ID   UCK1_BOVIN              Reviewed;         277 AA.
AC   Q0P5A4;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Uridine-cytidine kinase 1;
DE            Short=UCK 1;
DE            EC=2.7.1.48;
DE   AltName: Full=Uridine monophosphokinase 1;
DE   AltName: Full=Cytidine monophosphokinase 1;
GN   Name=UCK1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Phosphorylates uridine and cytidine to uridine
CC       monophosphate and cytidine monophosphate. Does not phosphorylate
CC       deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP
CC       as a phosphate donor (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + uridine = ADP + UMP.
CC   -!- CATALYTIC ACTIVITY: ATP + cytidine = ADP + CMP.
CC   -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage
CC       pathway; CTP from cytidine: step 1/3.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage
CC       pathway; UMP from uridine: step 1/1.
CC   -!- SIMILARITY: Belongs to the uridine kinase family.
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DR   EMBL; BC120304; AAI20305.1; -; mRNA.
DR   IPI; IPI00695829; -.
DR   RefSeq; NP_001069260.1; -.
DR   UniGene; Bt.42575; -.
DR   SMR; Q0P5A4; 22-235.
DR   Ensembl; ENSBTAG00000010810; Bos taurus.
DR   GeneID; 519697; -.
DR   KEGG; bta:519697; -.
DR   HOVERGEN; Q0P5A4; -.
DR   OMA; Q0P5A4; NQFIEPT.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group ...; IEA:InterPro.
DR   GO; GO:0004849; F:uridine kinase activity; IEA:EC.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR006083; PRK_URK.
DR   InterPro; IPR000764; Uridine_kinase.
DR   PANTHER; PTHR10285:SF6; Uridine_kin; 1.
DR   Pfam; PF00485; PRK; 1.
DR   PRINTS; PR00988; URIDINKINASE.
DR   TIGRFAMs; TIGR00235; udk; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Nucleotide-binding; Transferase.
FT   CHAIN         1    277       Uridine-cytidine kinase 1.
FT                                /FTId=PRO_0000346099.
FT   NP_BIND      30     38       ATP (By similarity).
FT   BINDING      87     87       Substrate (By similarity).
FT   BINDING     115    115       Substrate (By similarity).
FT   BINDING     120    120       Substrate (By similarity).
FT   BINDING     169    169       Substrate (By similarity).
FT   BINDING     178    178       Substrate (By similarity).
FT   BINDING     186    186       Substrate (By similarity).
FT   BINDING     215    215       ATP (By similarity).
SQ   SEQUENCE   277 AA;  31195 MW;  8D1284FE5D93A465 CRC64;
     MASAGGGDCE GAGPEADRPH QRPFLIGVSG GTASGKSTVC EKIMELLGQN EVDHRQRKLV
     ILSQDRFYKV LTAEQKAKAL KGQYNFDHPD AFDNDLMHRT LKNIVEGKTV EVPTYDFVTH
     SRLAETTVVY PADVVLFEGI LVFYSQEIRD MFHLRLFVDT DSDVRLSRRV LRDVQRGRDL
     EQILTQYTTF VKPAFEEFCL PTKKYADVII PRGVDNMVAI NLIVQHIQDI LNGDICKWHR
     AGANGRSHKR TFPEPGEHPA VLASGKRSHL ESSSRPH
//