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Q0P5F0 (PPAL_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosomal acid phosphatase

Short name=LAP
EC=3.1.3.2
Gene names
Name:ACP2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Subcellular location

Lysosome membrane; Single-pass membrane protein; Lumenal side By similarity. Lysosome lumen By similarity. Note: The soluble form arises by proteolytic processing of the membrane-bound form By similarity.

Post-translational modification

The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen By similarity.

Sequence similarities

Belongs to the histidine acid phosphatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 By similarity
Chain31 – 423393Lysosomal acid phosphatase
PRO_0000352520

Regions

Topological domain31 – 380350Lumenal Potential
Transmembrane381 – 40121Helical; Potential
Topological domain402 – 42322Cytoplasmic Potential

Sites

Active site421Nucleophile By similarity
Active site2871Proton donor By similarity

Amino acid modifications

Glycosylation921N-linked (GlcNAc...) Potential
Glycosylation1331N-linked (GlcNAc...) Potential
Glycosylation1671N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation1911N-linked (GlcNAc...) Potential
Glycosylation2671N-linked (GlcNAc...) Potential
Glycosylation3221N-linked (GlcNAc...) Potential
Glycosylation3311N-linked (GlcNAc...) Potential
Disulfide bond159 ↔ 370 By similarity
Disulfide bond212 ↔ 310 By similarity
Disulfide bond345 ↔ 349 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0P5F0 [UniParc].

Last modified September 19, 2006. Version 1.
Checksum: A22B7E4B74CA57F6

FASTA42348,302
        10         20         30         40         50         60 
MAGRRFGWSR AALLQLILGV NLMVMPRTQA RTLRFVTLLY RHGDRSPVKA YPKDPHQEDK 

        70         80         90        100        110        120 
WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV YVRSTDFDRT LMSAEANLAG 

       130        140        150        160        170        180 
LFPPDGIQRF NPNISWQPIP VHTVPVAEDR LLKFPLGPCP RFEQLQNETR RMPEYQNESV 

       190        200        210        220        230        240 
QNAQFLDMVA NETGLTDLSL ETVWNVYDTL FCEQTHGLPL PPWASPQTMQ RLSRLKDFSF 

       250        260        270        280        290        300 
RFLFGIYKQA EKARLQGGVL LAQIRKNLTL MATTSQLPKL LVYSAHDTTL VALHMALGVY 

       310        320        330        340        350        360 
NGEQAPYASC HMFELYQEDS GNFSVEMYFR NESHRAPWPL TLPGCSHRCP LQDFLRLTEP 

       370        380        390        400        410        420 
VVPKDWLQEC QLAGGPADTE VIVALAVCGS ILFLLIVLLL TVLFRVQAQP PGYRHVPDGE 


DHA 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal pons.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC120138 mRNA. Translation: AAI20139.1.
RefSeqNP_001069526.1. NM_001076058.2.
UniGeneBt.43294.

3D structure databases

ProteinModelPortalQ0P5F0.
SMRQ0P5F0. Positions 31-371.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000027968.

Proteomic databases

PRIDEQ0P5F0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000027968; ENSBTAP00000027968; ENSBTAG00000021002.
GeneID535407.
KEGGbta:535407.

Organism-specific databases

CTD53.

Phylogenomic databases

eggNOGNOG85977.
GeneTreeENSGT00530000062956.
HOGENOMHOG000231439.
HOVERGENHBG002203.
InParanoidQ0P5F0.
KOK14410.
OMAQDFLHLT.
OrthoDBEOG7GXPBJ.
TreeFamTF312893.

Family and domain databases

Gene3D3.40.50.1240. 1 hit.
InterProIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMSSF53254. SSF53254. 1 hit.
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20876735.

Entry information

Entry namePPAL_BOVIN
AccessionPrimary (citable) accession number: Q0P5F0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: September 19, 2006
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families