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Protein

Rho guanine nucleotide exchange factor 39

Gene

ARHGEF39

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes cell proliferation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 39
Gene namesi
Name:ARHGEF39
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Rho guanine nucleotide exchange factor 39PRO_0000291863Add
BLAST

Proteomic databases

PaxDbiQ0P5E3.
PRIDEiQ0P5E3.

Structurei

3D structure databases

ProteinModelPortaliQ0P5E3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 197176DHPROSITE-ProRule annotationAdd
BLAST
Domaini227 – 331105PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IE9S. Eukaryota.
ENOG4110AJV. LUCA.
GeneTreeiENSGT00440000033863.
HOGENOMiHOG000035112.
HOVERGENiHBG058322.
InParanoidiQ0P5E3.
OMAiCPHLELY.
OrthoDBiEOG73NG3M.
TreeFamiTF350447.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0P5E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESPAPGARC PVQEQRARWE RKRACTAREL LETERRYQEQ LGLVATYFVA
60 70 80 90 100
ILRAKGTLRP PERQALFGPW ELIYGASQEL LPYLEGGRWG QGLEGFCNHL
110 120 130 140 150
ELYTQFAANV ERSRTILQEQ LKKNKHFRRF VRLQEGRPEF GGLQLQDLLP
160 170 180 190 200
LPLQRLQQYE NLAVALAENT GPNSPEHKQL TRAAQLISET AQRVHTIGQK
210 220 230 240 250
QKNEQHLQRI QALLSGRQAK GLISGRWFLR QGWLLVVPPR GEPRPRMFFL
260 270 280 290 300
FSDALLMAKP RPPLHLLQSG TFACRALYPM GECQLHRVFG HSGGPCGGLL
310 320 330
SLSFPHEKLL LMSTDQEELS HWYHSLTLAI SSQKN
Length:335
Mass (Da):38,282
Last modified:September 19, 2006 - v1
Checksum:i98FA8950C4F81C61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120169 mRNA. Translation: AAI20170.1.
BT026317 mRNA. Translation: ABG81473.1.
RefSeqiNP_001073268.1. NM_001079800.1.
UniGeneiBt.91078.

Genome annotation databases

EnsembliENSBTAT00000015167; ENSBTAP00000015167; ENSBTAG00000011416.
GeneIDi780881.
KEGGibta:780881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120169 mRNA. Translation: AAI20170.1.
BT026317 mRNA. Translation: ABG81473.1.
RefSeqiNP_001073268.1. NM_001079800.1.
UniGeneiBt.91078.

3D structure databases

ProteinModelPortaliQ0P5E3.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ0P5E3.
PRIDEiQ0P5E3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000015167; ENSBTAP00000015167; ENSBTAG00000011416.
GeneIDi780881.
KEGGibta:780881.

Organism-specific databases

CTDi84904.

Phylogenomic databases

eggNOGiENOG410IE9S. Eukaryota.
ENOG4110AJV. LUCA.
GeneTreeiENSGT00440000033863.
HOGENOMiHOG000035112.
HOVERGENiHBG058322.
InParanoidiQ0P5E3.
OMAiCPHLELY.
OrthoDBiEOG73NG3M.
TreeFamiTF350447.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-335.

Entry informationi

Entry nameiARG39_BOVIN
AccessioniPrimary (citable) accession number: Q0P5E3
Secondary accession number(s): Q0V8A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: September 19, 2006
Last modified: June 8, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.