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Protein

Derlin-3

Gene

DERL3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins. May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Derlin-3Curated
Alternative name(s):
Der1-like protein 3By similarity
Gene namesi
Name:DERL3By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini44 – 58LumenalSequence analysisAdd BLAST15
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 98CytoplasmicSequence analysisAdd BLAST19
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 157LumenalSequence analysisAdd BLAST38
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 231CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002840771 – 231Derlin-3Add BLAST231

Proteomic databases

PaxDbiQ0P5E4.

Interactioni

Subunit structurei

Forms homo- and heterooligomers with DERL2 and, to a lesser extent, with DERL1. Interacts with VCP and EDEM1. Interacts with SELENOK and SELENOS. Interact with the signal recognition particle/SRP and the SRP receptor; in the process of endoplasmic reticulum stress-induced pre-emptive quality control.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029459.

Structurei

3D structure databases

ProteinModelPortaliQ0P5E4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the derlin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0858. Eukaryota.
COG5291. LUCA.
HOGENOMiHOG000200948.
HOVERGENiHBG051338.
InParanoidiQ0P5E4.
KOiK13989.

Family and domain databases

Gene3Di1.20.1540.10. 1 hit.
InterProiView protein in InterPro
IPR007599. DER1.
IPR022764. Peptidase_S54_rhomboid_dom.
PANTHERiPTHR11009. PTHR11009. 1 hit.
SUPFAMiSSF144091. SSF144091. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0P5E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWQGLATEF LQVPAVTRTY TAACVLTTAA VQLELLSPFQ LYFNPHLVFR
60 70 80 90 100
KFQVWRLITN FLFFGPLGFS FFFNMLFVFR YCRMLEEGSF RGRTADFVFM
110 120 130 140 150
FLFGGVLMTL LGLLGSLFFL GQALTAMLVY VWSRRSPGVR VNFFGLLTFQ
160 170 180 190 200
APFLPWALMG LPMLLGNSIL VDLLGIAVGH VYYFLEDVFP NQPGGKRLLL
210 220 230
TPSFLKLLLD APEEDPNYLP LPEEQPGPLQ Q
Length:231
Mass (Da):26,248
Last modified:September 19, 2006 - v1
Checksum:iBA834B1BC45C3B04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120164 mRNA. Translation: AAI20165.1.
RefSeqiNP_001069791.1. NM_001076323.2.
UniGeneiBt.21056.

Genome annotation databases

GeneIDi614334.
KEGGibta:614334.

Similar proteinsi

Entry informationi

Entry nameiDERL3_BOVIN
AccessioniPrimary (citable) accession number: Q0P5E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: September 19, 2006
Last modified: May 10, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families