ID   ERG19_BOVIN             Reviewed;         400 AA.
AC   Q0P570;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Diphosphomevalonate decarboxylase;
DE            EC=4.1.1.33;
DE   AltName: Full=Mevalonate pyrophosphate decarboxylase;
DE   AltName: Full=Mevalonate (diphospho)decarboxylase;
GN   Name=MVD;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Performs the first committed step in the biosynthesis of
CC       isoprenes (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + (R)-5-diphosphomevalonate = ADP +
CC       phosphate + isopentenyl diphosphate + CO(2).
CC   -!- PATHWAY: Steroid biosynthesis; cholesterol biosynthesis.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the diphosphomevalonate decarboxylase
CC       family.
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DR   EMBL; BC120432; AAI20433.1; -; mRNA.
DR   IPI; IPI00690789; -.
DR   RefSeq; NP_001068892.1; -.
DR   UniGene; Bt.3884; -.
DR   Ensembl; ENSBTAG00000012059; Bos taurus.
DR   GeneID; 509958; -.
DR   KEGG; bta:509958; -.
DR   HOVERGEN; Q0P570; -.
DR   BRENDA; 4.1.1.33; 251.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004163; F:diphosphomevalonate decarboxylase activity; IEA:EC.
DR   GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR   GO; GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:InterPro.
DR   InterPro; IPR006204; GHMP_kinase.
DR   InterPro; IPR013750; GHMP_kinase_C.
DR   InterPro; IPR005935; Mev_diP_decarb.
DR   PANTHER; PTHR10977; Mev_diP_decarb; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF015950; Mev_P_decrbx; 1.
DR   TIGRFAMs; TIGR01240; mevDPdecarb; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cholesterol biosynthesis; Lipid synthesis; Lyase;
KW   Nucleotide-binding; Steroid biosynthesis; Sterol biosynthesis.
FT   CHAIN         1    400       Diphosphomevalonate decarboxylase.
FT                                /FTId=PRO_0000310437.
SQ   SEQUENCE   400 AA;  43732 MW;  C659D6635C9EF49B CRC64;
     MASEKPIVVV TCTAPVNIAV VKYWGKRDEE LILPINSSLS VTLHQDQLKT TTTAAISRDF
     TEDRIWLNGR EEDMGHPRLQ ACLREIRRLA RKRRSDGHED PLPLSLSYKV HVASENNFPT
     AAGLASSAAG YACLAYTLAR VYGVDSDLSE VARRGSGSAC RSLYGGFVEW QMGERPDGKD
     SVACQVAPES HWPELRVLIL VVSAERKPMG STAGMQTSVE TSALLKFRAE ALVPPRMAEM
     TRCIRERNFQ AFGQLTMKDS NQFHATCLDT FPPISYLSDT SRRIIQLVHR FNAHHGQTKV
     AYTFDAGPNA VVFTLDDTVA EFVAAVRHSF PPESNGDKFL KGLPVEPVLL SDELKAVLGM
     DPVPGSIRYI IATQVGPGPQ VLDDPGAHLL GPDGLPKPAA
//