Q0P5A4 (UCK1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uridine-cytidine kinase 1
Short name=UCK 1
EC=2.7.1.48

Alternative name(s):
Cytidine monophosphokinase 1
Uridine monophosphokinase 1

Gene names

Name:

UCK1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor By similarity.
Catalytic activity	ATP + uridine = ADP + UMP. ATP + cytidine = ADP + CMP.
Pathway	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.
Sequence similarities	Belongs to the uridine kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro uridine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Uridine-cytidine kinase 1		PRO_0000346099
Regions
	Nucleotide binding	30 – 38	9	ATP By similarity
Sites
	Binding site	87	1	Substrate By similarity
	Binding site	115	1	Substrate By similarity
	Binding site	120	1	Substrate By similarity
	Binding site	169	1	Substrate By similarity
	Binding site	178	1	Substrate By similarity
	Binding site	186	1	Substrate By similarity
	Binding site	215	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0P5A4 [UniParc]. Last modified September 19, 2006. Version 1. Checksum: 8D1284FE5D93A465	FASTA	277	31,195
	10 20 30 40 50 60 MASAGGGDCE GAGPEADRPH QRPFLIGVSG GTASGKSTVC EKIMELLGQN EVDHRQRKLV 70 80 90 100 110 120 ILSQDRFYKV LTAEQKAKAL KGQYNFDHPD AFDNDLMHRT LKNIVEGKTV EVPTYDFVTH 130 140 150 160 170 180 SRLAETTVVY PADVVLFEGI LVFYSQEIRD MFHLRLFVDT DSDVRLSRRV LRDVQRGRDL 190 200 210 220 230 240 EQILTQYTTF VKPAFEEFCL PTKKYADVII PRGVDNMVAI NLIVQHIQDI LNGDICKWHR 250 260 270 AGANGRSHKR TFPEPGEHPA VLASGKRSHL ESSSRPH

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Ascending colon.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC120304 mRNA. Translation: AAI20305.1.
IPI	IPI00695829.
RefSeq	NP_001069260.1. NM_001075792.1.
UniGene	Bt.42575.
3D structure databases
ProteinModelPortal	Q0P5A4.
SMR	Q0P5A4. Positions 22-235.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0P5A4.
Proteomic databases
PRIDE	Q0P5A4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000014316; ENSBTAP00000014316; ENSBTAG00000010810.
GeneID	519697.
KEGG	bta:519697.
Organism-specific databases
CTD	83549.
Phylogenomic databases
eggNOG	maNOG16810.
GeneTree	ENSGT00390000015696.
HOVERGEN	HBG023339.
InParanoid	Q0P5A4.
OMA	NQFVEPT.
OrthoDB	EOG4R7VBB.
PhylomeDB	Q0P5A4.
Family and domain databases
InterPro	IPR006083. PRK/URK. IPR000764. Uridine_kinase. [Graphical view]
KO	K00876.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00988. URIDINKINASE.
TIGRFAMs	TIGR00235. Udk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UCK1_BOVIN

Accession

Primary (citable) accession number: Q0P5A4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	September 19, 2006
Last modified:	November 16, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program