Reviewed,
UniProtKB/Swiss-Prot Q0P5F0 (PPAL_BOVIN)
Last modified
November 3, 2009.
Version 26.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Lysosomal acid phosphatase Short name=LAP EC=3.1.3.2 | ||
| Gene names |
| ||
| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 423 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | A phosphate monoester + H2O = an alcohol + phosphate. |
| Subcellular location | Lysosome membrane; Single-pass membrane protein; Lumenal side By similarity. Lysosome lumen By similarity. Note: The soluble form arises by proteolytic processing of the membrane-bound form By similarity. |
| Post-translational modification | The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen By similarity. |
| Sequence similarities | Belongs to the histidine acid phosphatase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Lysosome Membrane |
| Domain | Signal Transmembrane |
| Molecular function | Hydrolase |
| PTM | Disulfide bond Glycoprotein |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW lysosomal lumenInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | acid phosphatase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 30 | 30 | By similarity | ||||||||
| Chain | 31 – 423 | 393 | Lysosomal acid phosphatase | PRO_0000352520 | |||||||
Regions | |||||||||||
| Topological domain | 31 – 380 | 350 | Lumenal Potential | ||||||||
| Transmembrane | 381 – 401 | 21 | Potential | ||||||||
| Topological domain | 402 – 423 | 22 | Cytoplasmic Potential | ||||||||
Sites | |||||||||||
| Active site | 42 | 1 | Nucleophile By similarity | ||||||||
| Active site | 287 | 1 | Proton donor By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 92 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 133 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 167 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 177 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 191 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 267 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 322 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 331 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 159 ↔ 370 | By similarity | |||||||||
| Disulfide bond | 212 ↔ 310 | By similarity | |||||||||
| Disulfide bond | 345 ↔ 349 | By similarity | |||||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal pons. |
Cross-references
Sequence databases | |
|---|---|
| BC120138 mRNA. Translation: AAI20139.1. | |
| IPI | IPI00717351. |
| RefSeq | NP_001069526.1. |
| UniGene | Bt.43294 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAT00000027968; ENSBTAP00000027968; ENSBTAG00000021002; Bos taurus. [Genome view] |
| GeneID | 535407. |
| KEGG | bta:535407. |
Organism-specific databases | |
| CTD | 535407. |
Phylogenomic databases | |
| HOVERGEN | Q0P5F0. |
| OMA | ELYQEDS. |
Family and domain databases | |
| InterPro | IPR000560. Histidine_acid_Pase. [Graphical view] |
| Pfam | PF00328. Acid_phosphat_A. 1 hit. [Graphical view] |
| PROSITE | PS00616. HIS_ACID_PHOSPHAT_1. 1 hit. PS00778. HIS_ACID_PHOSPHAT_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PPAL_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q0P5F0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


