCISDEVYE WLVYTGNKHF KIATFPGMWE RTITIGSAGK TFSVTGWKLG WSIGPKHLIK 310 320 330 340 350 360 HLQTVQQNTV YTCATPLQEA LAQAFWIDIK RMDDPECYFN SLPKELEVKR DRMVHLLESV 370 380 390 400 410 420 GLKSIVPDGG YFIIADVSLL DVDLLDMKDS NEPYDYKFVK WMIKNKKLSA IPVSAFCNAE 430 440 450 TKSQFEKFVR FCFIKKDSTL DAAEEIIKAW SRQNS

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC120067 mRNA. Translation: AAI20068.1.
IPI	IPI00700507.
RefSeq	NP_001068838.1.
UniGene	Bt.40115
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000000505. Bos taurus. [Contig view]
GeneID	508712.
KEGG	bta:508712.
Phylogenomic databases
HOVERGEN	Q0P5G4.
OMA	Q0P5G4. LYEKFYQ.
Enzyme and pathway databases
BRENDA	2.6.1.7. 251. 4.4.1.13. 251.
Family and domain databases
InterPro	IPR001176. ACC_synthase. IPR004839. Aminotrans_I/II. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00753. ACCSYNTHASE.
ProtoNet	Search...

Entry information

Entry name

KAT3_BOVIN

Accession

Primary (citable) accession number: Q0P5G4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	September 19, 2006
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)