Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q0P5A4 (UCK1_BOVIN)

Last modified June 16, 2009. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Uridine-cytidine kinase 1
      Short name=UCK 1
    EC=2.7.1.48
Alternative name(s):
    Uridine monophosphokinase 1
    Cytidine monophosphokinase 1
Gene names
Name: UCK1
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Hide | Top

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor By similarity.

Catalytic activity

ATP + uridine = ADP + UMP.

ATP + cytidine = ADP + CMP.

Pathway

Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.

Sequence similarities

Belongs to the uridine kinase family.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Uridine-cytidine kinase 1
PRO_0000346099

Regions

Nucleotide binding30 – 389ATP By similarity

Sites

Binding site871Substrate By similarity
Binding site1151Substrate By similarity
Binding site1201Substrate By similarity
Binding site1691Substrate By similarity
Binding site1781Substrate By similarity
Binding site1861Substrate By similarity
Binding site2151ATP By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q0P5A4-1 [UniParc].

Last modified September 19, 2006. Version 1.
Checksum: 8D1284FE5D93A465

FASTA27731,195
        10         20         30         40         50         60 
MASAGGGDCE GAGPEADRPH QRPFLIGVSG GTASGKSTVC EKIMELLGQN EVDHRQRKLV 

        70         80         90        100        110        120 
ILSQDRFYKV LTAEQKAKAL KGQYNFDHPD AFDNDLMHRT LKNIVEGKTV EVPTYDFVTH 

       130        140        150        160        170        180 
SRLAETTVVY PADVVLFEGI LVFYSQEIRD MFHLRLFVDT DSDVRLSRRV LRDVQRGRDL 

       190        200        210        220        230        240 
EQILTQYTTF VKPAFEEFCL PTKKYADVII PRGVDNMVAI NLIVQHIQDI LNGDICKWHR 

       250        260        270 
AGANGRSHKR TFPEPGEHPA VLASGKRSHL ESSSRPH

« Hide

Hide | Top

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Ascending colon.

Hide | Top

Cross-references

Sequence databases

BC120304 mRNA. Translation: AAI20305.1.
IPIIPI00695829.
RefSeqNP_001069260.1.
UniGeneBt.42575

3D structure databases

SMRQ0P5A4. Positions 22-235.
ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000010810. Bos taurus. [Contig view]
GeneID519697.
KEGGbta:519697.

Phylogenomic databases

HOVERGENQ0P5A4.
OMAQ0P5A4. NQFIEPT.

Family and domain databases

InterProIPR006083. PRK_URK.
IPR000764. Uridine_kinase.
[Graphical view]
PANTHERPTHR10285:SF6. Uridine_kin. 1 hit.
PfamPF00485. PRK. 1 hit.
[Graphical view]
PRINTSPR00988. URIDINKINASE.
TIGRFAMsTIGR00235. udk. 1 hit.
ProtoNetSearch...

Hide | Top

Entry information

Entry nameUCK1_BOVIN
AccessionPrimary (citable) accession number: Q0P5A4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 19, 2006
Last modified: June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents