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Protein

Kynurenine--oxoglutarate transaminase 3

Gene

CCBL2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).By similarity

Catalytic activityi

L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
An L-cysteine-S-conjugate + H2O = RSH + NH3 + pyruvate.
L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531SubstrateBy similarity
Binding sitei71 – 711Substrate; via amide nitrogenBy similarity
Binding sitei218 – 2181SubstrateBy similarity
Binding sitei430 – 4301SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Lyase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine--oxoglutarate transaminase 3 (EC:2.6.1.7)
Alternative name(s):
Cysteine-S-conjugate beta-lyase 2 (EC:4.4.1.13)
Kynurenine aminotransferase III
Short name:
KATIII
Kynurenine--glyoxylate transaminase (EC:2.6.1.63)
Kynurenine--oxoglutarate transaminase III
Gene namesi
Name:CCBL2
Synonyms:KAT3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Kynurenine--oxoglutarate transaminase 3PRO_0000287703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei116 – 1161N6-acetyllysine; alternateBy similarity
Modified residuei116 – 1161N6-succinyllysine; alternateBy similarity
Modified residuei280 – 2801N6-(pyridoxal phosphate)lysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ0P5G4.
PRIDEiQ0P5G4.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000643.

Structurei

3D structure databases

ProteinModelPortaliQ0P5G4.
SMRiQ0P5G4. Positions 38-451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0257. Eukaryota.
COG0436. LUCA.
GeneTreeiENSGT00650000093238.
HOGENOMiHOG000223045.
HOVERGENiHBG008391.
InParanoidiQ0P5G4.
KOiK00816.
OMAiARKVHDF.
OrthoDBiEOG76DTSB.
TreeFamiTF352342.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0P5G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLAWERLCT LSCRPKFLKT VWASKILGLS TSAKMSLRFK NAKRIEGLDS
60 70 80 90 100
NIWIEFTKLA ADPSVVNLGQ GLPDISPPVY VKEELSKIAA IDNLNQYTRG
110 120 130 140 150
FGHPSLVKAL SCLYEKFYHN KINPNEEILV TVGAYGSLFN AIQGLIDEGD
160 170 180 190 200
EVIVIVPFFD CYESMVRMAG ATPVFVPLRC KPVDGKKCSS SDWTLDPQEL
210 220 230 240 250
ASKFNSKTKA IILNTPHNPL GKVYTKEELQ VIADLCIKYD TLCISDEVYE
260 270 280 290 300
WLVYTGNKHF KIATFPGMWE RTITIGSAGK TFSVTGWKLG WSIGPKHLIK
310 320 330 340 350
HLQTVQQNTV YTCATPLQEA LAQAFWIDIK RMDDPECYFN SLPKELEVKR
360 370 380 390 400
DRMVHLLESV GLKSIVPDGG YFIIADVSLL DVDLLDMKDS NEPYDYKFVK
410 420 430 440 450
WMIKNKKLSA IPVSAFCNAE TKSQFEKFVR FCFIKKDSTL DAAEEIIKAW

SRQNS
Length:455
Mass (Da):51,472
Last modified:September 19, 2006 - v1
Checksum:iE353F80DCD854BD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120067 mRNA. Translation: AAI20068.1.
RefSeqiNP_001068838.1. NM_001075370.1.
UniGeneiBt.40115.

Genome annotation databases

EnsembliENSBTAT00000000643; ENSBTAP00000000643; ENSBTAG00000000505.
GeneIDi508712.
KEGGibta:508712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120067 mRNA. Translation: AAI20068.1.
RefSeqiNP_001068838.1. NM_001075370.1.
UniGeneiBt.40115.

3D structure databases

ProteinModelPortaliQ0P5G4.
SMRiQ0P5G4. Positions 38-451.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000643.

Proteomic databases

PaxDbiQ0P5G4.
PRIDEiQ0P5G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000000643; ENSBTAP00000000643; ENSBTAG00000000505.
GeneIDi508712.
KEGGibta:508712.

Organism-specific databases

CTDi56267.

Phylogenomic databases

eggNOGiKOG0257. Eukaryota.
COG0436. LUCA.
GeneTreeiENSGT00650000093238.
HOGENOMiHOG000223045.
HOVERGENiHBG008391.
InParanoidiQ0P5G4.
KOiK00816.
OMAiARKVHDF.
OrthoDBiEOG76DTSB.
TreeFamiTF352342.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal liver.

Entry informationi

Entry nameiKAT3_BOVIN
AccessioniPrimary (citable) accession number: Q0P5G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: September 19, 2006
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.