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Protein

Alpha-1-syntrophin

Gene

SNTA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-syntrophin
Gene namesi
Name:SNTA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002956621 – 505Alpha-1-syntrophinAdd BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei101PhosphoserineBy similarity1
Modified residuei184PhosphoserineBy similarity1
Modified residuei189PhosphoserineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei200PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0P5E6.
PRIDEiQ0P5E6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000000512.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with the dystrophin related protein DTNA; SGCG of the dystrophin glycoprotein complex; NOS1; GRB2; GA; TGFA; MAPK12 and the sodium channel proteins SCN4A and SCN5A. Interacts with the dystrophin protein DMD in a calmodulin dependent manner and with related protein UTRN; SGCA of the dystrophin glycoprotein complex; F-actin; calmodulin and with the other members of the syntrophin family SNTB1 and SNTB2. Interacts with MYOC; regulates muscle hypertrophy (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000662.

Structurei

3D structure databases

ProteinModelPortaliQ0P5E6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 269PH 1PROSITE-ProRule annotationAdd BLAST264
Domaini87 – 170PDZPROSITE-ProRule annotationAdd BLAST84
Domaini293 – 401PH 2PROSITE-ProRule annotationAdd BLAST109
Domaini449 – 505SUAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni483 – 505Calmodulin-bindingBy similarityAdd BLAST23

Domaini

The PH 1 domain mediates the oligomerization in a calcium dependent manner, and the association with the phosphatidylinositol 4,5-bisphosphate.By similarity
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).By similarity
The SU domain binds calmodulin in a calcium-dependent manner (By similarity). It contains actin-binding sites.By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IMRM. Eukaryota.
ENOG410XS4Y. LUCA.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000231596.
HOVERGENiHBG054204.
InParanoidiQ0P5E6.
OMAiKEMSAFF.
OrthoDBiEOG091G0O31.
TreeFamiTF317932.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR028552. SNTA1.
IPR015482. Syntrophin.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 1 hit.
PTHR10554:SF6. PTHR10554:SF6. 1 hit.
PfamiPF00595. PDZ. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0P5E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGRRAPRT GLLELRAGAG SGAGGERWQR AVLSLEEDAL TVSPADGEPG
60 70 80 90 100
PEPGAQREPE PAQLNGAAEP GAASPPLPEA LLLQPRRVTV RKADAGGLGI
110 120 130 140 150
SIKGGRENKM PILISKIFKG LAADQTEALF VGDAILSVNG EDLSSATHDE
160 170 180 190 200
AVQVLKKTGK EVVLEVKYMK EVSPYFKNSA SGTSVGWDSP PASPLQRQPS
210 220 230 240 250
SPGPPPRDLR DAKHMSLKMA YVSRRCTPTD PETRYLEICS ADGRDTLFLR
260 270 280 290 300
AKDEASAKSW AAAIQAQVNT LTPRVKDELQ ALLSATSTAG SQDIKRIGWL
310 320 330 340 350
TEQLPSGGTA PTLALLTEKE LLLYSCLPQT REALSRPART APLITTRLVH
360 370 380 390 400
SGPSKGSVPY DAELSFALRT GTRHGVDTHL FSVESPQELA AWTRQLVDGC
410 420 430 440 450
HRAAEGVQEV STACTWNGRA CSLSVHIDNG FTLWAAEPGA ARAVLLRQPF
460 470 480 490 500
EKLQMSSDDG ASLLFLDFGG AEGEIQLDLH SCPKTMVFII HSFLSAKVTR

LGLLA
Length:505
Mass (Da):53,873
Last modified:September 19, 2006 - v1
Checksum:i32262C6284D5D7A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120146 mRNA. Translation: AAI20147.1.
RefSeqiNP_001069366.1. NM_001075898.2.
UniGeneiBt.27627.

Genome annotation databases

EnsembliENSBTAT00000000662; ENSBTAP00000000662; ENSBTAG00000000512.
GeneIDi527488.
KEGGibta:527488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120146 mRNA. Translation: AAI20147.1.
RefSeqiNP_001069366.1. NM_001075898.2.
UniGeneiBt.27627.

3D structure databases

ProteinModelPortaliQ0P5E6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000662.

Proteomic databases

PaxDbiQ0P5E6.
PRIDEiQ0P5E6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000000662; ENSBTAP00000000662; ENSBTAG00000000512.
GeneIDi527488.
KEGGibta:527488.

Organism-specific databases

CTDi6640.

Phylogenomic databases

eggNOGiENOG410IMRM. Eukaryota.
ENOG410XS4Y. LUCA.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000231596.
HOVERGENiHBG054204.
InParanoidiQ0P5E6.
OMAiKEMSAFF.
OrthoDBiEOG091G0O31.
TreeFamiTF317932.

Gene expression databases

BgeeiENSBTAG00000000512.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR028552. SNTA1.
IPR015482. Syntrophin.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 1 hit.
PTHR10554:SF6. PTHR10554:SF6. 1 hit.
PfamiPF00595. PDZ. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNTA1_BOVIN
AccessioniPrimary (citable) accession number: Q0P5E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: September 19, 2006
Last modified: October 5, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.