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Protein

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Gene

COQ5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171S-adenosyl-L-methionineUniRule annotation
Binding sitei171 – 1711S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialUniRule annotation (EC:2.1.1.201UniRule annotation)
Alternative name(s):
Ubiquinone biosynthesis methyltransferase COQ5UniRule annotation
Gene namesi
Name:COQ5UniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4242MitochondrionSequence analysisAdd
BLAST
Chaini43 – 3302882-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialPRO_0000283067Add
BLAST

Proteomic databases

PaxDbiQ0P5A2.
PRIDEiQ0P5A2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015761.

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020929.

Structurei

3D structure databases

ProteinModelPortaliQ0P5A2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2002S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1540. Eukaryota.
COG2226. LUCA.
GeneTreeiENSGT00390000001654.
HOGENOMiHOG000249463.
HOVERGENiHBG081303.
InParanoidiQ0P5A2.
KOiK06127.
OMAiGGLHRAW.
OrthoDBiEOG091G0G2Z.
TreeFamiTF106217.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
HAMAPiMF_01813. MenG_UbiE_methyltr. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0P5A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPRSWALW SFCGCGWSRA VSGCRLPGLR SSSPRGPLGA RLLSQEKEAT
60 70 80 90 100
ETHFGFETVS EEEKGGKVYQ VFESVAKKYD VMNDMMSLGI HRVWKDLLLW
110 120 130 140 150
KMRPFPGTQL LDVAGGTGDI AFRFLNYVQA QHQRKQKRQL RAQQNLSWEE
160 170 180 190 200
IARKYQNEED SLGGSHVMVC DINKEMLKIG KQKARAQGYK AGLAWILGDA
210 220 230 240 250
EELPFDDNKF DVYTIAFGIR NVTHIDQALQ EAHRVLKPGG RFLCLEFSQV
260 270 280 290 300
NNPLLSRLYD VYSFQVIPVL GEVIAGDWKS YQYLVESIRQ FPSQEEFKEM
310 320 330
IEDAGFQKVT YENLTSGIVA IHSGFKLYLR
Length:330
Mass (Da):37,591
Last modified:September 19, 2006 - v1
Checksum:i0D2DCE9577ED942E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120308 mRNA. Translation: AAI20309.1.
RefSeqiXP_010812368.1. XM_010814066.2.
XP_010821736.1. XM_010823434.2.
UniGeneiBt.5676.

Genome annotation databases

EnsembliENSBTAT00000020929; ENSBTAP00000020929; ENSBTAG00000015761.
GeneIDi533208.
KEGGibta:533208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120308 mRNA. Translation: AAI20309.1.
RefSeqiXP_010812368.1. XM_010814066.2.
XP_010821736.1. XM_010823434.2.
UniGeneiBt.5676.

3D structure databases

ProteinModelPortaliQ0P5A2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020929.

Proteomic databases

PaxDbiQ0P5A2.
PRIDEiQ0P5A2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020929; ENSBTAP00000020929; ENSBTAG00000015761.
GeneIDi533208.
KEGGibta:533208.

Organism-specific databases

CTDi84274.

Phylogenomic databases

eggNOGiKOG1540. Eukaryota.
COG2226. LUCA.
GeneTreeiENSGT00390000001654.
HOGENOMiHOG000249463.
HOVERGENiHBG081303.
InParanoidiQ0P5A2.
KOiK06127.
OMAiGGLHRAW.
OrthoDBiEOG091G0G2Z.
TreeFamiTF106217.

Enzyme and pathway databases

UniPathwayiUPA00232.

Gene expression databases

BgeeiENSBTAG00000015761.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
HAMAPiMF_01813. MenG_UbiE_methyltr. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOQ5_BOVIN
AccessioniPrimary (citable) accession number: Q0P5A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 19, 2006
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.