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Protein

Methyltransferase-like protein 2

Gene

METTL2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 2 (EC:2.1.1.-)
Gene namesi
Name:METTL2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003288461 – 378Methyltransferase-like protein 2Add BLAST378

Proteomic databases

PaxDbiQ0P5B2.
PRIDEiQ0P5B2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000009458.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012443.

Structurei

3D structure databases

ProteinModelPortaliQ0P5B2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2361. Eukaryota.
ENOG410YAN4. LUCA.
GeneTreeiENSGT00520000055554.
HOGENOMiHOG000182278.
HOVERGENiHBG075344.
InParanoidiQ0P5B2.
OMAiVFEFNAW.
OrthoDBiEOG091G1235.
TreeFamiTF323232.

Family and domain databases

InterProiView protein in InterPro
IPR026113. MeTrfase.
IPR029063. SAM-dependent_MTases.
PANTHERiPTHR22809. PTHR22809. 1 hit.
PIRSFiPIRSF037755. Mettl2_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.

Sequencei

Sequence statusi: Complete.

Q0P5B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCSFPEGDP AAVCGKRQQF GSRFLSDPAR VFHHNAWDNV EWSEEQAAEA
60 70 80 90 100
ERKVQENSTQ RVCQEKQADY EINANKYWNN FYKIHENGFF KDRHWLFTEF
110 120 130 140 150
PELAPSQNHL KNLLSENKRS EVYEYYRSGE DGPDLTIEEQ HRCSSVSLGD
160 170 180 190 200
KTQPPLTEES VTQKLHHLEI CANEFPGSSA TYRILEVGCG VGNTVFPILQ
210 220 230 240 250
TNNDPSLFVY CCDFSSTAVE LVQTNSAYDP SRCFAFVHDL CDEDKSYPMP
260 270 280 290 300
ENSLDVIILI FVLSAIVPDK MQNAINRLSR LLKPGGIMLL RDYGRYDMAQ
310 320 330 340 350
LRFKKGQCLS ENFYVRGDGT RVYFFTQDEL DTLFTTAGLE KVQNLVDRRL
360 370
QVNRGKQLTM YRVWIQCKYR KPLGSSTG
Length:378
Mass (Da):43,485
Last modified:September 19, 2006 - v1
Checksum:iDB258FAF0FEEAE33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120275 mRNA. Translation: AAI20276.1.
RefSeqiNP_001068714.1. NM_001075246.2.
UniGeneiBt.37800.

Genome annotation databases

EnsembliENSBTAT00000012443; ENSBTAP00000012443; ENSBTAG00000009458.
GeneIDi506221.
KEGGibta:506221.

Similar proteinsi

Entry informationi

Entry nameiMETL2_BOVIN
AccessioniPrimary (citable) accession number: Q0P5B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: September 19, 2006
Last modified: August 30, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families