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Q0P5A5

- CKS1_BOVIN

UniProt

Q0P5A5 - CKS1_BOVIN

Protein

Cyclin-dependent kinases regulatory subunit 1

Gene

CKS1B

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.By similarity

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    ReactomeiREACT_218138. Cyclin D associated events in G1.
    REACT_223494. SCF(Skp2)-mediated degradation of p27/p21.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinases regulatory subunit 1
    Short name:
    CKS-1
    Gene namesi
    Name:CKS1B
    Synonyms:CKS1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 3

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 7978Cyclin-dependent kinases regulatory subunit 1PRO_0000260446Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ0P5A5.

    Interactioni

    Subunit structurei

    Forms a homohexamer that can probably bind six kinase subunits.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000033878.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0P5A5.
    SMRiQ0P5A5. Positions 5-74.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CKS family.Curated

    Phylogenomic databases

    eggNOGiNOG272189.
    GeneTreeiENSGT00390000011006.
    HOVERGENiHBG003626.
    InParanoidiQ0P5A5.
    KOiK02219.
    OMAiRGWIHYM.
    OrthoDBiEOG735413.
    TreeFamiTF101142.

    Family and domain databases

    Gene3Di3.30.170.10. 1 hit.
    InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
    [Graphical view]
    PfamiPF01111. CKS. 1 hit.
    [Graphical view]
    PRINTSiPR00296. CYCLINKINASE.
    SMARTiSM01084. CKS. 1 hit.
    [Graphical view]
    SUPFAMiSSF55637. SSF55637. 1 hit.
    PROSITEiPS00944. CKS_1. 1 hit.
    PS00945. CKS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0P5A5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ   50
    SQGWVHYMIH EPEPHILLFR RPLPKKPKK 79
    Length:79
    Mass (Da):9,660
    Last modified:September 19, 2006 - v1
    Checksum:iE64207B140FA38D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC120301 mRNA. Translation: AAI20302.1.
    RefSeqiNP_001106782.1. NM_001113311.1.
    UniGeneiBt.20570.

    Genome annotation databases

    EnsembliENSBTAT00000033975; ENSBTAP00000033878; ENSBTAG00000024476.
    GeneIDi615827.
    KEGGibta:615827.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC120301 mRNA. Translation: AAI20302.1 .
    RefSeqi NP_001106782.1. NM_001113311.1.
    UniGenei Bt.20570.

    3D structure databases

    ProteinModelPortali Q0P5A5.
    SMRi Q0P5A5. Positions 5-74.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000033878.

    Proteomic databases

    PRIDEi Q0P5A5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000033975 ; ENSBTAP00000033878 ; ENSBTAG00000024476 .
    GeneIDi 615827.
    KEGGi bta:615827.

    Organism-specific databases

    CTDi 1163.

    Phylogenomic databases

    eggNOGi NOG272189.
    GeneTreei ENSGT00390000011006.
    HOVERGENi HBG003626.
    InParanoidi Q0P5A5.
    KOi K02219.
    OMAi RGWIHYM.
    OrthoDBi EOG735413.
    TreeFami TF101142.

    Enzyme and pathway databases

    Reactomei REACT_218138. Cyclin D associated events in G1.
    REACT_223494. SCF(Skp2)-mediated degradation of p27/p21.

    Miscellaneous databases

    NextBioi 20899807.

    Family and domain databases

    Gene3Di 3.30.170.10. 1 hit.
    InterProi IPR000789. Cyclin-dep_kinase_reg-sub.
    [Graphical view ]
    Pfami PF01111. CKS. 1 hit.
    [Graphical view ]
    PRINTSi PR00296. CYCLINKINASE.
    SMARTi SM01084. CKS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55637. SSF55637. 1 hit.
    PROSITEi PS00944. CKS_1. 1 hit.
    PS00945. CKS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Placenta.

    Entry informationi

    Entry nameiCKS1_BOVIN
    AccessioniPrimary (citable) accession number: Q0P5A5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: September 19, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3