Reviewed, UniProtKB/Swiss-Prot Q0P5F9 (AL8A1_BOVIN)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase family 8 member A1
    EC=1.2.1.-

Gene names

Name:

ALDH8A1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro) By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 487	487	Aldehyde dehydrogenase family 8 member A1		PRO_0000312953
Regions
	Nucleotide binding	231 – 236	6	NAD By similarity
Sites
	Active site	253	1	Proton acceptor By similarity
	Active site	287	1	Nucleophile By similarity
	Site	155	1	Transition state stabilizer By similarity
Experimental info
	Sequence conflict	47	1	I → V in ABM06132. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q0P5F9-1 [UniParc]. Last modified September 19, 2006. Version 1. Checksum: 3EC8B8DAB4AE5414	FASTA	487	53,363
	10 20 30 40 50 60 MAGRGGLLML ENFIGGKFLP CSSYLDSYDP STGEVYCHVP NSGKEEIEAA VEAARAAFPG 70 80 90 100 110 120 WSSRSPQERS QVLQRLADLL EQSLEELAQA ESKDQGKTIT LARTMDIPRA VHNFRFFASS 130 140 150 160 170 180 ILHHTSECTQ MDHLGCLHYT VRAPVGIAAL ISPWNLPLYL LTWKIAPAIA AGNTVIAKPS 190 200 210 220 230 240 ELTSVTAWMM CRLLEKAGVP PGVVNIVFGT GPRVGEALVS HPEVPLISFT GSQPTAERIM 250 260 270 280 290 300 QLSAPHCKKL SLELGGKNPA VIFEDANLAE CIPTTVRSSF ANQGEICLCT SRIFVQRSIY 310 320 330 340 350 360 SEFLKRFVEA ARMWKVGIPS DPSADMGALI SKAHLEKVRS YIKKARMEGA QILCGEGVDK 370 380 390 400 410 420 LNLPPRNQAG YFMLPTVITD VKDESCCMKE EIFGPVTCVV PFDSEEEVIQ RANNVKYGLA 430 440 450 460 470 480 ATVWSGNVGR VHRVAKKLQS GLVWTNCWLI RELNLPFGGM KSSGVGREGA KDSYEFFTEV KTITVKH

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BT029881 mRNA. Translation: ABM06132.1. BC120092 mRNA. Translation: AAI20093.1.
IPI	IPI00686961.
RefSeq	NP_001069094.1.
UniGene	Bt.43302
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000007975. Bos taurus. [Contig view]
GeneID	513537.
KEGG	bta:513537.
Phylogenomic databases
HOVERGEN	Q0P5F9.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL8A1_BOVIN

Accession

Primary (citable) accession number: Q0P5F9
Secondary accession number(s): A1L594

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 19, 2006
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)