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Protein

Succinate dehydrogenase assembly factor 3, mitochondrial

Gene

SDHAF3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.By similarity

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase assembly factor 3, mitochondrialBy similarity
Short name:
SDH assembly factor 3By similarity
Short name:
SDHAF3By similarity
Gene namesi
Name:SDHAF3By similarity
Synonyms:ACN9By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

  • Mitochondrion matrix By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionSequence analysisAdd
BLAST
Chaini31 – 12595Succinate dehydrogenase assembly factor 3, mitochondrialPRO_0000328458Add
BLAST

Proteomic databases

PaxDbiQ0P574.
PRIDEiQ0P574.

Interactioni

Subunit structurei

Interacts with SDHB within an SDHA-SDHB subcomplex.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021172.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family. SDHAF3 subfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4100. Eukaryota.
ENOG4111Y90. LUCA.
GeneTreeiENSGT00390000010029.
HOGENOMiHOG000039506.
HOVERGENiHBG080818.
InParanoidiQ0P574.
OMAiEFRRHKS.
OrthoDBiEOG72NRS8.
TreeFamiTF105635.

Family and domain databases

InterProiIPR008381. ACN9.
[Graphical view]
PANTHERiPTHR13137. PTHR13137. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0P574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALHVSRVR ALYRRILLLH RVLPPDLKDL GDRYVKDEFR RHKTAGSKEA
60 70 80 90 100
ERFLQEWEAY AAVLWQQANE SRQNSTEKAC FGISLPEEKL NDFRDEQIGQ
110 120
LQELMQEATK PNRQFNITES RKPKL
Length:125
Mass (Da):14,754
Last modified:September 19, 2006 - v1
Checksum:i6D346FE5DAA5EEB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120424 mRNA. Translation: AAI20425.1.
RefSeqiNP_001073821.1. NM_001080352.1.
UniGeneiBt.16149.

Genome annotation databases

EnsembliENSBTAT00000021172; ENSBTAP00000021172; ENSBTAG00000015925.
GeneIDi783805.
KEGGibta:783805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120424 mRNA. Translation: AAI20425.1.
RefSeqiNP_001073821.1. NM_001080352.1.
UniGeneiBt.16149.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021172.

Proteomic databases

PaxDbiQ0P574.
PRIDEiQ0P574.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021172; ENSBTAP00000021172; ENSBTAG00000015925.
GeneIDi783805.
KEGGibta:783805.

Organism-specific databases

CTDi57001.

Phylogenomic databases

eggNOGiKOG4100. Eukaryota.
ENOG4111Y90. LUCA.
GeneTreeiENSGT00390000010029.
HOGENOMiHOG000039506.
HOVERGENiHBG080818.
InParanoidiQ0P574.
OMAiEFRRHKS.
OrthoDBiEOG72NRS8.
TreeFamiTF105635.

Miscellaneous databases

NextBioi20926315.

Family and domain databases

InterProiIPR008381. ACN9.
[Graphical view]
PANTHERiPTHR13137. PTHR13137. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Basal ganglia.

Entry informationi

Entry nameiSDHF3_BOVIN
AccessioniPrimary (citable) accession number: Q0P574
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: September 19, 2006
Last modified: April 13, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.