Q0P5A4 (UCK1_BOVIN) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 48.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Uridine-cytidine kinase 1 Short name=UCK 1 EC=2.7.1.48 Alternative name(s): Cytidine monophosphokinase 1 Uridine monophosphokinase 1 | ||
| Gene names |
| ||
| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 277 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor By similarity. |
| Catalytic activity | ATP + uridine = ADP + UMP. ATP + cytidine = ADP + CMP. |
| Pathway | Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. |
| Sequence similarities | Belongs to the uridine kinase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphotransferase activity, alcohol group as acceptorInferred from electronic annotation. Source: InterPro uridine kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 277 | 277 | Uridine-cytidine kinase 1 | PRO_0000346099 | |||||
Regions | |||||||||
| Nucleotide binding | 30 – 38 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Binding site | 87 | 1 | Substrate By similarity | ||||||
| Binding site | 115 | 1 | Substrate By similarity | ||||||
| Binding site | 120 | 1 | Substrate By similarity | ||||||
| Binding site | 169 | 1 | Substrate By similarity | ||||||
| Binding site | 178 | 1 | Substrate By similarity | ||||||
| Binding site | 186 | 1 | Substrate By similarity | ||||||
| Binding site | 215 | 1 | ATP By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Ascending colon. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC120304 mRNA. Translation: AAI20305.1. |
| IPI | IPI00695829. |
| RefSeq | NP_001069260.1. NM_001075792.1. |
| UniGene | Bt.42575. |
3D structure databases | |
| ProteinModelPortal | Q0P5A4. |
| SMR | Q0P5A4. Positions 22-235. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q0P5A4. |
Proteomic databases | |
| PRIDE | Q0P5A4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAT00000014316; ENSBTAP00000014316; ENSBTAG00000010810. |
| GeneID | 519697. |
| KEGG | bta:519697. |
Organism-specific databases | |
| CTD | 83549. |
Phylogenomic databases | |
| eggNOG | maNOG16810. |
| GeneTree | ENSGT00390000015696. |
| HOVERGEN | HBG023339. |
| InParanoid | Q0P5A4. |
| OMA | NQFVEPT. |
| OrthoDB | EOG4R7VBB. |
| PhylomeDB | Q0P5A4. |
Family and domain databases | |
| InterPro | IPR006083. PRK/URK. IPR000764. Uridine_kinase. [Graphical view] |
| KO | K00876. |
| Pfam | PF00485. PRK. 1 hit. [Graphical view] |
| PRINTS | PR00988. URIDINKINASE. |
| TIGRFAMs | TIGR00235. Udk. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | UCK1_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q0P5A4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with