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Protein

Arylacetamide deacetylase

Gene

AADAC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity (By similarity).By similarity

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei189 – 1891PROSITE-ProRule annotation
Active sitei343 – 3431By similarity
Active sitei373 – 3731By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERibovin-aaad. Hormone-sensitive_lipase_like_1.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylacetamide deacetylase (EC:3.1.1.3)
Gene namesi
Name:AADAC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44CytoplasmicSequence analysis
Transmembranei5 – 2521Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini26 – 399374LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Arylacetamide deacetylasePRO_0000269569Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi116 ↔ 340By similarity
Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ0P5B7.
PeptideAtlasiQ0P5B7.
PRIDEiQ0P5B7.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015373.

Structurei

3D structure databases

ProteinModelPortaliQ0P5B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi111 – 1133Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000033738.
HOVERGENiHBG058974.
InParanoidiQ0P5B7.
KOiK13616.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR017157. Arylacetamide_deacetylase.
IPR033140. Lipase_GDXG_put_SER_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 2 hits.
[Graphical view]
PIRSFiPIRSF037251. Arylacetamide_deacetylase. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0P5B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKKYFGFLI LGVLLAGYIY VPLPDNVEEP WKIMLLNTFL KTSSYLALFG
60 70 80 90 100
EILGLNHFMK SMALFSRIQG FPPTSDENII VKDTTFNDIP VRIYVPQQKT
110 120 130 140 150
KSLRRGLFYI HGGGWCFGSN DYYSYDLLSR WTAERLDAVV ISTNYRLAPK
160 170 180 190 200
YHFPVQFEDV YTALKWFLDP QNLESYGVDP GRIGISGDSA GGNLAAAVAQ
210 220 230 240 250
QLLEDPDVKI KLKVQTLIYP ALQNFDFDLP SYRENAHYPV LSKSLMVRFW
260 270 280 290 300
SEYFTTDRSL KKAMLSNQHI PLESSNLFKF VNWSSLLPEK FKKGHIYKTP
310 320 330 340 350
THGSSELAKK YPGILDVKAS PLLADDSKLR GLPLTYVITC QYDVLRDDGL
360 370 380 390
MYVTRLQKSG VQVIHNHVEG AFHGTLAFLF TKVGYRAANQ YINWLHENL
Length:399
Mass (Da):45,604
Last modified:September 19, 2006 - v1
Checksum:iB18B0BB5BFC0126C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120261 mRNA. Translation: AAI20262.1.
RefSeqiNP_001069259.1. NM_001075791.2.
UniGeneiBt.58935.

Genome annotation databases

GeneIDi519557.
KEGGibta:519557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120261 mRNA. Translation: AAI20262.1.
RefSeqiNP_001069259.1. NM_001075791.2.
UniGeneiBt.58935.

3D structure databases

ProteinModelPortaliQ0P5B7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015373.

Protein family/group databases

ESTHERibovin-aaad. Hormone-sensitive_lipase_like_1.

Proteomic databases

PaxDbiQ0P5B7.
PeptideAtlasiQ0P5B7.
PRIDEiQ0P5B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi519557.
KEGGibta:519557.

Organism-specific databases

CTDi13.

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000033738.
HOVERGENiHBG058974.
InParanoidiQ0P5B7.
KOiK13616.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR017157. Arylacetamide_deacetylase.
IPR033140. Lipase_GDXG_put_SER_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 2 hits.
[Graphical view]
PIRSFiPIRSF037251. Arylacetamide_deacetylase. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAAAD_BOVIN
AccessioniPrimary (citable) accession number: Q0P5B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 19, 2006
Last modified: July 6, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.