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Protein

Methyltransferase-like protein 2

Gene

METTL2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 2 (EC:2.1.1.-)
Gene namesi
Name:METTL2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Methyltransferase-like protein 2PRO_0000328846Add
BLAST

Proteomic databases

PaxDbiQ0P5B2.
PRIDEiQ0P5B2.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012443.

Structurei

3D structure databases

ProteinModelPortaliQ0P5B2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2361. Eukaryota.
ENOG410YAN4. LUCA.
GeneTreeiENSGT00520000055554.
HOGENOMiHOG000182278.
HOVERGENiHBG075344.
InParanoidiQ0P5B2.
OMAiDIIVMIF.
OrthoDBiEOG7VX8ZJ.
TreeFamiTF323232.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR026113. MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR22809. PTHR22809. 2 hits.
SUPFAMiSSF53335. SSF53335. 2 hits.

Sequencei

Sequence statusi: Complete.

Q0P5B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCSFPEGDP AAVCGKRQQF GSRFLSDPAR VFHHNAWDNV EWSEEQAAEA
60 70 80 90 100
ERKVQENSTQ RVCQEKQADY EINANKYWNN FYKIHENGFF KDRHWLFTEF
110 120 130 140 150
PELAPSQNHL KNLLSENKRS EVYEYYRSGE DGPDLTIEEQ HRCSSVSLGD
160 170 180 190 200
KTQPPLTEES VTQKLHHLEI CANEFPGSSA TYRILEVGCG VGNTVFPILQ
210 220 230 240 250
TNNDPSLFVY CCDFSSTAVE LVQTNSAYDP SRCFAFVHDL CDEDKSYPMP
260 270 280 290 300
ENSLDVIILI FVLSAIVPDK MQNAINRLSR LLKPGGIMLL RDYGRYDMAQ
310 320 330 340 350
LRFKKGQCLS ENFYVRGDGT RVYFFTQDEL DTLFTTAGLE KVQNLVDRRL
360 370
QVNRGKQLTM YRVWIQCKYR KPLGSSTG
Length:378
Mass (Da):43,485
Last modified:September 19, 2006 - v1
Checksum:iDB258FAF0FEEAE33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120275 mRNA. Translation: AAI20276.1.
RefSeqiNP_001068714.1. NM_001075246.2.
UniGeneiBt.37800.

Genome annotation databases

EnsembliENSBTAT00000012443; ENSBTAP00000012443; ENSBTAG00000009458.
GeneIDi506221.
KEGGibta:506221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120275 mRNA. Translation: AAI20276.1.
RefSeqiNP_001068714.1. NM_001075246.2.
UniGeneiBt.37800.

3D structure databases

ProteinModelPortaliQ0P5B2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012443.

Proteomic databases

PaxDbiQ0P5B2.
PRIDEiQ0P5B2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012443; ENSBTAP00000012443; ENSBTAG00000009458.
GeneIDi506221.
KEGGibta:506221.

Organism-specific databases

CTDi339175.

Phylogenomic databases

eggNOGiKOG2361. Eukaryota.
ENOG410YAN4. LUCA.
GeneTreeiENSGT00520000055554.
HOGENOMiHOG000182278.
HOVERGENiHBG075344.
InParanoidiQ0P5B2.
OMAiDIIVMIF.
OrthoDBiEOG7VX8ZJ.
TreeFamiTF323232.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR026113. MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR22809. PTHR22809. 2 hits.
SUPFAMiSSF53335. SSF53335. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal cerebellum.

Entry informationi

Entry nameiMETL2_BOVIN
AccessioniPrimary (citable) accession number: Q0P5B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: September 19, 2006
Last modified: June 8, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.