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Protein

Rho guanine nucleotide exchange factor 39

Gene

ARHGEF39

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes cell proliferation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-BTA-193648 NRAGE signals death through JNK
R-BTA-194840 Rho GTPase cycle
R-BTA-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 39
Gene namesi
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 8

Organism-specific databases

VGNCiVGNC:26117 ARHGEF39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918631 – 335Rho guanine nucleotide exchange factor 39Add BLAST335

Proteomic databases

PaxDbiQ0P5E3
PRIDEiQ0P5E3

Expressioni

Gene expression databases

BgeeiENSBTAG00000011416

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015167

Structurei

3D structure databases

ProteinModelPortaliQ0P5E3
SMRiQ0P5E3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 197DHPROSITE-ProRule annotationAdd BLAST176
Domaini227 – 331PHPROSITE-ProRule annotationAdd BLAST105

Phylogenomic databases

eggNOGiENOG410IE9S Eukaryota
ENOG4110AJV LUCA
GeneTreeiENSGT00440000033863
HOGENOMiHOG000035112
HOVERGENiHBG058322
InParanoidiQ0P5E3
OMAiCPHLELY
OrthoDBiEOG091G0DTO
TreeFamiTF350447

Family and domain databases

Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q0P5E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESPAPGARC PVQEQRARWE RKRACTAREL LETERRYQEQ LGLVATYFVA
60 70 80 90 100
ILRAKGTLRP PERQALFGPW ELIYGASQEL LPYLEGGRWG QGLEGFCNHL
110 120 130 140 150
ELYTQFAANV ERSRTILQEQ LKKNKHFRRF VRLQEGRPEF GGLQLQDLLP
160 170 180 190 200
LPLQRLQQYE NLAVALAENT GPNSPEHKQL TRAAQLISET AQRVHTIGQK
210 220 230 240 250
QKNEQHLQRI QALLSGRQAK GLISGRWFLR QGWLLVVPPR GEPRPRMFFL
260 270 280 290 300
FSDALLMAKP RPPLHLLQSG TFACRALYPM GECQLHRVFG HSGGPCGGLL
310 320 330
SLSFPHEKLL LMSTDQEELS HWYHSLTLAI SSQKN
Length:335
Mass (Da):38,282
Last modified:September 19, 2006 - v1
Checksum:i98FA8950C4F81C61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120169 mRNA Translation: AAI20170.1
BT026317 mRNA Translation: ABG81473.1
RefSeqiNP_001073268.1, NM_001079800.1
UniGeneiBt.91078

Genome annotation databases

EnsembliENSBTAT00000015167; ENSBTAP00000015167; ENSBTAG00000011416
GeneIDi780881
KEGGibta:780881

Similar proteinsi

Entry informationi

Entry nameiARG39_BOVIN
AccessioniPrimary (citable) accession number: Q0P5E3
Secondary accession number(s): Q0V8A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: September 19, 2006
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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